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uppityperson Donating Member (1000+ posts) Send PM | Profile | Ignore Tue May-20-08 07:39 PM
Original message
Glioma. Wtf is a Glioma? Here you go...
Edited on Tue May-20-08 07:48 PM by uppityperson
Wiki has a pretty good definition, so will start with them.

A glioma is a type of primary central nervous system (CNS) tumor that arises from glial cells.
http://en.wikipedia.org/wiki/Glioma

What are "glial cells"? There are lots of glia, or glial cells, in the CNS, and they do lots of things to support neurons. Neurons are the nerve impulse parts of the CNS. Glia are the support for them.

Glial cells, commonly called neuroglia or simply glia (Greek for "glue"), are non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. In the human brain, glia are estimated to outnumber neurons by about 10 to 1.<1>

Glial cells provide support and protection for neurons, the other main type of cell in the nervous system. They are thus known as the "glue" of the nervous system. The four main functions of glial cells are to surround neurons and hold them in place, to supply nutrients and oxygen to neurons, to insulate one neuron from another, and to destroy pathogens and remove dead neurons. http://en.wikipedia.org/wiki/Glia




http://faculty.washington.edu/chudler/glia.html The brain is made up of more than just nerve cells (neurons). Although there are about 100 billion neurons in the brain, there are about 10 to 50 times that many glial cells in the brain. But do you hear much about glia? NO! Because neurons get all the attention, you don't hear too much about glia. Although glia cells DO NOT carry nerve impulses (action potentials) they do have many important functions. In fact, without glia, the neurons would not work properly!
Types and Functions of Glia

* Astrocyte (Astroglia): Star-shaped cells that provide physical and nutritional support for neurons: 1) clean up brain "debris"; 2) transport nutrients to neurons; 3) hold neurons in place; 4) digest parts of dead neurons; 5) regulate content of extracellular space
* Microglia: Like astrocytes, microglia digest parts of dead neurons.
* Oligodendroglia: Provide the insulation (myelin) to neurons in the central nervous system.
* Satellite Cells: Physical support to neurons in the peripheral nervous system.
* Schwann Cells: Provide the insulation (myelin) to neurons in the peripheral nervous system



Gliomas can be of different types, depending on which type cell is involved, which type is multiplying rapidly, has become cancerous.

Gliomas are graded into malignant and benign. Malignant are worse, have reverted to a faster growing form of the cells. Overall, few patients survive beyond 3 years.

Mayo Clinic in MN has some good info on types, diagnosis, treatment, etc.

http://www.mayoclinic.org/glioma/
About Gliomas (Primary Brain Tumors)

A tumor is a mass or growth of abnormal cells. Tumors found in the brain typically are categorized as primary or secondary. Gliomas (primary brain tumors) start in the brain or spinal cord tissue. They can spread within the nervous system but do not spread outside the nervous system. Gliomas can be either benign (slow growing) or malignant (fast growing). Annually, about 17,000 Americans are diagnosed with a primary brain tumor.

Brain tumors can be challenging to treat, but many are treated successfully. Also, new technology helps physicians target tumors more precisely. Innovative treatments under investigation offer hope for the future.


For those who would like to read more, Chicago Institute of Neurosurgery and Neuroresearch has info on types, symptoms, diagnosis and treatment.
http://www.cinn.org/tumor/diagnoses/glioma-tumor.html

Edited to add, best of luck Sen Kennedy, and all who have cancer. And thank you Sen Kennedy.
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uppityperson Donating Member (1000+ posts) Send PM | Profile | Ignore Tue May-20-08 07:51 PM
Response to Original message
1. Thanks for the recs. My little monkey mind deals with stress by trying to figure it out.
As well as being very sad. Sorry if this offends anyone, just doing what I do, gathering health/disease info, and passing it on. Trying to make some sense out of a very sad thing.
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roguevalley Donating Member (1000+ posts) Send PM | Profile | Ignore Tue May-20-08 09:06 PM
Response to Reply #1
6. Chris Dodd says someone in his office has a dad who has this and
has lived with it 21 years.
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mzmolly Donating Member (1000+ posts) Send PM | Profile | Ignore Tue May-20-08 09:24 PM
Response to Reply #6
7. Awesome to learn,
thanks RV. :hi:
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Iris Donating Member (1000+ posts) Send PM | Profile | Ignore Tue May-20-08 09:37 PM
Response to Reply #6
10. so there's hope!
Thanks for sharing this!
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bleever Donating Member (1000+ posts) Send PM | Profile | Ignore Tue May-20-08 08:26 PM
Response to Original message
2. Thank you for the info.
Our energy is with you, Sen. Kennedy.
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Olney Blue Donating Member (1000+ posts) Send PM | Profile | Ignore Tue May-20-08 08:32 PM
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3. Thank you for the information. I hope the best for the Senator (my hero).
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cornermouse Donating Member (1000+ posts) Send PM | Profile | Ignore Tue May-20-08 08:41 PM
Response to Original message
4. Glioma.
The most common primary brain tumors are gliomas, meningiomas, pituitary adenomas, vestibular schwannomas, and primitive neuroectodermal tumors (medulloblastomas). The term glioma includes astrocytomas, oligodendrogliomas, ependymomas, and choroid plexus papillomas...

...The following symptoms are most common:

* Headache

* Weakness

* Clumsiness

* Difficulty walking

* Seizures

Other nonspecific symptoms and signs include the following:

* Altered mental status: changes in concentration, memory, attention, or alertness

* Nausea, vomiting: especially early in the morning

* Abnormalities in vision

* Difficulty with speech

* Gradual changes in intellectual or emotional capacity

In many people, the onset of these symptoms is very gradual and may be overlooked by both the person with the brain tumor and the family. Occasionally, however, these symptoms appear more rapidly. In some instances, the person acts as if he or she is having a stroke...

...The long-term survival rate (greater than five years) for people with primary brain cancer is less than 10% despite aggressive surgery, radiation, and chemotherapy.
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SoDesuKa Donating Member (1000+ posts) Send PM | Profile | Ignore Tue May-20-08 09:06 PM
Response to Reply #4
5. Vestibular Schwannomas
Are there other types of schwannomas besides vestibular ones?
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uppityperson Donating Member (1000+ posts) Send PM | Profile | Ignore Tue May-20-08 09:25 PM
Response to Reply #5
9. Yes, also Cranial Nerves 5, 7, other
Schwann cells make mylein sheaths that cover peripheral nerves.
Looks like yes, they go on other cranial nerves. Vestibulochocular (8), trigeminal (5), facial (7), other. http://www.thamburaj.com/schwannomas.htm
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mzmolly Donating Member (1000+ posts) Send PM | Profile | Ignore Tue May-20-08 09:25 PM
Response to Original message
8. Sounds like the Mayo has much experience treating this kind of cancer?
Mayo Clinic is one of the world's leading brain tumor treatment and research centers. Mayo Clinic in Rochester, Minn., is ranked No. 1 in Neurology and Neurosurgery by U.S. News and World Report.

Each year, the more than 80 experienced and highly trained doctors on the brain tumor treatment team care for more than 4,000 adults and children who have gliomas and other brain and nervous system tumors.

World-renowned brain tumor specialists from neurology, neurosurgery, radiology, neuropathology, radiation therapy, medical oncology, psychology, and brain rehabilitation work together to deliver the best treatment options for each patient. In Mayo Clinic's efficient system, testing and treatment can usually be done in days, not months.

Mayo doctors and scientists are active in the latest research on brain tumors. Mayo Clinic Cancer Center is the only multisite national cancer center and one of only four cancer centers to receive a National Cancer Institute-sponsored Specialized Program of Research Excellence (SPORE) grant for brain cancer research. Patients at Mayo have access to new research through Mayo's participation in cooperative clinical trials networks, including the North Central Cancer Treatment Group.


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Horse with no Name Donating Member (1000+ posts) Send PM | Profile | Ignore Wed May-21-08 01:04 AM
Response to Original message
11. A malignant glioma
Is basically the same as a glioblastoma...and it is the worst kind you can have.
>>>snip
Kennedy's age and the mention of upfront chemotherapy mean the glioma is almost certainly one of the two worst forms: a glioblastoma — the fastest-killing brain tumor, known for claiming entertainer Ethel Merman and Republican political strategist Lee Atwater — or the only somewhat less aggressive anaplastic astrocytoma, Subramaniam said.

Malignant glioma "usually is a synonym for a glioblastoma," agreed Dr. Robert Laureno, neurology chairman at Washington Hospital Center in the nation's capital.

The American Cancer Society puts the five-year survival rate for patients over age 45 at 16 percent for those with anaplastic astrocytomas, and 2 percent or less for those with glioblastomas.

http://ap.google.com/article/ALeqM5gx6Bsx3wrVp3rki8h6XVR2sptB9wD90PL4R00
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