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Evolution Of The Human Appendix: A Biological 'Remnant' No More

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steven johnson Donating Member (1000+ posts) Send PM | Profile | Ignore Fri Aug-21-09 07:33 PM
Original message
Evolution Of The Human Appendix: A Biological 'Remnant' No More
Edited on Fri Aug-21-09 07:38 PM by steven johnson
There are at least two functions for the human appendix that have been theorized: a reservoir for 'good' bacteria to repopulate the gut after a severe GI infection; as a digestive organ in more primative mammals.

It also has significant immune functions particularly B-lymphocyte-mediated immune responses and extrathymically derived T-lymphocytes.
http://www.ncbi.nlm.nih.gov/pubmed/15228837




ScienceDaily (Aug. 21, 2009) — The lowly appendix, long-regarded as a useless evolutionary artifact, won newfound respect two years ago when researchers at Duke University Medical Center proposed that it actually serves a critical function. The appendix, they said, is a safe haven where good bacteria could hang out until they were needed to repopulate the gut after a nasty case of diarrhea, for example.

Using a modern approach to evolutionary biology called cladistics, which utilizes genetic information in combination with a variety of other data to evaluate biological relationships that emerge over the ages, Parker and colleagues found that the appendix has evolved at least twice, once among Australian marsupials and another time among rats, lemmings and other rodents, selected primates and humans. "We also figure that the appendix has been around for at least 80 million years, much longer than we would estimate if Darwin's ideas about the appendix were correct."

Darwin theorized that the appendix in humans and other primates was the evolutionary remains of a larger structure, called a cecum, which was used by now- extinct ancestors for digesting food. The latest study demonstrates two major problems with that idea. First, several living species, including certain lemurs, several rodents and a type of flying squirrel, still have an appendix attached to a large cecum which is used in digestion. Second, Parker says the appendix is actually quite widespread in nature. "For example, when species are divided into groups called 'families', we find that more than 70 percent of all primate and rodent groups contain species with an appendix." Darwin had thought that appendices appeared in only a small handful of animals.





http://www.sciencedaily.com/releases/2009/08/090820175901.htm">Evolution Of The Human Appendix: A Biological 'Remnant' No More
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hlthe2b Donating Member (1000+ posts) Send PM | Profile | Ignore Fri Aug-21-09 07:37 PM
Response to Original message
1. this is new? I learned this in medical training, well let's just say
a couple of decades ago....;)
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Occulus Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-23-09 02:37 AM
Response to Reply #1
3. Are there consequences for those of us who have had the appendix removed?
Mine was || that close to bursting when my doctor cut it out. The symptoms were more painful than anything else I remember.
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hlthe2b Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-23-09 09:17 AM
Response to Reply #3
4. Overtly, no, and an infected appendix MUST be removed..
as it is life threatening. The seemingly non-ncecessity of the organ has, like tonsills and to a much lesser degree, the spleen, led for some time to a fairly dismissive attitude towards removal. This just serves to remind surgeons to be certain removal is absolutely necessary, as there are some functions which continue to work best with its presence.
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knitter4democracy Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Aug-22-09 09:51 PM
Response to Original message
2. But when it goes bad . . .
Ten years of chronic appendicitis, and let's just say I'm really glad that thing's out of me.
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hlthe2b Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-23-09 09:21 AM
Response to Reply #2
5. Yes, absolutely. Unfortunately many GI infections can mimick
appendicitis due to serious bacterial diarrheal infections(toxigenic E. coli, Yersinnia infections, sometimes Campylobacter) and once in the abdomen, a surgeon will often see a non-infected, pink, healthy appendix that they will remove because they are "there." This should serve to give them pause about removing a healthy organ as a "precaution."
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knitter4democracy Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Aug-23-09 02:57 PM
Response to Reply #5
6. In my case, the appendicitis mimicked endometriosis.
For ten years, we kept trying to treat it like it was endo with little success (which, unfortunately, is common in endo anyway). When I finally convinced the surgeon to go in and take out whatever was hurting me so damn bad (no, I really *like* passing out from pain :eyes: ), he couldn't find any endometriosis, just lots of inflammation. It was the resident who noticed that my appendix was in the wrong spot, and when he went to move it and just tack it down, he found that it had glued itself to my pelvic wall. It took him a bit to get it out, and when he did, he and the surgeon and the med student said it was the worst they'd ever seen. The pathologist agreed and said it had been that way for a long time.

So, not everyone gets theirs taken out just because a surgeon is in there. Some of us have to beg first. :)
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