Prayers/good vibes thread for the Big Dog...

To wish him the best in a tough spot, and to counter the negative and destructive things said about him by the right-wing media and freepers at large.

Hang in there, Big Dog -- here's to smooth sailing with the surgery, and to a speedy and full recovery.

We need you, sir!!! :thumbsup:

Miss you BAD big dog!

:thumbsup: Hope you feel better real soon Big DOg!

:grouphug: :scared: :thumbsup:

:kick:

and may he get well quickly... and may he learn how to reverse the symptoms that his body is presenting to him.

MOD... these papers are in the public domain at the NIH.. they are not copyrighted.

1: J Assoc Physicians India. 1998 Mar;46(3):299-306. Related Articles, Links


Coenzyme Q in cardiovascular disease.

Singh RB, Niaz MA, Rastogi V, Rastogi SS.

Heart Research Laboratory, Medical Hospital and Research Centre, Moradabad, India.

Coenzyme Q10 or ubiquinone normally present in many plant and animal cells is an antioxidant. Coenzyme Q10 deficiency has been observed in patients with congestive heart failure, angina pectoris, coronary artery disease, cardiomyopathy, hypertension, mitral valve prolapse and after coronary revascularization. Coenzyme Q10 is involved in the synthesis of ATP and hence is useful in preventing cellular damage during ischaemia-reperfusion injury. The clinical benefits are mainly due to its ability to improve energy production, antioxidant activity, and membrane stabilizing properties. Several studies showed that coenzyme Q could be useful in patients with congestive heart failure, angina pectoris, cardiomyopathy, coronary artery disease and in the preservation of myocardium. Coenzyme Q10 is normally present in the low density lipoprotein cholesterol fraction and inhibits its oxidation. It can also regenerate vitamin E. Coenzyme Q10 is known for producing minor gastrointestinal discomfort and elevation in SGOT and LDH when used.

Publication Types:
Review
Review, Academic

PMID: 11273351

1: Int J Cardiol. 1999 Jan;68(1):23-9. Related Articles, Links


Serum concentration of lipoprotein(a) decreases on treatment with hydrosoluble coenzyme Q10 in patients with coronary artery disease: discovery of a new role.

Singh RB, Niaz MA.

Centre of Nutrition, Medical Hospital and Research Centre, Moradabad, India.

OBJECTIVE: To examine the effect of coenzyme Q10 supplementation on serum lipoprotein(a) in patients with acute coronary disease. STUDY DESIGN: Randomized double blind placebo controlled trial. SUBJECTS AND METHODS: Subjects with clinical diagnosis of acute myocardial infarction, unstable angina, angina pectoris (based on WHO criteria) with moderately raised lipoprotein(a) were randomized to either coenzyme Q10 as Q-Gel (60 mg twice daily) (coenzyme Q10 group, n=25) or placebo (placebo group, n=22) for a period of 28 days. RESULTS: Serum lipoprotein(a) showed significant reduction in the coenzyme Q10 group compared with the placebo group (31.0% vs 8.2% P<0.001) with a net reduction of 22.6% attributed to coenzyme Q10. HDL cholesterol showed a significant increase in the intervention group without affecting total cholesterol, LDL cholesterol, and blood glucose showed a significant reduction in the coenzyme Q10 group. Coenzyme Q10 supplementation was also associated with significant reductions in thiobarbituric acid reactive substances, malon/dialdehyde and diene conjugates, indicating an overall decrease in oxidative stress. CONCLUSION: Supplementation with hydrosoluble coenzyme Q10 (Q-Gel) decreases lipoprotein(a) concentration in patients with acute coronary disease.

Publication Types:
Clinical Trial
Randomized Controlled Trial

PMID: 10077397

Role of coenzyme Q10 in chronic heart failure, angina, and hypertension.

Tran MT, Mitchell TM, Kennedy DT, Giles JT.

School of Pharmacy, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA.

PURPOSE: Coenzyme Q10 (CoQ10) has a pathophysiologic role in many disease states. The purpose of this review is to provide recommendations regarding the safety, efficacy, and dosing of CoQ10 in the management of chronic heart failure (CHF), angina, and hypertension. DATA SOURCES: Literature pertaining to the safety and efficacy of CoQ10 specifically in cardiovascular indications was reviewed. We used relevant clinical trials, articles, reviews, and letters that were selected from a literature search of the MEDLINE database (1974-2000), Micromedex Healthcare Series, and the Natural Medicines Comprehensive Database. FINDINGS: Coenzyme Q10 administered orally has favorable actions in the described cardiovascular conditions and appears to be safe and well tolerated in the adult population. Issues concerning optimum target dosages, potential interactions, monitoring parameters, and the role of CoQ10 as a monotherapeutic agent need to be investigated further. Favorable effects of CoQ10 on ejection fraction, exercise tolerance, cardiac output, and stroke volume are demonstrated in the literature; thus, the use of CoQ10 as adjuvant therapy in patients with CHF may be supported. CONCLUSIONS: Coenzyme Q10 therapy in angina and hypertension cannot be substantiated until additional clinical trials demonstrate consistent beneficial effects. However, CoQ10 may be recommended as adjuvant therapy in selected patients with CHE At this time, CoQ10 should not be recommended as monotherapy or first-line therapy in any disease state.

Publication Types:
Review
Review, Tutorial

PMID: 11444576

1: Cardiovasc Drugs Ther. 1998 Sep;12(4):347-53. Related Articles, Links


Randomized, double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction.

Singh RB, Wander GS, Rastogi A, Shukla PK, Mittal A, Sharma JP, Mehrotra SK, Kapoor R, Chopra RK.

Heart Research Laboratory, Centre of Nutrition Medical Hospital and Research Centre, Moradabad, India.

The effects of oral treatment with coenzyme Q10 (120 mg/d) were compared for 28 days in 73 (intervention group A) and 71 (placebo group B) patients with acute myocardial infarction (AMI). After treatment, angina pectoris (9.5 vs. 28.1), total arrhythmias (9.5% vs. 25.3%), and poor left ventricular function (8.2% vs. 22.5%) were significantly (P < 0.05) reduced in the coenzyme Q group than placebo group. Total cardiac events, including cardiac deaths and nonfatal infarction, were also significantly reduced in the coenzyme Q10 group compared with the placebo group (15.0% vs. 30.9%, P < 0.02). The extent of cardiac disease, elevation in cardiac enzymes, and oxidative stress at entry to the study were comparable between the two groups. Lipid peroxides, diene conjugates, and malondialdehyde, which are indicators of oxidative stress, showed a greater reduction in the treatment group than in the placebo group. The antioxidants vitamin A, E, and C and beta-carotene, which were lower initially after AMI, increased more in the coenzyme Q10 group than in the placebo group. These findings suggest that coenzyme Q10 can provide rapid protective effects in patients with AMI if administered within 3 days of the onset of symptoms. More studies in a larger number of patients and long-term follow-up are needed to confirm our results.

Publication Types:
Clinical Trial
Randomized Controlled Trial

PMID: 9825179

I (almost) always have had nothing but the greatest respect for Mr. Clinton. I miss having someone in the white house that is tough and capable, not because he can shoot his mouth off, but because he knows what he is doing. Sure the man made some mistakes, but most of his 2 terms were very very positive times for America. But I gained the most respect for Mr. Clinton after his term. Sept. 11, 2001 he was out on the streets of NYC comforting people, hugging them, consoling them, LISTENING to them, while this wretched excuse of a pResident was flying around on a plane like the chickenshit he is. For ourselves, we have to hold out hope that Mr. Clinton will pull through this trying time.

Can I also suggest we keep Sen. Clinton in our thoughts and hearts? This cannot be an easy time for her either.

Hopefully, he'll be able to get out there for Kerry before long, but his health is the most important thing.

and the speedier the better. Gonna have to get that diet straight now, Bill. Hold back on the cheeseburgers-you're not 18 anymore.