The truth about depression. [View All]

What some people who sell the "other" stuff, that is now causing Lilly great concern... may not want you to know. To know is good, to be kept in the dark about the role of DHA and other essential fats in autoimmune disease, how well the cellular sodium pump works, depression, schizophrenia is to be a pawn of corporate America, a rube, a mark, a lab rat.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15172679
1: Prostaglandins Leukot Essent Fatty Acids. 2004 Jul;71(1):13-8. Related Articles, Links
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In humans, the seasonal variation in poly-unsaturated fatty acids is related to the seasonal variation in violent suicide and serotonergic markers of violent suicide.

De Vriese SR, Christophe AB, Maes M.
Department of Internal Medicine, Division of Nutrition, Ghent University Hospital, Belgium.
BACKGROUND: Depression is accompanied by a depletion of n-3 poly-unsaturated fatty acids (PUFAs). There is also a negative correlation between suicide and fish-oil intake (rich in n-3 PUFAs) across different countries. Both depression and suicide show a seasonal variation and are related to disorders in the serotonergic system. AIMS: The present study was carried out to determine if there is a seasonal variation in the PUFA fractions in serum phospholipids and whether there are significant relationships between lowered n-3 PUFA status and the seasonal variation in the number of suicide deaths and serotonergic markers of suicide. METHODS: We took monthly blood samples during 1 calendar year from 23 healthy volunteers and analyzed the PUFA composition in serum phospholipids and related those data to the annual variation in the mean weekly number of suicides for Belgium and the Bmax <3H>-paroxetine binding to platelets in the same 23 subjects. RESULTS: Significant annual rhythms were detected in the long-chain PUFAs only, i.e. arachidonic acid (C20: 4n-6; AA), eicosapentaenoic acid (C20: 5n-3; EPA), and docosahexaenoic acid (C22: 6n-3; DHA). There was a significant correlation between the changes over the last 2 weeks in AA and EPA and the mean weekly number of violent, but not nonviolent, suicide deaths in Belgium. There was a significant correlation between the PUFAs, AA and DHA, and the Bmax <3H>-paroxetine binding to platelets. CONCLUSIONS: Our results show that there is a true seasonality in long-chain PUFAs, such as AA, EPA and DHA. The results suggest that the seasonality in PUFAs may be related to the incidence of violent suicide and the expression of the serotonin transporter complex. Copyright 2004 Elsevier Ltd.

PMID: 15172679

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15279495
1: Naliwaiko K, Araujo RL, da Fonseca RV, Castilho JC, Andreatini R, Bellissimo MI, Oliveira BH, Martins EF, Curi R, Fernandes LC, Ferraz AC. Related Articles, Links
Abstract Effects of fish oil on the central nervous system: a new potential antidepressant?
Nutr Neurosci. 2004 Apr;7(2):91-9.
PMID: 15279495

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5: Frasure-Smith N, Lesperance F, Julien P. Related Articles, Links
Abstract Major depression is associated with lower omega-3 fatty acid levels in patients with recent acute coronary syndromes.
Biol Psychiatry. 2004 May 1;55(9):891-6.
PMID: 15110732

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15023646
8: Makrides M, Crowther CA, Gibson RA, Gibson RS, Skeaff CM. Related Articles, Links
Abstract Docosahexaenoic acid and post-partum depression - is there a link?
Asia Pac J Clin Nutr. 2003;12 Suppl:S37.
PMID: 15023646

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14610651
Turner N, Else PL, Hulbert AJ. Related Articles, Links
Abstract Docosahexaenoic acid (DHA) content of membranes determines molecular activity of the sodium pump: implications for disease states and metabolism.
Naturwissenschaften. 2003 Nov;90(11):521-3. Epub 2003 Oct 10.
PMID: 14610651

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12640327
12: Colin A, Reggers J, Castronovo V, Ansseau M. Related Articles, Links
Abstract
Encephale. 2003 Jan-Feb;29(1):49-58. Review. French.
PMID: 12640327

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12480795
13: Simopoulos AP. Related Articles, Links
Free Full Text Omega-3 fatty acids in inflammation and autoimmune diseases.
J Am Coll Nutr. 2002 Dec;21(6):495-505. Review.
PMID: 12480795

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15: Hibbeln JR. Related Articles, Links
Abstract Seafood consumption, the DHA content of mothers' milk and prevalence rates of postpartum depression: a cross-national, ecological analysis.
J Affect Disord. 2002 May;69(1-3):15-29.
PMID: 12103448