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Mike 03

(16,616 posts)
Tue Mar 10, 2020, 10:20 AM Mar 2020

Coronavirus is mysteriously sparing kids and killing the elderly. Understanding why may help defeat

Washington Post
March 10, 2020 at 7:00 a.m. MST

Full headline: Coronavirus is mysteriously sparing kids and killing the elderly. Understanding why may help defeat the virus.



One of the few mercies of the spreading coronavirus is that it leaves young children virtually untouched — a mystery virologists say may hold vital clues as to how the virus works.

In China, only 2.4 percent of reported cases were children and only 0.2 percent of reported cases were children who got critically ill, according to the World Health Organization. China has reported no case of a young child dying of the disease covid-19.

The new coronavirus has proved especially deadly on the other end of the age spectrum. The fatality rate in China for those over 80 is an estimated 21.9 percent, per the WHO. For ages 10 to 39, however, the fatality rate is roughly 0.2 percent, according to a separate study drawing on patient records of 44,672 confirmed cases.

That means the new coronavirus is behaving very differently from other viruses, like seasonal influenza, which are usually especially dangerous for the very young and very old.

“With respiratory infections like this, we usually see a U-shaped curve on who gets hits hardest. Young children at one end of the U because their immune systems aren’t yet developed and old people at the other end because their immune systems grow weaker,” said Vineet Menachery, a virologist at the University of Texas Medical Branch. “With this virus, one side of the U is just completely missing.”


snip

“It’s the aggressive response from their immune system that is damaging them, even more than the infection itself,” Menachery said. “It’s like police responding to a misdemeanor with a SWAT team crashing through the door.”

The question he and others have still struggled to answer, however, is why the baby mice escape unscathed.

Some experts have floated a theory that because children are so heavily exposed to four other mild coronaviruses, which circulate every year and cause the common cold, that may give kids some kind of strengthened immunity. But many have doubts about that argument because adults catch the common cold coronaviruses too, and the immune systems of children — especially under the age of five — are underdeveloped, which should make them more vulnerable, not less.

“If it bears out that kids are less prone to infection, then I suspect there’s something more mechanical than immunological going on,” said Espers, the pediatric infection expert. “Something about the receptors in children’s bodies or their lungs is interfering with the virus’ ability to attach itself.”


More at link: https://www.washingtonpost.com/health/2020/03/10/coronavirus-is-mysteriously-sparing-kids-killing-elderly-understanding-why-may-help-defeat-virus/
12 replies = new reply since forum marked as read
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Coronavirus is mysteriously sparing kids and killing the elderly. Understanding why may help defeat (Original Post) Mike 03 Mar 2020 OP
Thank goodness it's mostly skipping the kids. Magoo48 Mar 2020 #1
Kick dalton99a Mar 2020 #2
This is an important paragraph too: Mike 03 Mar 2020 #3
Asymptomatic or mild symptoms TDale313 Mar 2020 #4
High blood pressure, too spinbaby Mar 2020 #5
Squeeze jberryhill Mar 2020 #6
Love that movie! Nt USALiberal Mar 2020 #10
Earth's way of saving itself from the fossil-fuel generation. lagomorph777 Mar 2020 #7
Lack of receptors in children was my first guess jpak Mar 2020 #8
Alot of adults in China smoke. Like over 50% GusBob Mar 2020 #9
Do people in Italy smoke a lot? I wonder if that does make a big difference. leftyladyfrommo Mar 2020 #12
Hmm. This is turning out to be an interesting Andromeda Strain story. Baitball Blogger Mar 2020 #11

Mike 03

(16,616 posts)
3. This is an important paragraph too:
Tue Mar 10, 2020, 10:23 AM
Mar 2020
But many epidemiologists suspect mild symptoms may simply be masking that children are getting infected the same rates as adults. New data published this week by Chinese researchers showed authorities searching for coronavirus cases based on symptoms found lower rates in kids. But when they relied on contact tracing — testing people who come in contact with a confirmed case — children seemed to be getting infected at the same rate as adults.

TDale313

(7,820 posts)
4. Asymptomatic or mild symptoms
Tue Mar 10, 2020, 10:35 AM
Mar 2020

No evidence they are immune. It’s great kids aren’t getting sick or as sick, but they can still be carriers.

spinbaby

(15,090 posts)
5. High blood pressure, too
Tue Mar 10, 2020, 10:38 AM
Mar 2020

In China they noticed that a higher than expected percentage of Covid-19 patients suffered from high blood pressure. If you have high blood pressure, this is added incentive to get it under control.

jpak

(41,759 posts)
8. Lack of receptors in children was my first guess
Tue Mar 10, 2020, 10:41 AM
Mar 2020

Why the elderly are more prone to infection?

Abundant receptors and aging immune systems?

GusBob

(7,286 posts)
9. Alot of adults in China smoke. Like over 50%
Tue Mar 10, 2020, 10:41 AM
Mar 2020

I don't think many kids do, other than second-handed


Along with that reported fibrosis of the lungs business in Chinese autopsies, I'm thinking that smoking is a risk factor in this

leftyladyfrommo

(18,870 posts)
12. Do people in Italy smoke a lot? I wonder if that does make a big difference.
Tue Mar 10, 2020, 11:16 AM
Mar 2020

They have the problem there of having an older population.

Baitball Blogger

(46,758 posts)
11. Hmm. This is turning out to be an interesting Andromeda Strain story.
Tue Mar 10, 2020, 11:12 AM
Mar 2020

What do we lose in our lungs as we get older?

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