'Junk' DNA proves functional

In a paper published in Genome Research on Nov. 4, scientists at the Genome Institute of Singapore (GIS) report that what was previously believed to be "junk" DNA is one of the important ingredients distinguishing humans from other species.

More than 50 percent of human DNA has been referred to as "junk" because it consists of copies of nearly identical sequences. A major source of these repeats is internal viruses that have inserted themselves throughout the genome at various times during mammalian evolution.

Using the latest sequencing technologies, GIS researchers showed that many transcription factors, the master proteins that control the expression of other genes, bind specific repeat elements. The researchers showed that from 18 to 33% of the binding sites of five key transcription factors with important roles in cancer and stem cell biology are embedded in distinctive repeat families.

Over evolutionary time, these repeats were dispersed within different species, creating new regulatory sites throughout these genomes. Thus, the set of genes controlled by these transcription factors is likely to significantly differ from species to species and may be a major driver for evolution.

This research also shows that these repeats are anything but "junk DNA," since they provide a great source of evolutionary variability and might hold the key to some of the important physical differences that distinguish humans from all other species.

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http://www.physorg.com/news145038245.html

Why do humans always assume that because WE can't see a purpose for something, it must not have any? It's why we have managed to wreck most of the earth's ecosystems - we don't have a clue what most of the parts are for.

The minute I heard the term 'junk DNA', I knew there was a use for it, but since we didn't know what it was, we just casually dismissed it. :mad:

We called it "junk" as long as it seemed to serve no purpose, and I presume that we'll stop now that we know otherwise.