I wonder if there wouldn't be a benefit to reducing production of excess Oxygen Free Radicals by helping the Krebs energy to produce fewer OFRs, or to help reduce production of OFR in hypoxic conditions in the cells. To that end research on Idebenone seems encouraging.
http://smart-drugs.net/JamesSouth-idebenone.htm Co Q10’s pro-oxidant action
"When blood flow is seriously reduced to any part of the body, as in a heart attack, stroke, trauma, shock, or chronic poor blood circulation- cellular/ mitochondrial oxygen (O2) levels quickly drop in the affected region. Yet because oxygen is seven to eight times more soluble in the lipid zones of cell membrane, compared to the watery compartments of the cell, there is still sufficient oxygen remaining in the membranes of cells and organelles, as well as in the electron transport chain, to auto-oxidize Co Q10. As the Co Q10 auto-oxidizes, hydrogen peroxide, superoxide and hydroxl free radicals are rapidly formed in massive numbers. These free radicals quickly damage cell/ organelle structure and function, as well as rapidly halt ATP energy generation by the electron transport chain.
Brain and spinal cord cells are especially prone to such damage, and may be irreparably damaged or even destroyed within minutes.
Why Idebenone is superior to Co Q10
Studies have shown that under the same cellular low oxygen conditions that cause Co Q10 to act as a pro-oxidant producer of damaging free radicals, Idebenone prevents the free radical dam-age and maintains relatively normal cell ATP levels. In short, while Idebenone can effectively substitute for Co Q10's positive and life essential functions, it doesn't have Co Q10's free radical producing and energy crashing "dark side" which occurs under hypoxic (low oxygen) conditions."