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(4,429 posts)Some of my cliff notes (feel free to correct me!)
1. Vaccines
Phase III study starts in July
This will be Moderna with 30,000 participants
a big clinical trial with lots of data point
also AstraZeneca trial will start (perhaps even simultaneous)
Two more starting soon afterwards (so as many four or 5 vaccine trials
in the next few months
In phase III they need to see some disease (even control group)
to show the vaccine is protective
Therefore, it could take months and months
It depends on whether there is an outbreak (opportunity for exposure)
Trial will include mostly those in 18-55 age group
But some will be older (even elderly)
And some with co-morbidities
He's cautiously optimistic
Why??
because so many of us make a good immunological response generally to the covid-19
thus we know body is capable of clearing the infection (which is good proof of concept)
He's more concerned with durability of response
often corona virus durability (like with common cold) is only a year
2. Will there be enough supply of vaccine?
The companies are manufacturing these AT RISK. So, by end of year they will have ramped up production to have 100 million doses (and even more in January of next year)
this is at same time as vaccine is developed (so at financial risk)
3. Role of monoclonal antibodies and convalescent plasma
He sees a role as prophylaxis or treatment
Looking to use it for those at risk.
In NY about 1 million are able to donate (possibility)
4. Vitamin D
If you are deficient: you might have a poorer outcome with Covid-19
However, most people in developed world are NOT deficient
(Also, those deficient of Vitamin A might have increased risks with covid
but again - most aren't deficient)
5. Is the Zinc and azithromycin combination helpful
Fauci: not enough data. Anecdotal stuff all over the place
But no RCT's.
6. How protests will impact pandemic
First, some states leapfrogged over our gate marks
No masks, close contact
Now big protests
We won't know for a few weeks
7. Schools
Diverse country means different responses
In some parts of country it will be easy
Other parts, modified versions. Outdoor, half-days, less crowding
All depends on where you are
8. Asymptomatic People
Percentage is probably close to 25-50%
Some are antibody negative
Others are robust
Very interesting. Very varied
Maybe reason in common cold durability of protection ranges
from 3-6 months to always less than a year (this has implications for a
vaccine).
It might be different in the covid-19. But if it acts like other corona viruses, it might
not be durable.
Frustratedlady
(16,254 posts)pazzyanne
(6,547 posts)provides a piece of data for future use. Thank you!