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Celebration Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Mar-29-06 05:48 PM
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Two Wound Studies with Laser and LED
Just a couple of the studies on this--first low level laser with diabetic rats--


Photomed Laser Surg. 2005 Apr;23(2):187-90.
Related Articles, Links


Effect of low intensity helium-neon (He-Ne) laser irradiation on diabetic wound healing dynamics.

Maiya GA, Kumar P, Rao L.

Department of Physiotherapy, MAHE University, Manipal, India. ajmaiya@yahoo.com

OBJECTIVE: The aim of this study was to determine the effect of low-energy He-Ne laser treatment on wound healing dynamics (histological and biochemical) in diabetic rats. BACKGROUND DATA: Low-energy laser photostimulation at certain wavelengths can enhance tissue repair by releasing growth factors from fibroblasts and can facilitate the healing process of diabetic wounds. MATERIALS AND METHODS: A circular 4 cm2 excisional wound was created on the dorsum of the experimentally (Alloxan)-induced diabetic rats. In the study group (N = 24) the wound was treated with He-Ne laser (632.8 nm wavelength) at a dose of 4.8 J/cm2 for 5 days a week until the wound healed completely. The control group (N = 24) was sham-irradiated. The results were statistically analyzed by an independent t test for biochemical analysis and the nonparametric Mann-Whitney U test for histopathological parameters. RESULTS: The analysis of the biochemical parameters and histopathological parameters of the wounds showed that the laser-treated group healed faster and better as compared to the control group (p < 0.0001). The laser-treated group healed on average by the 18th day whereas, the control group healed on average by the 59th day. CONCLUSION: Laser photostimulation promotes the tissue repair process of diabetic wounds.

PMID: 15910184


Now Light Emitting diodes on animals and humans

J Clin Laser Med Surg. 2001 Dec;19(6):305-14.

Effect of NASA light-emitting diode irradiation on wound healing.

Whelan HT, Smits RL Jr, Buchman EV, Whelan NT, Turner SG, Margolis DA, Cevenini V, Stinson H, Ignatius R, Martin T, Cwiklinski J, Philippi AF, Graf WR, Hodgson B, Gould L, Kane M, Chen G, Caviness J.

Department of Neurology, Medical College of Wisconsin, Milwaukee 53226, USA.

OBJECTIVE: The purpose of this study was to assess the effects of hyperbaric oxygen (HBO) and near-infrared light therapy on wound healing. BACKGROUND DATA: Light-emitting diodes (LED), originally developed for NASA plant growth experiments in space show promise for delivering light deep into tissues of the body to promote wound healing and human tissue growth. In this paper, we review and present our new data of LED treatment on cells grown in culture, on ischemic and diabetic wounds in rat models, and on acute and chronic wounds in humans. MATERIALS AND METHODS: In vitro and in vivo (animal and human) studies utilized a variety of LED wavelength, power intensity, and energy density parameters to begin to identify conditions for each biological tissue that are optimal for biostimulation. Results: LED produced in vitro increases of cell growth of 140-200% in mouse-derived fibroblasts, rat-derived osteoblasts, and rat-derived skeletal muscle cells, and increases in growth of 155-171% of normal human epithelial cells. Wound size decreased up to 36% in conjunction with HBO in ischemic rat models. LED produced improvement of greater than 40% in musculoskeletal training injuries in Navy SEAL team members, and decreased wound healing time in crew members aboard a U.S. Naval submarine. LED produced a 47% reduction in pain of children suffering from oral mucositis. CONCLUSION: We believe that the use of NASA LED for light therapy alone, and in conjunction with hyperbaric oxygen, will greatly enhance the natural wound healing process, and more quickly return the patient to a preinjury/illness level of activity. This work is supported and managed through the NASA Marshall Space Flight Center-SBIR Program.

PMID: 11776448


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Redstone Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Mar-29-06 05:54 PM
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1. Hey, that's a real breakthrough, isn't it? Good to see our tax $$
being used for something useful for a change.

Redstone
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Celebration Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Mar-29-06 06:35 PM
Response to Reply #1
2. NASA
They have been at the forefront in research using light emitting diodes in the U.S.A.

It's just really too bad that only a tiny fraction of the people here who have non-healing wounds are even offered this type of treatment with either low level laser therapy or LED light. And many go on to lose limbs. At least some of them would have been helped by this treatment.

Topical hyperbaric oxygen is another interesting treatment. And, in Israel there have been impressive studies using a combination of the two modalities (LLLT and topical hyperbaric oxygen).

Here is a website on topical hyperbaric oxygen--

http://researchnews.osu.edu/archive/oxywound.htm

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trotsky Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Mar-29-06 09:13 PM
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3. Not quite so promising.
http://www.aetna.com/cpb/data/CPBA0604.html

Several meta-analyses have examined the evidence supporting the use of low-level (cold) lasers, including low-level infrared lasers, for treatment of chronic non-healing wounds. See CPB 363 - Cold Laser Therapy. These meta-analyses are unanimous in concluding that there is insufficient evidence to support low-level laser in the treatment of chronic venous ulcers or other chronic non-healing wounds.

There is no evidence that infrared light therapy is any more effective than other heat modalities in the symptomatic relief of musculoskeletal pain. Glasgow (2001) reported on the results of a randomized controlled clinical trial of low-level infrared therapy in 24 subjects with experimentally induced muscle soreness, and found no significant differences between treatment and placebo groups.


And since there is no financial advantage for an insurance group to want a patient's wound NOT to heal (just increases the risk of infection and much more expensive treatment later), it's hard to dismiss this as "big pharma big insurance big government hooey."
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Celebration Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Mar-29-06 10:37 PM
Response to Reply #3
4. Aetna
So because Aetna denied it you say not quite so promising?? Old meta analyses include studies that were done before effective dosages were established. Thus they were irrelevant.


http://www.laser.nu/lllt/LLLT_critic_on_critics.htm

The purpose of our criticism is described in the Introduction - we wish to draw the reader's attention to the fact that many negative studies are poorly structured and are therefore largely irrelevant, even though they constantly feature in bibliographies and reading lists and are cited as "evidence" that LLLT does not work. Few people appear to have actually read them. As we see it, it is high time they were weeded out so that they can no longer function as traveller's tales in the future.



The dosages were being worked out in the earlier studies. Too low of a dose and it is just like a placebo treatment.

Anyway, this is an example of something that isn't "proven" yet, to the satisfaction of insurers, in the USA. However it is used in other countries quite a bit and has no known side effects.

Another study--

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10469307&query_hl=24&itool=pubmed_docsum

Recurrent infection with herpes simplex virus is a common disease. Recently, alternative therapies have been introduced. Among those, low-intensity laser therapy mainly used for the acceleration of wound healing and in pain therapy has previously been shown to be of benefit in herpes zoster infections. In this study we evaluated the influence of low-intensity laser therapy (wavelength 690 nm, intensity: 80 mW per cm2, dose: 48 J per cm2) in 50 patients with recurrent perioral herpes simplex infection (at least once per month for more than 6 mo) in a randomized, double-blind placebo-controlled trial design. Patients in the laser group received daily irradiations for 2 wk, whereas patients in the placebo group were sham-irradiated. After completion of the laser/sham treatment, patients were asked to return to the Department of Dermatology, University of Vienna Medical School at the time of recurrence. All except two patients completed the study and were monitored for 52 wk. The median recurrence-free interval in the laser-treated group was 37.5 wk (range: 2-52 wk) and in the placebo group 3 wk (range: 1-20 wk). This difference was found to be statistically significant (p < 0.0001; Wilcoxon's Rank Sum Test). In conclusion, we demonstrated that a total of 10 irradiations with low-intensity laser therapy significantly lowers the incidence of local recurrence of herpes simplex infection. Since this athermic phototherapeutic modality represents a safe, noninvasive treatment, it might be considered as an alternative to established therapeutic regimens in this indication.


Anyway, thanks for making the point for me. This is something that is "unproven" (in the USA), and a good example of something that would probably be a good thing to try if one had a non-healing wound, given its history of use in other countries and positive studies when the correct dosage is use. The devices are cleared by the FDA for other uses here. So this is sort of like giving anti psychotic meds to ADHD kids--oh, I forget, except that they are dangerous and this is not.


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Celebration Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Mar-29-06 10:49 PM
Response to Reply #3
5. Cleveland Clinic
Must not have gotten confused like Aetna over all those meta analyses--

http://www.jhconline.com/article-novdec2005-contractingnews.asp

Cleveland Clinic employs Anodyne Therapy System
Cleveland Clinic Health System installed the Anodyne Therapy System from Tampa Fla-based Anodyne Therapy, LLC in its home health agency, wound care, and Wooster Podiatry and Physical Therapy clinics. Cleveland Clinic has been using the Anodyne Therapy System on an evaluation basis since April 2005 with its advanced wound care protocols and physical therapy interventions to increase circulation for wound healing, pain reduction and balance improvements.


This is an LED device. Now, really, Anodyne has FDA clearance for some kinds of pain, not wound healing (to my knowledge), but according to this website, Cleveland Clinic also uses it for wound healing. However, I am not sure about insurance coverage. Since it is being used on an evaluation basis, they must have thought it was a decent thing to try (I agree).

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trotsky Donating Member (1000+ posts) Send PM | Profile | Ignore Thu Mar-30-06 08:04 AM
Response to Reply #5
6. There's nothing wrong with trying.
But I'm just pointing out that the studies are far from conclusive. If you have research dollars to spend, it's hard to say at this point whether this or other technologies should be looked at.

Just because someone points out conflicting evidence doesn't mean they're attacking your pet treatment.
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