Questions raised over hydroxychloroquine study which caused WHO to halt trials for Covid-19

Exclusive: Australian researchers query origin of data used for Lancet study, but stress there is no evidence drug is a safe or effective treatment

Melissa Davey
@MelissaLDavey
Wed 27 May 2020 22.27 EDTLast modified on Thu 28 May 2020 02.05 EDT

Questions have been raised by Australian infectious disease researchers about a study published in the Lancet which prompted the World Health Organization to halt global trials of the drug hydroxychloroquine to treat Covid-19.

The study published on Friday found Covid-19 patients who received the malaria drug were dying at higher rates and experiencing more heart-related complications than other virus patients. The large observational study analysed data from nearly 15,000 patients with Covid-19 who received the drug alone or in combination with antibiotics, comparing this data with 81,000 controls who did not receive the drug.

The findings prompted researchers from around the world to reassess their own clinical trials of the drug for preventing and treating Covid-19. The World Health Organization halted all its trials involving hydroxychloroquine due to the concerns raised in the study about its efficacy and safety. It was once viewed as among the most promising medicines to treat the virus, though no study to date has found this to be the case, and the drug can have toxic side-effects. The Australian Department of Health had been stockpiling millions of doses of the drug in case clinical trials found it proved useful.

The study, led by the Brigham and Women’s Hospital Center for Advanced Heart Disease in Boston, examined patients in hospitals around the world, including in Australia. It said researchers gained access to data from five hospitals recording 600 Australian Covid-19 patients and 73 Australian deaths as of 21 April.

More:
https://www.theguardian.com/science/2020/may/28/questions-raised-over-hydroxychloroquine-study-which-caused-who-to-halt-trials-for-covid-19