Welcome to DU! The truly grassroots left-of-center political community where regular people, not algorithms, drive the discussions and set the standards. Join the community: Create a free account Support DU (and get rid of ads!): Become a Star Member Latest Breaking News General Discussion The DU Lounge All Forums Issue Forums Culture Forums Alliance Forums Region Forums Support Forums Help & Search

malaise

(268,930 posts)
Sat Jun 7, 2014, 04:32 PM Jun 2014

Fasting triggers stem cell regeneration of damaged, old immune system

https://news.usc.edu/63669/fasting-triggers-stem-cell-regeneration-of-damaged-old-immune-system/
<snip>
In the first evidence of a natural intervention triggering stem cell-based regeneration of an organ or system, a study in the June 5 issue of the Cell Stem Cell shows that cycles of prolonged fasting not only protect against immune system damage — a major side effect of chemotherapy — but also induce immune system regeneration, shifting stem cells from a dormant state to a state of self-renewal.

In both mice and a Phase 1 human clinical trial, long periods of not eating significantly lowered white blood cell counts. In mice, fasting cycles then “flipped a regenerative switch,” changing the signaling pathways for hematopoietic stem cells, which are responsible for the generation of blood and immune systems, the research showed.

We could not predict that prolonged fasting would have such a remarkable effect in promoting stem cell-based regeneration of the hematopoietic system.

The study has major implications for healthier aging, in which immune system decline contributes to increased susceptibility to disease as people age. By outlining how prolonged fasting cycles — periods of no food for two to four days at a time over the course of six months — kill older and damaged immune cells and generate new ones, the research also has implications for chemotherapy tolerance and for those with a wide range of immune system deficiencies, including autoimmunity disorders.

---------------------
Very interesting
37 replies = new reply since forum marked as read
Highlight: NoneDon't highlight anything 5 newestHighlight 5 most recent replies
Fasting triggers stem cell regeneration of damaged, old immune system (Original Post) malaise Jun 2014 OP
That's one way I used to keep my alphabet soup of diseases under control Warpy Jun 2014 #1
I'm curious about Muslims now malaise Jun 2014 #8
Having spent some time in Mbrow Jun 2014 #13
Whle fasting, Dick Gregory used to use very pure water that he touched up with truedelphi Jun 2014 #35
Probably not, because they have breakfast before dawn and a big feast when the sun goes down Warpy Jun 2014 #14
Interesting indeed! KT2000 Jun 2014 #2
Thanks for posting. dipsydoodle Jun 2014 #3
Interesting! StarryNite Jun 2014 #4
I remember hearing something related to this a long time ago, it seems.. Voice for Peace Jun 2014 #5
The hungry mice lived longer but hated every extra minute of it. nt tblue37 Jun 2014 #6
Especially if they are "foodie" mice. ErikJ Jun 2014 #9
Actually, they didn't live longer. Jackpine Radical Jun 2014 #17
The interminable agony of waiting for the next morsel.. Voice for Peace Jun 2014 #23
that's right!!! Did you just make that up? Because as I recall, that was an actual factor. Voice for Peace Jun 2014 #21
As I said, they hated every extra minute of it. nt tblue37 Jun 2014 #33
Thom Hartmann was on a Fasting Diet ErikJ Jun 2014 #7
I'd love to know malaise Jun 2014 #12
You guys might like this Trajan Jun 2014 #32
Great news. And so many links to so many things of interest there. Thanks, malaise. freshwest Jun 2014 #10
Yes - it's a great web site malaise Jun 2014 #11
When I transitioned to mostly raw, vegan some years ago, I fasted twice a week. No hunger at all. freshwest Jun 2014 #28
We eat mostly fish, some chcken malaise Jun 2014 #31
Perhaps this is why when you get sick you often lose your appetite. n/t A Simple Game Jun 2014 #15
Excellent point malaise Jun 2014 #16
I makes sense, when you are sick that nature would take over and renew your immune system. n/t A Simple Game Jun 2014 #19
Some of us don't have much time left. Could they give some guidelines on the fasting? AAO Jun 2014 #18
you might check out this book NJCher Jun 2014 #22
thanks! AAO Jun 2014 #25
The last paragraph of the OP: morningfog Jun 2014 #24
Maybe once we understand this we can start group fasting malaise Jun 2014 #27
Or we could take turns sticking fingers down our throats! AAO Jun 2014 #29
, blkmusclmachine Jun 2014 #20
Kicked and recommended. Uncle Joe Jun 2014 #26
From the article - "undertaken only under the guidance of a physician" - pinto Jun 2014 #30
Thanks... blue sky at night Jun 2014 #34
Thanks for posting this, malaise. City Lights Jun 2014 #36
You're welcome malaise Jun 2014 #37

Warpy

(111,245 posts)
1. That's one way I used to keep my alphabet soup of diseases under control
Sat Jun 7, 2014, 04:43 PM
Jun 2014

during my decades of being disqualified from health insurance. I had read about the effect of fasting in a study in the 1940s and was surprised that it would knock a flare off in a few days.

At least a study now shows how it worked. They didn't have a clue in the 40s.

malaise

(268,930 posts)
8. I'm curious about Muslims now
Sat Jun 7, 2014, 06:41 PM
Jun 2014

since they have serious fasting during Ramadan. I wonder if studies have been done on the medical benefits.

Mbrow

(1,090 posts)
13. Having spent some time in
Sat Jun 7, 2014, 06:55 PM
Jun 2014

Various Muslim countries, I believe the fasting is only during the day, from sunrise to sun set. I'm sure one of our Muslim readers can correct me if I'm wrong about that. I wonder if this type of fasting works as well? I've been trying to fast at least twice a week. It helps with the weight control.

truedelphi

(32,324 posts)
35. Whle fasting, Dick Gregory used to use very pure water that he touched up with
Sun Jun 8, 2014, 12:57 PM
Jun 2014

Lemon.

I have found that the better and purer the water, the easier it is to keep my appetite under control.

Warpy

(111,245 posts)
14. Probably not, because they have breakfast before dawn and a big feast when the sun goes down
Sat Jun 7, 2014, 06:58 PM
Jun 2014

The fast has to be a couple of days for it to work.

The last one I did was a two day fast around a bowel prep and colonoscopy, it was just easier not to eat anything and just swig some homemade lemon soda until it was time to down the half gallon of loaded Gatorade. I have to admit I felt quite a bit better for the next couple of weeks.

 

Voice for Peace

(13,141 posts)
5. I remember hearing something related to this a long time ago, it seems..
Sat Jun 7, 2014, 06:03 PM
Jun 2014

that mice who were kept always just barely on the
edge of starvation actually ended up living longer
and being more healthy overall than the mice who
ate their fill.

 

Voice for Peace

(13,141 posts)
23. The interminable agony of waiting for the next morsel..
Sat Jun 7, 2014, 07:31 PM
Jun 2014

but in fact, as I have been reminded, they did live
longer but were very cranky.

 

Voice for Peace

(13,141 posts)
21. that's right!!! Did you just make that up? Because as I recall, that was an actual factor.
Sat Jun 7, 2014, 07:30 PM
Jun 2014

They lived longer, but were extremely cranky.

 

Trajan

(19,089 posts)
32. You guys might like this
Sat Jun 7, 2014, 08:20 PM
Jun 2014
http://vimeo.com/m/54089463

I've been doing ADF (Alternate Day Fasting) for about a year now ... I lost approx 55 pounds ...

The clip may or may not work ...

freshwest

(53,661 posts)
28. When I transitioned to mostly raw, vegan some years ago, I fasted twice a week. No hunger at all.
Sat Jun 7, 2014, 07:53 PM
Jun 2014

It took me two years to get there and I never felt better. Yes, I know that's radical, but then just plain vegetarian or lacto vegetarians is radical to some, I don't judge anyone. Eating is more than sustenance.

But a series of events got me to what for me is the S.A.D. (standard american diet) and it's been downhill ever since. Sadly, I had no real life support for it and a lot going against it, and I felt like an outlaw, LOL.

Another link there discussed excess animal proteins and immune issues, and while my vegan routine had drawbacks, they were exceeded by the benefits. I am using a lot of dairy and it doesn't agree with me. I don't preach to anyone, everyone is different, everyone is somone else's cra-cra.

But that piece has inspired me to return to whatever is as close to where I was a few years ago.

Also saw articles about the work of Fulbright scholars. Yes, the demise of the program has been greatly exaggerated, they haven't even lost funding, just shifted to different directions.

There were senior housing solutions and many other things, even an analysis of the ACA and Canadian systems:

Obamacare explained by USC Price professor

“One thing Canadians think distinguishes them in a favorable manner from the U.S. is that they can offer everybody what they think is an inalienable right,” Greenwald said of health insurance. “It’s a very big cultural distinction for them between the two countries.

The focus of his speeches was to set up two possible outcomes for health care in the United States following the implementation of the ACA. One possibility is that reform will lead to the sustainability of the current private sector system by ensuring access, improving the quality of care and controlling costs or the expansion of coverage will lead to a system so expensive that it will be necessary to change to a model more like Canada where it’s entirely publicly funded.

“This is either the end of the beginning or the beginning of the end,” Greenwald said. “We’ve started on a sustainable path or we’ve crossed the Rubicon to where expanding coverage and increasing expenditures will lead to major reforms that depart from the current system.”


http://news.usc.edu/62111/obamacare-as-explained-by-usc-price-professor/

Thanks again for the inspiration.

NJCher

(35,654 posts)
22. you might check out this book
Sat Jun 7, 2014, 07:30 PM
Jun 2014
The 5:2 Diet by Kate Harrison. The principle of the diet is to fast two days and eat what you want for the other five.

She explains a lot about fasting when she discusses the two fasting days.


Cher
 

morningfog

(18,115 posts)
24. The last paragraph of the OP:
Sat Jun 7, 2014, 07:37 PM
Jun 2014

"[P]eriods of no food for two to four days at a time over the course of six months -- kill older and damaged immune cells and generate new ones, the research also has implications for chemotherapy tolerance and for those with a wide range of immune system deficiencies, including autoimmunity disorders."

pinto

(106,886 posts)
30. From the article - "undertaken only under the guidance of a physician" -
Sat Jun 7, 2014, 08:00 PM
Jun 2014

“More clinical studies are needed, and any such dietary intervention should be undertaken only under the guidance of a physician.”

blue sky at night

(3,242 posts)
34. Thanks...
Sun Jun 8, 2014, 12:45 AM
Jun 2014

I have been fasting one day a week for a couple of years now....need to extend it out a few more days I guess.

Latest Discussions»General Discussion»Fasting triggers stem cel...