* Locked-In syndrome, a type of paralysis.
* Library Information System
* the IATA airport code for Portela Airport, Lisbon, Portugal
* Library and Information Science
* Laboratory information system, databases oriented towards medical laboratories.
* Land Information System
* Log Interchange Standard, is a digital well log format designed by Schlumberger in 1972 primarily for use with 9-track 1/2 inch magnetic tape. It has been phased out.
* Language-independent specification, a programming language specification providing a common interface usable for defining semantics applicable to arbitrary programming language bindings
* Laser Isotope Separation, a means of producing enriched uranium from uranium ore
* League and Self-Defense, a Polish political party
* Life Insurance Settlement, a financial product for people with unwanted life insurance policies
* Lis Coat of Arms, a Polish coat of arms
* Location Information Server, a server that provides location information, either in the form of geographic location or a street address
* Local Install Source, a Microsoft Windows setup feature that copies installation source files into a hidden folder
* Low Income Subsidy (Medicare)
* Luxembourg Income Study (LIS), a cross-national database of income survey micro-data
* Luanda International School, a primary and high school in Luanda, Angola
* Lucaya International School, located on Grand Bahama Island, Bahamas.
* Line Information System, a method of information sharing for machines in a plant or factory, similar to a Local Area Network
* Lingua Italiana dei Segni, i.e. Italian Sign Language, used by Italian deaf people
* Logical IP Subnets.
* LIS programming language
* Lymphocytic interstitial pneumonia
* Lis, Illinois
http://en.wikipedia.org/wiki/LIS