Neuroscientists Map a New Target to Wipe Pain Away

ScienceDaily (June 5, 2011) — Researchers at the Indiana University School of Medicine have discovered a peptide that short circuits a pathway for chronic pain. Unlike current treatments this peptide does not exhibit deleterious side effects such as reduced motor coordination, memory loss, or depression, according to an article in Nature Medicine posted online June 5, 2011.

The peptide, CBD3, has been shown in mice to interfere with signals that navigate calcium channels to produce pain. Unlike other substances that block pain signals, CBD3 does not directly inhibit the influx of calcium. This is important as influx of calcium regulates heart rhythm and vital functions in other organs.

Rajesh Khanna, Ph.D., assistant professor of pharmacology and toxicology at the Indiana University School of Medicine, said the peptide discovered by him and his colleagues is potentially safer to use than addictive opioids or cone snail toxin Prialt® -- a recognized analgesic that is injected into the spinal column, both of which can cause respiratory distress, cardiac irregularities and other problems.

"After opioids-the gold standard for pain control -- the next target is calcium channels," said Dr. Khanna. "Along the pain pathway in the spinal cord, there are pain-sensing neurons called nociceptors that have an abundance of calcium channels."

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http://www.sciencedaily.com/releases/2011/06/110605132425.htm

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So many people are struggling with debilitating addictions.

I have so many patients with chronic pain who have developed such awful tolerances to opiods...they don't even help the patients anymore,but they can't stop taking them. it is SO sad.

I have chronic back pain, every time I ask for something that actually works, the doctor freaks out as if I am a demon from hell that will kill him in a dark alley. Careful how you look at people. I am looking for an alternative to doctors now. Why do I have to live a life of pain because doctors refuse to give out what works? I haven't been to bed in 2 years because if I sleep flat, I will take all day for my spine to stop hurting. I have noticed the neurosurgeons of Kansas City are not successful at resolving anything (I speak from experience.) I want my freedom back. I want to treat myself. Why do I have to pay off a doctor, pharma company, and pharmacist just for the things I need to live my life? Is that not slavery? I know it is. Those crosses at arlington are but darwin awards because America is not free. I know what would fix america too. Abolish the controlled substances act. That alone would save this country I guarantee it. (no more crime, no more health care crisis no more ivy league mafia enslavement of the masses) Yes I want also to be able to go to whoever I want for services. I mean I know a Veterinarian would do better for me than a doctor. My dog gets fixed the same day. But when I go in, it's a bunch of b.s. they would never actually fix anyone. That's not good for business. Dentists do it every time. They mess up other teeth so you can come in there every week and give them all of your extra money. They will keep on and on too. Ivy league mafia. perhaps unwitting, but still organized and still crime. Their gang gear insignia are white coats and ball pens / insurance forms. Doctors don't actually care for people. they will golf while you DIE if you don't have insurance. How could I ever be a doctor I couldn't..