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abqtommy

(14,118 posts)
Wed Mar 18, 2020, 07:48 AM Mar 2020

Japanese flu drug 'clearly effective' in treating coronavirus, says China. From The Guardian...

3-18-20

"Medical authorities in China have said a drug used in Japan to treat new strains of influenza appeared to be effective in coronavirus patients, Japanese media said on Wednesday.

Zhang Xinmin, an official at China’s science and technology ministry, said favipiravir, developed by a subsidiary of Fujifilm, had produced encouraging outcomes in clinical trials in Wuhan and Shenzhen involving 340 patients.

“It has a high degree of safety and is clearly effective in treatment,” Zhang told reporters on Tuesday.


Patients who were given the medicine in Shenzhen turned negative for the virus after a median of four days after becoming positive, compared with a median of 11 days for those who were not treated with the drug, public broadcaster NHK said."

more at link: https://www.theguardian.com/world/2020/mar/18/japanese-flu-drug-clearly-effective-in-treating-coronavirus-says-china

It's good to see more encouraging treatment news each day...

59 replies = new reply since forum marked as read
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Japanese flu drug 'clearly effective' in treating coronavirus, says China. From The Guardian... (Original Post) abqtommy Mar 2020 OP
Give it to us for free, even though we have a president that was plotting to hold you hostage with brewens Mar 2020 #1
I'd be willing to pay a fair market price but you know tRUMP has to get his cut... abqtommy Mar 2020 #2
How long for a new drug to get FDA approval? (n/t) Spider Jerusalem Mar 2020 #3
We have a model for this, from the HIV pandemic. Need to shortcut the process. lagomorph777 Mar 2020 #15
spread the rumor it's a liberal plot, turns people into zombies - half the trumpers will refuse it certainot Mar 2020 #26
If you really want to scare them off tell them it will turn their skin brown. Alwaysna Mar 2020 #29
brown zombies! certainot Mar 2020 #33
Immediate approval for the rich, everyone else?...who knows. C Moon Mar 2020 #45
:D C Moon Mar 2020 #44
It was already being looked at and there is data for use in Rift Valley Fever--a zoonotic viral hlthe2b Mar 2020 #4
Kicking it up. Thank you. Guilded Lilly Mar 2020 #5
This message was self-deleted by its author democratisphere Mar 2020 #6
Anyone more interested in the drug can start here: Act_of_Reparation Mar 2020 #7
it is a pyrazinecarboxamide derivative. progressoid Mar 2020 #9
Pyraznamide has a similar effect on mycobacteria. Act_of_Reparation Mar 2020 #21
This seems huge. Wonder how big their stockpile is, and when they can ramp it up? lostnfound Mar 2020 #8
They can license it videohead5 Mar 2020 #10
This gives me hope. Silver Gaia Mar 2020 #11
That is encouraging news! kentuck Mar 2020 #12
I hope this is solid. Girard442 Mar 2020 #13
drumpf will never go for this, he's got his huge profits already planned. lark Mar 2020 #14
SO don't let him have any. The country needs to rise up if he pulls any more shit like that. lagomorph777 Mar 2020 #16
He's already doing it with the testing and got caught doing this w/the vaccine. lark Mar 2020 #17
They will pay. The Grovelers Of Putin will be cast out like lepers (the way they'd treat lepers). lagomorph777 Mar 2020 #18
I so hope you are right catchnrelease Mar 2020 #38
Feed them Roundup. lagomorph777 Mar 2020 #39
Good idea catchnrelease Mar 2020 #40
Kick and recommend for hope! bronxiteforever Mar 2020 #19
Good news! crickets Mar 2020 #20
Good news! worth watching. bluestarone Mar 2020 #22
KnR SammyWinstonJack Mar 2020 #23
Good news if true... Wounded Bear Mar 2020 #24
yep SCantiGOP Mar 2020 #25
The Guardian is usually pretty good... Wounded Bear Mar 2020 #27
Oh, I agree SCantiGOP Mar 2020 #28
Getting a little sick of the China hate. Sad to see it here too. AtheistCrusader Mar 2020 #43
China stifled their whistle-blower in the early days (he eventually died of the bug) FiveGoodMen Mar 2020 #46
I don't view that as a matter of 'honesty'. It's central planning. AtheistCrusader Mar 2020 #47
Some nerd details intrepidity Mar 2020 #30
Here is another similar hope from France.. pangaia Mar 2020 #31
Nice. And Azithromycin is available by the bucket load too, cheap. AtheistCrusader Mar 2020 #48
Speaking of Azithromycin.. pangaia Mar 2020 #50
I've had it work a few times. AtheistCrusader Mar 2020 #51
People here seem to be overly optimistic about this. It would not make the problem go away. thesquanderer Mar 2020 #32
Sooner is better, for lethality. AtheistCrusader Mar 2020 #49
Seems it only works for people who were tested early on. Temper enthusiasm Roland99 Mar 2020 #34
How does someone turn 'Negative" after they tested positive? I thought they tested Maraya1969 Mar 2020 #35
You would think that every shuttered business would be live love laugh Mar 2020 #36
K & R SunSeeker Mar 2020 #37
Considering the orange shit for brains MyNameGoesHere Mar 2020 #41
I would want more tests from other places rockfordfile Mar 2020 #42
K and R dewsgirl Mar 2020 #52
Gohmert's asking Grokenstein Mar 2020 #53
It only works in early cases. In US we only test in the ICU McCamy Taylor Mar 2020 #54
Encouraging to see China and Japan working together. Fla Dem Mar 2020 #55
This is good news. Aussie105 Mar 2020 #56
trump will make stumbling blocks to inhibit its introduction Demonaut Mar 2020 #57
Other Incouraging Treatments Being Tested Right Now DallasNE Mar 2020 #58
Animal experiments show the potential for teratogenic effects on fetuses TexasTowelie Mar 2020 #59

brewens

(13,598 posts)
1. Give it to us for free, even though we have a president that was plotting to hold you hostage with
Wed Mar 18, 2020, 07:52 AM
Mar 2020

with a vaccine. Please.

lagomorph777

(30,613 posts)
15. We have a model for this, from the HIV pandemic. Need to shortcut the process.
Wed Mar 18, 2020, 09:40 AM
Mar 2020

This is not a risk-free proposition. But the risk tolerance equation is quite different right now.

 

certainot

(9,090 posts)
26. spread the rumor it's a liberal plot, turns people into zombies - half the trumpers will refuse it
Wed Mar 18, 2020, 10:36 AM
Mar 2020

and there will be more for us

hlthe2b

(102,298 posts)
4. It was already being looked at and there is data for use in Rift Valley Fever--a zoonotic viral
Wed Mar 18, 2020, 08:16 AM
Mar 2020

disease. Depending on where they are in that work, it might be expedited under "compassionate" use for trials in COVID-19 by FDA. The issue will be getting supplies ramped up.

Response to abqtommy (Original post)

Act_of_Reparation

(9,116 posts)
7. Anyone more interested in the drug can start here:
Wed Mar 18, 2020, 08:41 AM
Mar 2020
https://en.wikipedia.org/wiki/Favipiravir

The mechanism is unknown, but it seems similar in its effect to Tamiflu--that is, the drug prevents the virus from replicating.

progressoid

(49,991 posts)
9. it is a pyrazinecarboxamide derivative.
Wed Mar 18, 2020, 09:07 AM
Mar 2020

What a coincidence. I was just having a discussion with my local cheesemonger about pyrazinecarboxamide derivatives.

lostnfound

(16,184 posts)
8. This seems huge. Wonder how big their stockpile is, and when they can ramp it up?
Wed Mar 18, 2020, 08:45 AM
Mar 2020

So happy to read this. And since it’s not an American pharmaceutical company, they probably won’t start the price at $100,000 per treatment.

Girard442

(6,081 posts)
13. I hope this is solid.
Wed Mar 18, 2020, 09:23 AM
Mar 2020

I figured that the doctors would shotgun out existing antivirals, hoping for a lucky hit. Maybe this is it.

lark

(23,121 posts)
14. drumpf will never go for this, he's got his huge profits already planned.
Wed Mar 18, 2020, 09:29 AM
Mar 2020

The CDC (at his direction) will say no and then he will say the experts rejected it, ask them, but of course never make them available.

lark

(23,121 posts)
17. He's already doing it with the testing and got caught doing this w/the vaccine.
Wed Mar 18, 2020, 09:45 AM
Mar 2020

He's the dictator in all but name and no one will stop him. Those that could help (R's) are in on the game and the rest don't have sufficient #'s (YET), which is why they are trying to effect a total transfer of wealth to the rich right now.

lagomorph777

(30,613 posts)
18. They will pay. The Grovelers Of Putin will be cast out like lepers (the way they'd treat lepers).
Wed Mar 18, 2020, 09:49 AM
Mar 2020

The GOP will never recover from this.

catchnrelease

(1,945 posts)
38. I so hope you are right
Wed Mar 18, 2020, 04:29 PM
Mar 2020

Sadly people seem to have very short memories. I remember during Junior Bush's term, the various disasters--911, Iraq/Afghanistan, etc etc. People here were saying that there wouldn't be a republican elected again for decades. We got 8 decent years and now look! Even worse than Bush, how can that possibly be? They are like some virulent weed that no matter what you put on it or do to it, it keeps resurrecting! We need to drive a stake through their wizened hearts and cut their heads off!!

crickets

(25,981 posts)
20. Good news!
Wed Mar 18, 2020, 10:05 AM
Mar 2020

Thank you to all of the medical professionals worldwide who are not only taking care of patients but working hard in the labs to find more tools for fighting this illness.

SCantiGOP

(13,871 posts)
25. yep
Wed Mar 18, 2020, 10:36 AM
Mar 2020

I'll believe it when it is the lead story on the Nightly News
(you know, the fake media that we depend on since everything out of the Administration sounds like an LSD-inspired psychotic breakdown).

AtheistCrusader

(33,982 posts)
43. Getting a little sick of the China hate. Sad to see it here too.
Wed Mar 18, 2020, 04:58 PM
Mar 2020

Just.. .for fucking starters, the drug is from Japan. China is simply saying 'hey, this seems to be working'.

I see no reason not to be grateful for this information. They've been through a hell of a thing, and they are finally winning. Please ease up.

FiveGoodMen

(20,018 posts)
46. China stifled their whistle-blower in the early days (he eventually died of the bug)
Wed Mar 18, 2020, 05:22 PM
Mar 2020

I don't think it's any more "China hate" to point out that their government isn't always honest than pointing out Trump's flaws is "America hate"

AtheistCrusader

(33,982 posts)
47. I don't view that as a matter of 'honesty'. It's central planning.
Wed Mar 18, 2020, 05:46 PM
Mar 2020

It is not surprising to me that a country with a centrally planned economy (approaching mixed-market) behaves the same way about Information, as they do economics.

It is unreasonable to expect them to behave like a western democracy. They are not. Hell, there are times *WE* aren't. Our government lies to us, and the world, all the damn time. Distorts and throttles information, all the damn time.

China has just been through some real shit, and it's not entirely over yet. Please cut them some slack. These are good times to hold out a hand and build bridges, rather than kick them when they're down.

Don't forget there are other crises on the back burner. Remember the climate? Even with economic throttling, that's still a problem.
We need to work together as a species.

intrepidity

(7,307 posts)
30. Some nerd details
Wed Mar 18, 2020, 10:53 AM
Mar 2020
Avigan functions as an antiviral drug against RNA viruses. Yousuke Furuta, a researcher at Toyama Chemical research laboratories, has said in a report that Avigan selectively inhibits the RNA-dependent RNA polymerase (RdRp) of RNA viruses. Avigan undergoes an intracellular phosphoribosylation to become an active form and then inhibits RNA polymerase activity.

As the catalytic domain of RdRp is conserved among various types of RNA viruses, that mechanism of action supports a wide spectrum of potential activity. Avigan works against a broad range of influenza virus types as well as West Nile virus, yellow fever, foot-and-mouth disease, and other flaviviruses, arenaviruses, bunyaviruses and alphaviruses, he noted.


https://www.bioworld.com/articles/433290-fujifilm-stock-rises-as-japan-considers-avigan-for-covid-19-treatment

pangaia

(24,324 posts)
31. Here is another similar hope from France..
Wed Mar 18, 2020, 10:54 AM
Mar 2020
laRegione


ABROAD17.03.2020 - 18:35

French virologist: we have medicine against Covid-19
Didier Raoult, director of the Mediterranean Institute for Infections publishes encouraging test results
by @Ansa
Paris - "We know how to heal from Coronavirus": the French virologist Didier Raoult, director of the Mediterranean Institute for infections in Marseille, in the south of France, announces it exclusively to "Les Echos".

Raoult published the results of his clinical trial on the treatment of Coronavirus with chloroquine. Three quarters of the infected patients were no longer carriers of the virus after 6 days of treatment with Plaquenil, one of the commercial names of chloroquine, generally used against malaria: "associated with taking targeted antibiotics against bacterial pneumonia (the azithromycin) - said the infectious disease specialist, whose work is among the most published in the world - has totally healed patients within a week, while 90% of patients who have not taken the drugs are always positive ".

https://www.laregione.ch/estero/estero/1426325/virologo-francese-abbiamo-la-medicina-contro-il-covid-19?fbclid=IwAR3OvKi2prQHDJXrYmn53aEr4Nvj45XzWIQ70o6Zr4bxOS3oFVw7cdsNfgE

AtheistCrusader

(33,982 posts)
48. Nice. And Azithromycin is available by the bucket load too, cheap.
Wed Mar 18, 2020, 05:48 PM
Mar 2020

It's actually pretty weaksauce as antibiotics go. Sounds preventative on the pneumonia side.

pangaia

(24,324 posts)
50. Speaking of Azithromycin..
Wed Mar 18, 2020, 05:56 PM
Mar 2020

I had a really bad cough for weeks.. started before COVID-19 'showed up' in the USA. I do have a a history of pneumonia once in about 1990 - 1 lung. And since then occasionally bronchitis... usually it goes away on its own or if not I get one or another anti-biotics.. the older 10 day kind.. So last Monday, 9 days ago, I went to my doc, he said bronchitis and gave me Azithromycin, which is the newer 5 day version of the older 10 day ones, but it works in the body for 10 days...... The cough etc is much better but not all gone... I'll see how it is thurs the 10th day !

AtheistCrusader

(33,982 posts)
51. I've had it work a few times.
Wed Mar 18, 2020, 06:00 PM
Mar 2020

I'm allergic to Amoxicillin so they give me Azithromycin instead. I get seasonal sinus infections. Usually around Thanksgiving.
Couple times I've had to use something stronger, but it usually does the trick.

thesquanderer

(11,990 posts)
32. People here seem to be overly optimistic about this. It would not make the problem go away.
Wed Mar 18, 2020, 10:55 AM
Mar 2020

Of course, it's very significant, but as the article says:

Patients who were given the medicine in Shenzhen turned negative for the virus after a median of four days after becoming positive, compared with a median of 11 days for those who were not treated with the drug, public broadcaster NHK said.

Meaning: The people who would get better anyway (which is most people) get better sooner. That's helpful, but doesn't directly address either lethality or spread. Though it would allow people to end their quarantines sooner.

In addition, X-rays confirmed improvements in lung condition in about 91% of the patients who were treated with favipiravir, compared to 62% or those without the drug.

I think this is more important, but it is still only a limited treatment, since these numbers indicate that 29% of those who experience lung impairment are still not helped by this drug. 62% see these improvements even without the drug (meaning 38% don't); with the drug only 9% don't (the difference between 100% and 91%); so compared to the current situation, the drug is helping the difference between the 38% and the 9%, which is 29%.

Also worth noting:
Doctors in Japan are using the same drug in clinical studies on coronavirus patients with mild to moderate symptoms... {it is} not as effective in people with more severe symptoms.

but if testing becomes easily and widely available, hopefully it is more often caught before symptoms become severe.

I think this is great, I just caution people about thinking a full cure looks to be around the corner based on this info.

AtheistCrusader

(33,982 posts)
49. Sooner is better, for lethality.
Wed Mar 18, 2020, 05:51 PM
Mar 2020

The longer you have it, the more likely you get secondary shit like pneumonia. So it should indirectly reduce the lethality. (Presuming the initial claims are accurate.

Roland99

(53,342 posts)
34. Seems it only works for people who were tested early on. Temper enthusiasm
Wed Mar 18, 2020, 10:57 AM
Mar 2020
Doctors in Japan are using the same drug in clinical studies on coronavirus patients with mild to moderate symptoms, hoping it will prevent the virus from multiplying in patients.

But a Japanese health ministry source suggested the drug was not as effective in people with more severe symptoms. “We’ve given Avigan to 70 to 80 people, but it doesn’t seem to work that well when the virus has already multiplied,” the source told the Mainichi Shimbun.

The same limitations had been identified in studies involving coronavirus patients using a combination of the HIV antiretrovirals lopinavir and ritonavir, the source added.

Maraya1969

(22,484 posts)
35. How does someone turn 'Negative" after they tested positive? I thought they tested
Wed Mar 18, 2020, 12:18 PM
Mar 2020

for antibodies and those stayed.

live love laugh

(13,119 posts)
36. You would think that every shuttered business would be
Wed Mar 18, 2020, 01:31 PM
Mar 2020

chomping at the bit to contribute to getting this so they can get back to normal.

 

MyNameGoesHere

(7,638 posts)
41. Considering the orange shit for brains
Wed Mar 18, 2020, 04:42 PM
Mar 2020

Has been a racist prick to Asians, we might get it in a decade or so. After this negligent manslaughter he is culpable for, fuck impeachment. Physically dragged from office is the correct remedy.

McCamy Taylor

(19,240 posts)
54. It only works in early cases. In US we only test in the ICU
Wed Mar 18, 2020, 08:34 PM
Mar 2020

when you are already on a ventilator. Meaning that only the rich who can get testing on demand will benefit even if it does work, because they rest of us have to be on death's door to get a test.

Maybe for those in quarantine after a known exposure....

Fla Dem

(23,693 posts)
55. Encouraging to see China and Japan working together.
Wed Mar 18, 2020, 09:57 PM
Mar 2020

While we have a president that can’t work with anyone.

Aussie105

(5,405 posts)
56. This is good news.
Thu Mar 19, 2020, 12:41 AM
Mar 2020

I'm still waiting for the cheap, do it yourself home test to be developed.

Similar to the pregnancy test, it uses sheep red blood cells agglutinating in the presence of a specific chemical. In the pregnancy test, a hormone, in a COVID-19 test, the virus itself, or an antibody produced in response to the virus.
(I think that is how it works, anyway.)

I'd buy a whole stack of them, test myself morning and night. That way I'd know exactly where I stood with this virus.

Demonaut

(8,919 posts)
57. trump will make stumbling blocks to inhibit its introduction
Thu Mar 19, 2020, 12:46 AM
Mar 2020

and they will be valid, no! it's not been tested thoroughly enough, too expensive, rare components, and other delay tactics

DallasNE

(7,403 posts)
58. Other Incouraging Treatments Being Tested Right Now
Thu Mar 19, 2020, 03:04 AM
Mar 2020

Feb 29, 2020 · "Remdesivir is currently in Phase III trials in China and at the University of Nebraska Medical Center (UNMC) in Omaha. Gilead has said they could have 100,000 doses ready in 3 days if the go-ahead is given for treatment. Other anti-virals: Favipiravir (Toyota Chemical) being trialed in Japan Galidesivir (Biochryst) status unknown Others:

UNMC announced this drug was previously used by them to treat Ebola patients UNMC treated. I have not heard an update since this was first announced but at the time they sounded optimistic about the possibilities with this drug. And look at how fast production could be ginned up.

TexasTowelie

(112,252 posts)
59. Animal experiments show the potential for teratogenic effects on fetuses
Thu Mar 19, 2020, 07:17 AM
Mar 2020

Certainly not recommended for someone who is pregnant or thinking about becoming pregnant.

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