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madokie

(51,076 posts)
Mon Jun 9, 2014, 04:26 AM Jun 2014

One of Big Pharma's Most Disastrous Drugs Destroyed This Man's Spine

Merck was aware of a popular drug's impact on bones but still pushed it on doctors and patients.


It has been a decade since Merck's "super-aspirin" Vioxx was withdrawn from the market after a study showed it doubled the risk of heart attacks and strokes. Heavily advertised by celebrity athletes like Dorothy Hamill and Bruce Jenner and used by approximately 20 million patients, estimates of the heart attacks caused by Vioxx range from 27,000 to up to 140,000. The Vioxx scandal made Merck the poster child for deceptive marketing because the cardiovascular risk data was deliberately withheld from the FDA, medical journals and the drug-taking public and their doctors, according to news reports. In 2010, Merck compensated 20,591 heart attack and 12,447 stroke plaintiffs out of a $4.85 billion settlement fund.

Now, in an improbable chain of events, Merck is returning to court against its will to face charges that Vioxx also caused devastating non-healing of spine/bone after surgical procedures, a charge supported by scientific studies. The suit is brought by Dennis Harrison, one of few plaintiffs remaining from the 70,000-case multidistrict litigation (MDL) that led to Merck's 2007 settlement. Unlike patients prescribed Vioxx for its FDA-approved uses of osteoarthritis, menstrual pain and acute pain, Harrison was prescribed Vioxx for the unapproved use of rheumatoid arthritis (RA). In 2011, Merck also settled charges that it "misbranded" Vioxx by promoting it for RA, illegal marketing that made RA the fifth most common reason for Vioxx use.

Because RA was an unapproved Vioxx use and Merck is not shielded by FDA approval, the suit claims outright fraud. "It is no different than if Merck sold the drug on a street corner," Jim Duggan, who has been providing legal support to Harrison, told me in a phone interview. A summary judgment filed by Merck (a legal move that says the case is without merit and does not need to be tried) was denied in May and Merck must go to court in New York.

Harrison, 61, a former product planner and business strategist with ATT/Lucent Technologies, sustained permanent spinal damage from years of high doses of Vioxx, according to court filings, when his body failed to form bone after a 2001 spinal fusion operation. He spent months in a nursing home unable to walk, endured sepsis and other life-threatening conditions and is largely bedridden to this day. Nearly all of his doctors attended Merck-funded seminars to build confidence in Vioxx, claims Harrison, and were not told about its serious bone effects. "Merck knew and the doctors and public didn't," says Harrison.


http://www.alternet.org/personal-health/one-big-pharmas-most-disastrous-drugs-destroyed-mans-spine
16 replies = new reply since forum marked as read
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One of Big Pharma's Most Disastrous Drugs Destroyed This Man's Spine (Original Post) madokie Jun 2014 OP
Merck illegally marketed VIOXX for an unapproved use. Sounds like more WOO to me. pnwmom Jun 2014 #1
Vioxx isn't woo sakabatou Jun 2014 #2
VIOXX prescribed for RA was woo -- no approved scientific studies supported it. n/t pnwmom Jun 2014 #10
They don't know the difference MattBaggins Jun 2014 #12
Nailed it Jesus Malverde Jun 2014 #4
If the charges are true, then it's fraud Orrex Jun 2014 #8
Woo-ness, or the lack thereof, is determined by whether or not pnwmom Jun 2014 #11
That's one way. Orrex Jun 2014 #13
I don't support woo any more than you do. I just disagree on what constitutes woo. nt pnwmom Jun 2014 #14
In that case... Orrex Jun 2014 #15
Actually Merck used to be a outstanding drug manufacture classykaren Jun 2014 #3
Don't worry, this is just "woo"... sendero Jun 2014 #5
The drug was recalled BainsBane Jun 2014 #6
The surprising thing here...... DeSwiss Jun 2014 #7
20x more people killed by Vioxx than by 9/11 MannyGoldstein Jun 2014 #9
Another victim of the War on Drugs. hunter Jun 2014 #16

pnwmom

(108,976 posts)
1. Merck illegally marketed VIOXX for an unapproved use. Sounds like more WOO to me.
Mon Jun 9, 2014, 04:36 AM
Jun 2014

There weren't any approved studies showing that this drug was safe and effective for RA sufferers, yet Merck marketed it to their doctors anyway.


Orrex

(63,203 posts)
8. If the charges are true, then it's fraud
Mon Jun 9, 2014, 06:29 AM
Jun 2014

Last edited Mon Jun 9, 2014, 08:51 AM - Edit history (1)

"Woo-ness" isn't determined by whether or not a treatment works; it's determined by whether or not the advocates & users of a product/procedure claim that it works according to magical or psedoscientific means.

If Merck engaged in fraud, it should certainly face criminal penalties. If a proponent of woo engages in fraud, then that proponent should certainly face criminal penalties as well.

Why do you believe that this case is woo, other than because it bolsters your faith in pseudoscience and your distrust/misunderstanding of actual science and medicine?

pnwmom

(108,976 posts)
11. Woo-ness, or the lack thereof, is determined by whether or not
Mon Jun 9, 2014, 12:12 PM
Jun 2014

the treatment has been proven with repeated scientific studies to work.

There were no approved scientific studies on the use of VIOXX for RA patients. Its use was as much "woo" as any unproven treatment.

Orrex

(63,203 posts)
13. That's one way.
Mon Jun 9, 2014, 12:27 PM
Jun 2014

If an assertion is consistent with and does not contradict established science but is ultimately shown to be incorrect, then the asserton can be wrong and it can be fraudulent, but it need not be woo.

I don't know why you're arguing this point, either, because even if we accept your notion, you're simply linking woo-in-general to the criminally bad of a particular company. Why would you seek such an alliance?


Incidentally, were the negative side effect of Vioxx identified through science or through woo? Can you point to even one instance when pseudoscience was used to show that some other kind of pseudoscience was shown to be fraudulent?

Orrex

(63,203 posts)
15. In that case...
Mon Jun 9, 2014, 12:40 PM
Jun 2014

I would be interested to read your complaints about such pseudoscience as the "supplement" industry or "therapeutic touch" and similar forms of "energy" healing.

That is, I don't recall ever seeing you come out against any of those forms of woo; instead, you focus your attention on the occasional bad practice of actual science or actual medicine.

Your consistency in this regard suggests, even if you're not a woo supporter, you are curiously specific in selecting your targets.

classykaren

(769 posts)
3. Actually Merck used to be a outstanding drug manufacture
Mon Jun 9, 2014, 05:39 AM
Jun 2014

Remember before Ronald Regan, when the FDA did it's own drug testing and did not depend on data from the drug manufacturers ?

sendero

(28,552 posts)
5. Don't worry, this is just "woo"...
Mon Jun 9, 2014, 05:43 AM
Jun 2014

... "medical science" said this drug was safe. Nothing to see here.

BainsBane

(53,031 posts)
6. The drug was recalled
Mon Jun 9, 2014, 05:46 AM
Jun 2014

Obviously it wasn't safe, but the reason for the recall was that it contributed to heart problems.

hunter

(38,310 posts)
16. Another victim of the War on Drugs.
Mon Jun 9, 2014, 12:44 PM
Jun 2014

Opiates, cannabis, any other number of drugs would have been less dangerous.

But OH NO! Effective drugs with less dangerous side effects are EVIL!

The perfect Pharmaceutical company pain killer would kill the pain but it would never let you forget you were still broken person, maybe it would put a big scarlet D for "druggie" on your face because that's some vengeful puritanical god's plan or something.

Our society is sick, and there are too many profiting from this sickness. Corporations (Merck) and institutions (the DEA) will lie, cheat, and steal to keep those drug profits flowing.


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