Help Wanted: Human Guinea Pigs (The Internationalist, via AlterNet)

Help Wanted: Human Guinea Pigs

By Betsy Model, The Internationalist. Posted May 9, 2007.




If you've ever wondered why we so rarely hear of drug trials going awry in the United States, Sonia Shah, author of The Body Hunters: Testing New Drugs on the World's Poorest Patients (The New Press, 2006), has the unattractive answer: we "offshore" the drug trials to developing nations and to those who simply can't afford to say "anywhere but here."

Betsy Model: You've said that multi-national pharmaceutical companies are exporting their clinical trials to countries like Asia and Africa not just for cost savings and the ultimate profitability of the new drug, but because ethical oversight is minimal and it's easier to find large quantities of willing test participants. Why is that?

Sonia Shah: Recruiting subjects for drug trials has become the number one bottleneck in drug development in Western countries. The more proven drugs we have available to us, it seems, the less willing we are to play test subject for experimental ones. In countries where sick, untreated patients are abundant, the opposite is true. So recruitment into trials is rapid, and drug companies save money and beat their rivals to market. It's good business.

Are you suggesting that there is a "something is better than nothing" mentality when it comes to testing potentially harmful or fatal drugs or drug regimens on the poor in third world countries?

Yes. Many people in the clinical trials industry argue that "Look, these people are not getting any care at all. At least we're experimenting there so that some of them can get something. It's better than nothing. It's not like people in Malawi are developing their own pharmaceutical industry...they still need the predominantly Western, multi-national drug industry to make medicines for them. They're lucky they're getting this little crumb we're giving them."

So, the rationalization or reading on the practice is that "everyone benefits?"

That's definitely a common argument within the clinical trials world. It's a self-interested misreading because nobody can guarantee that an individual subject will benefit in an experimental trial. There's uncertainty there -- that's why it's an experiment.

If you send a crappy job somewhere in a third world country, even if it's a terrible job and the pay is only a dollar a day, you know in the normal course of things that anyone who goes to work there is going to make their dollar each day. They're going to get that benefit, however slim it is. That's not true in a clinical trial. You can say that overall, only 5 percent of patients are going to have XYZ side-effects but for that one individual person you can't say for sure that they will benefit. They're not going to get that equivalent of one dollar a day. They might get nothing, they might get injured for life. They might be part of a control group and only get placebos. .....(more)

The complete piece is at: http://www.alternet.org/rights/51425/