Marijuana Could Prevent Alzheimer's, New Study

Some interesting comments on this http://science.slashdot.org/article.pl?sid=09/01/27/1354225">here


A funny Alzheimers joke found here:http://science.slashdot.org/article.pl?sid=09/01/16/1347230&tid=272">"Coffee Can Reduce the Risk of Alzheimer's"

An old couple both have Alzheimers. They're watching TV and an advert for a burger joint comes on.

"Hey," the man says, "burgers would be great! Could you make some? I'd like lettuce, tomatoes and onions on mine. Don't forget! Lettuce. Tomatoes. Onions."

Wife replies "Lettuce, tomatoes and onions. Got it. Lettuce, tomatoes and onions."

About 2 hours later she comes out of the kitchen and hands him a plate of bacon and eggs. "You idiot," he cries, "you forgot the toast!"

:rofl:

pot preventing memory loss

unless you're afraid that it will lead to using coke or Oxycontin.

:sarcasm:

http://www.ncbi.nlm.nih.gov/pubmed/17959812?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Cannabinoids elicit antidepressant-like behavior and activate serotonergic neurons through the medial prefrontal cortex.Bambico FR, Katz N, Debonnel G, Gobbi G.
Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University, Montréal, Quebec, Canada H3A 1A1.

Preclinical and clinical studies show that cannabis modulates mood and possesses antidepressant-like properties, mediated by the agonistic activity of cannabinoids on central CB1 receptors (CB1Rs). The action of CB1R agonists on the serotonin (5-HT) system, the major transmitter system involved in mood control and implicated in the mechanism of action of antidepressants, remains however poorly understood. In this study, we demonstrated that, at low doses, the CB1R agonist WIN55,212-2 pyrrolo<1,2,3-de>-1,4-benzoxazinyl]-(1-naphthalenyl) methanone mesylate] exerts potent antidepressant-like properties in the rat forced-swim test (FST). This effect is CB1R dependent because it was blocked by the CB1R antagonist rimonabant and is 5-HT mediated because it was abolished by pretreatment with the 5-HT-depleting agent parachlorophenylalanine. Then, using in vivo electrophysiology, we showed that low doses of WIN55,212-2 dose dependently enhanced dorsal raphe nucleus 5-HT neuronal activity through a CB1R-dependent mechanism. Conversely, high doses of WIN55,212-2 were ineffective in the FST and decreased 5-HT neuronal activity through a CB1R-independent mechanism. The CB1R agonist-induced enhancement of 5-HT neuronal activity was abolished by total or medial prefrontocortical, but not by lateral prefrontocortical, transection. Furthermore, 5-HT neuronal activity was enhanced by the local microinjection of WIN55,212-2 into the ventromedial prefrontal cortex (mPFCv) but not by the local microinjection of WIN55,212-2 into the lateral prefrontal cortex. Similarly, the microinjection of WIN55,212-2 into the mPFCv produced a CB1R-dependent antidepressant-like effect in the FST. These results demonstrate that CB1R agonists possess antidepressant-like properties and modulate 5-HT neuronal activity via the mPFCv.
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http://www.ncbi.nlm.nih.gov/pubmed/17945507?ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Enhancement of endocannabinoid signaling and the pharmacotherapy of depression.Mangieri RA, Piomelli D.
Department of Pharmacology and Center for Drug Discovery, The University of California, Irvine, CA 92697, USA.

Cannabinoids are well known modulators of mood and emotional behavior. Current research supports a role for endocannabinoid signaling in the treatment of depression. Changes in levels of the cannabinoid CB(1) receptor or the endogenous CB(1) receptor ligands, anandamide and 2-AG, are observed both in humans suffering from depression and in animal models of depression, and experimental manipulation of CB(1) receptor signaling has also been shown to affect emotional reactivity in rodents. Importantly, inhibitors of anandamide inactivation have demonstrated efficacy in enhancing stress-coping and mood-related behavior. This article will review these areas of research, highlighting the potential of endocannabinoid metabolism modulators as therapeutics for the treatment of depression.

http://www.congressunderfire.com/dc/dcboard.php?az=show_topic&forum=109&topic_id=91&mesg_id=91&page=

Than the stuff from the 60's!:eyes:

Now it's 2 trillion times more powerful.

How will we protect the CHILDREN!!!!???

:kick:

:)