Alzheimer's disease, ClinicalTrials.Gov, check it out.

What I am telling you is this. They are not doing this because they have not seen anecdotal evidence to support the idea that this approach has merit. What I am telling you is that these materials are safe and non-toxic. I am saying, help your friends/relatives in any way you can, some may not have the time to wait until this study goes through three phases.... 4Mor

http://clinicaltrials.gov/ct/gui/show/NCT00117403?order=5
Condition Intervention Phase
Alzheimer's Disease
Drug: Vitamin E
Drug: Vitamin C
Drug: Alpha-lipoic acid
Drug: Coenzyme Q

Study Type: Interventional
Study Design: Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Safety/Efficacy Study

Official Title: Evaluation of the Safety, Tolerability and Impact on Biomarkers of Anti-Oxidant Treatment of Mild to Moderate Alzheimer's Disease

Further Study Details:
Primary Outcomes: effect on cerebrospinal fluid (CSF) biomarkers related to oxidative damage
Secondary Outcomes: change in plasma and CSF concentrations of a-beta42 and a-beta40
Expected Total Enrollment: 75

Oxidative damage has been shown to be a factor in Alzheimer's disease (AD), and some studies have suggested that supplemental anti-oxidants can decrease the risk of AD or slow its progression. There are many candidate antioxidants, including combinations, which could be neuroprotective in established AD or could have efficacy in the prevention of AD. However, testing each of the possibilities in standard clinical trials is prohibitively expensive. This study will examine antioxidant supplements or vitamins which target specific cellular compartments, and look for evidence of biologically relevant effects in AD by measurement of biomarkers in CSF.

Two general cellular compartments where antioxidant supplements may act are the cytosol and mitochondria. The study will examine a combination of antioxidants that act primarily at cytosolic sites (vitamin E + C + α-lipoic acid) and a single mitochondrial antioxidant, coenzyme Q10.

This multicenter trial will recruit 75 participants who will be randomized into three groups:

25 participants will be given a combination of vitamin E 800 IU, vitamin C 200 mg, and alpha-lipoic acid 600 mg compounded as a single capsule, once per day, plus two placebo wafers three times per day with meals;
25 participants will be given CoQ 400 mg, compounded as a wafer, two wafers three times per day with meals, plus one placebo capsule per day;
25 participants will be given both the placebo wafers, two wafers three times per day with meals, plus one placebo capsule per day.
The treatment period will last four months. The effects of the two anti-oxidant treatments will be evaluated by measuring biomarkers in blood and cerebrospinal fluid (CSF) at the beginning and end of the 4-month period.

. . . is tumeric. It's what makes curry yellow. Google it. One of the theories as to why East Indians have so little Alzheimer's is that the tumeric (and in my opinon other common spices like ginger) have an anti-inflamatory effect on the body and on the brain.

also no secret that nature provides us with many many natural anti-inflammatories. Those who pursue this avenue benefit, those who do not, may fall prey to expensive and needless toxic medications.

http://www.stopinflammation.com/
Read about Jack's new book - Feed Your Genes Right


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The Purpose of This Site
A few years ago, chronic inflammatory diseases were defined largely by arthritis and other " itis" diseases. Over the past several years, medicine has started to recognize the fundamental role of inflammation in nearly every disease process. Researchers and physicians have been redefining heart disease, Alzheimer's, and even diabetes and obesity as inflammatory disorders. Much of this new view of chronic inflammation in degenerative diseases has come from research showing that people with inflammatory diseases have elevated blood levels of C-reactive protein and other markers of inflammation. Relatively minor inflammatory disorders, such as injuries or allergies, can set the stage for more serious, chronic inflammatory diseases, and many inflammatory disorders actually develop as clusters -- hence, the inflammation syndrome. This site introduces you to the relationships between diet, inflammation, and disease.
About the Book
The Inflammation Syndrome: The Complete Nutritional Program to Prevent and Reverse Heart Disease, Arthritis, Skin Problems, Allergies and Asthma (March 2003 publication) describes the dietary imbalances and nutrient deficiencies that set the stage for chronic inflammatory diseases. Such diets typically contain inflammation-promoting dietary oils and fats and large amounts of sugars and refined carbohydrates. The book's Anti-Inflammation Syndrome diet plan recommends a wholesome anti-inflammatory diet emphasizing fish, chicken, vegetables, and olive oil. The book also recommends specific types of supplements that studies have found to have anti-inflammatory properties.

Who is Jack Challem?
Jack Challem, The Nutrition Reporter™, is a "journalist-expert" and leading health reporter with almost 30 years of experience reporting the latest research on nutrition, vitamins, and minerals. He is the author of The Inflammation Syndrome (John Wiley & Sons, March 2003) and the lead author of the best-selling Syndrome X: The Complete Nutritional Program to Prevent and Reverse Insulin Resistance,(John Wiley & Sons, 2000). He publishes The Nutrition Reporter™ newsletter and writes for many magazines, including Natural Health, GreatLife, Let's Live, and Modern Maturity. His scientific articles have appeared in Free Radical Biology & Medicine, Journal of Orthomolecular Medicine, Medical Hypotheses, and other journals, and he had made original scientific contributions related to the understanding of nutrition in human evolution.

I try to use 1/2 teaspoon of tumeric per day in food or taken in honey.
Its also highly effective for cardiovascular inflamatory conditions or arthritis.
Another such anti inflamatory useful for cardiovascular problems is Hawthorne.
There are peer-reviewed studies documenting the beneficial effects of both.

Alzheimer's: A Form Of Diabetes?
(note that diabetes is an autoimmune condition and toxic exposures such as mercury are a known cause- type II is very treatable
with most recovering if properly treated and even type I can be helped a lot by treatments such as glyconutrients and detox)

An intriguing new study from Brown University has linked declining insulin production in the brain to Alzheimer's disease, leading inevitably to the question -- could Alzheimer's be a form of diabetes?
"Insulin disappears early and dramatically in Alzheimer's disease," says senior researcher Suzanne M. de la Monte, a neuropathologist at Rhode Island Hospital and a professor of pathology at Brown University Medical School.
"And many of the unexplained features of Alzheimer's, such as cell death and tangles in the brain, appear to be linked to abnormalities in insulin signaling. This demonstrates that the disease is most likely a neuroendocrine disorder, or another type of diabetes."
The Brown researchers found that brain insulin produced by patients with Alzheimer's disease tends to be below normal levels and that brain levels of insulin and its related cellular receptors fall precipitously during the early stages of Alzheimer's.
Insulin levels then continue to drop progressively as the disease becomes more severe -- adding to evidence that Alzheimer's might be a new form of diabetes.
In the study, the scientists autopsied the brain tissue of 45 patients diagnosed with different degrees of Alzheimer's called "Braak Stages." They compared those tissues to samples taken from individuals with no history of the disease.
When the team analyzed insulin and insulin receptor function in the frontal cortex of the brain, a major area affected by Alzheimer's, they found that as the severity of Alzheimer's increased, the levels of insulin receptors and the brain's ability to respond to insulin decreased.
"In the most advanced stage of Alzheimer's, insulin receptors were nearly 80 percent lower than in a normal brain," de la Monte said.
In addition, the researchers found two abnormalities related to insulin in Alzheimer's. First, levels of insulin dropped as the disease progressed. Second, insulin and its related protein -- insulin-related growth factor-I -- lose the ability to bind to cell receptors. This creates a resistance to the insulin growth factors, causing the cells to malfunction and die.
In addition, the Brown University team found that low levels of acetylcholine -- a known sign of Alzheimer's -- are directly linked to this loss of insulin.
"We're able to show that insulin impairment happens early in the disease," de la Monte said. "We're able to show it's linked to major neurotransmitters responsible for cognition. We're able to show it's linked to poor energy metabolism, and it's linked to abnormalities that contribute to the tangles characteristic of advanced Alzheimer's disease.
"This work ties several concepts together and demonstrates that Alzheimer's disease is quite possibly a Type 3 diabetes."
Experts say the work may lead to an insulin-like medication that can be injected into early Alzheimer's patients to prevent memory loss.
The report appears in the Journal of Alzheimer's Disease.