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Related: Editorials & Other Articles, Issue Forums, Alliance Forums, Region ForumsJapanese flu drug 'clearly effective' in treating coronavirus, says China. From The Guardian...
3-18-20
"Medical authorities in China have said a drug used in Japan to treat new strains of influenza appeared to be effective in coronavirus patients, Japanese media said on Wednesday.
Zhang Xinmin, an official at Chinas science and technology ministry, said favipiravir, developed by a subsidiary of Fujifilm, had produced encouraging outcomes in clinical trials in Wuhan and Shenzhen involving 340 patients.
It has a high degree of safety and is clearly effective in treatment, Zhang told reporters on Tuesday.
Patients who were given the medicine in Shenzhen turned negative for the virus after a median of four days after becoming positive, compared with a median of 11 days for those who were not treated with the drug, public broadcaster NHK said."
more at link: https://www.theguardian.com/world/2020/mar/18/japanese-flu-drug-clearly-effective-in-treating-coronavirus-says-china
It's good to see more encouraging treatment news each day...
brewens
(13,598 posts)with a vaccine. Please.
abqtommy
(14,118 posts)Spider Jerusalem
(21,786 posts)lagomorph777
(30,613 posts)This is not a risk-free proposition. But the risk tolerance equation is quite different right now.
certainot
(9,090 posts)and there will be more for us
Alwaysna
(574 posts)certainot
(9,090 posts)C Moon
(12,213 posts)hlthe2b
(102,298 posts)disease. Depending on where they are in that work, it might be expedited under "compassionate" use for trials in COVID-19 by FDA. The issue will be getting supplies ramped up.
Guilded Lilly
(5,591 posts)Response to abqtommy (Original post)
democratisphere This message was self-deleted by its author.
Act_of_Reparation
(9,116 posts)The mechanism is unknown, but it seems similar in its effect to Tamiflu--that is, the drug prevents the virus from replicating.
progressoid
(49,991 posts)What a coincidence. I was just having a discussion with my local cheesemonger about pyrazinecarboxamide derivatives.
Act_of_Reparation
(9,116 posts)Fascinating.
lostnfound
(16,184 posts)So happy to read this. And since its not an American pharmaceutical company, they probably wont start the price at $100,000 per treatment.
videohead5
(2,178 posts)To other pharmaceutical manufacturers.
Silver Gaia
(4,544 posts)Now, they need to step it up, Approve it and make enough.
kentuck
(111,104 posts)Girard442
(6,081 posts)I figured that the doctors would shotgun out existing antivirals, hoping for a lucky hit. Maybe this is it.
lark
(23,121 posts)The CDC (at his direction) will say no and then he will say the experts rejected it, ask them, but of course never make them available.
lagomorph777
(30,613 posts)lark
(23,121 posts)He's the dictator in all but name and no one will stop him. Those that could help (R's) are in on the game and the rest don't have sufficient #'s (YET), which is why they are trying to effect a total transfer of wealth to the rich right now.
lagomorph777
(30,613 posts)The GOP will never recover from this.
catchnrelease
(1,945 posts)Sadly people seem to have very short memories. I remember during Junior Bush's term, the various disasters--911, Iraq/Afghanistan, etc etc. People here were saying that there wouldn't be a republican elected again for decades. We got 8 decent years and now look! Even worse than Bush, how can that possibly be? They are like some virulent weed that no matter what you put on it or do to it, it keeps resurrecting! We need to drive a stake through their wizened hearts and cut their heads off!!
lagomorph777
(30,613 posts)Oh wait, they are already feeding us Roundup.
catchnrelease
(1,945 posts)But remember some republicans, er, weeds become resistant even to Roundup!
bronxiteforever
(9,287 posts)crickets
(25,981 posts)Thank you to all of the medical professionals worldwide who are not only taking care of patients but working hard in the labs to find more tools for fighting this illness.
bluestarone
(16,978 posts)At this time we ALL need some good news to follow!! TY for this thread!
SammyWinstonJack
(44,130 posts)Wounded Bear
(58,670 posts)again, trusting the Chinese on this stuff has been difficult.
SCantiGOP
(13,871 posts)I'll believe it when it is the lead story on the Nightly News
(you know, the fake media that we depend on since everything out of the Administration sounds like an LSD-inspired psychotic breakdown).
Wounded Bear
(58,670 posts)better than much of American media, at least.
SCantiGOP
(13,871 posts)But this story seems like a major breakthrough, so I would like a second opinion.
AtheistCrusader
(33,982 posts)Just.. .for fucking starters, the drug is from Japan. China is simply saying 'hey, this seems to be working'.
I see no reason not to be grateful for this information. They've been through a hell of a thing, and they are finally winning. Please ease up.
FiveGoodMen
(20,018 posts)I don't think it's any more "China hate" to point out that their government isn't always honest than pointing out Trump's flaws is "America hate"
AtheistCrusader
(33,982 posts)It is not surprising to me that a country with a centrally planned economy (approaching mixed-market) behaves the same way about Information, as they do economics.
It is unreasonable to expect them to behave like a western democracy. They are not. Hell, there are times *WE* aren't. Our government lies to us, and the world, all the damn time. Distorts and throttles information, all the damn time.
China has just been through some real shit, and it's not entirely over yet. Please cut them some slack. These are good times to hold out a hand and build bridges, rather than kick them when they're down.
Don't forget there are other crises on the back burner. Remember the climate? Even with economic throttling, that's still a problem.
We need to work together as a species.
intrepidity
(7,307 posts)As the catalytic domain of RdRp is conserved among various types of RNA viruses, that mechanism of action supports a wide spectrum of potential activity. Avigan works against a broad range of influenza virus types as well as West Nile virus, yellow fever, foot-and-mouth disease, and other flaviviruses, arenaviruses, bunyaviruses and alphaviruses, he noted.
https://www.bioworld.com/articles/433290-fujifilm-stock-rises-as-japan-considers-avigan-for-covid-19-treatment
pangaia
(24,324 posts)ABROAD17.03.2020 - 18:35
French virologist: we have medicine against Covid-19
Didier Raoult, director of the Mediterranean Institute for Infections publishes encouraging test results
by @Ansa
Paris - "We know how to heal from Coronavirus": the French virologist Didier Raoult, director of the Mediterranean Institute for infections in Marseille, in the south of France, announces it exclusively to "Les Echos".
Raoult published the results of his clinical trial on the treatment of Coronavirus with chloroquine. Three quarters of the infected patients were no longer carriers of the virus after 6 days of treatment with Plaquenil, one of the commercial names of chloroquine, generally used against malaria: "associated with taking targeted antibiotics against bacterial pneumonia (the azithromycin) - said the infectious disease specialist, whose work is among the most published in the world - has totally healed patients within a week, while 90% of patients who have not taken the drugs are always positive ".
https://www.laregione.ch/estero/estero/1426325/virologo-francese-abbiamo-la-medicina-contro-il-covid-19?fbclid=IwAR3OvKi2prQHDJXrYmn53aEr4Nvj45XzWIQ70o6Zr4bxOS3oFVw7cdsNfgE
AtheistCrusader
(33,982 posts)It's actually pretty weaksauce as antibiotics go. Sounds preventative on the pneumonia side.
pangaia
(24,324 posts)I had a really bad cough for weeks.. started before COVID-19 'showed up' in the USA. I do have a a history of pneumonia once in about 1990 - 1 lung. And since then occasionally bronchitis... usually it goes away on its own or if not I get one or another anti-biotics.. the older 10 day kind.. So last Monday, 9 days ago, I went to my doc, he said bronchitis and gave me Azithromycin, which is the newer 5 day version of the older 10 day ones, but it works in the body for 10 days...... The cough etc is much better but not all gone... I'll see how it is thurs the 10th day !
AtheistCrusader
(33,982 posts)I'm allergic to Amoxicillin so they give me Azithromycin instead. I get seasonal sinus infections. Usually around Thanksgiving.
Couple times I've had to use something stronger, but it usually does the trick.
thesquanderer
(11,990 posts)Of course, it's very significant, but as the article says:
Meaning: The people who would get better anyway (which is most people) get better sooner. That's helpful, but doesn't directly address either lethality or spread. Though it would allow people to end their quarantines sooner.
I think this is more important, but it is still only a limited treatment, since these numbers indicate that 29% of those who experience lung impairment are still not helped by this drug. 62% see these improvements even without the drug (meaning 38% don't); with the drug only 9% don't (the difference between 100% and 91%); so compared to the current situation, the drug is helping the difference between the 38% and the 9%, which is 29%.
Also worth noting:
but if testing becomes easily and widely available, hopefully it is more often caught before symptoms become severe.
I think this is great, I just caution people about thinking a full cure looks to be around the corner based on this info.
AtheistCrusader
(33,982 posts)The longer you have it, the more likely you get secondary shit like pneumonia. So it should indirectly reduce the lethality. (Presuming the initial claims are accurate.
Roland99
(53,342 posts)But a Japanese health ministry source suggested the drug was not as effective in people with more severe symptoms. Weve given Avigan to 70 to 80 people, but it doesnt seem to work that well when the virus has already multiplied, the source told the Mainichi Shimbun.
The same limitations had been identified in studies involving coronavirus patients using a combination of the HIV antiretrovirals lopinavir and ritonavir, the source added.
Maraya1969
(22,484 posts)for antibodies and those stayed.
live love laugh
(13,119 posts)chomping at the bit to contribute to getting this so they can get back to normal.
SunSeeker
(51,574 posts)MyNameGoesHere
(7,638 posts)Has been a racist prick to Asians, we might get it in a decade or so. After this negligent manslaughter he is culpable for, fuck impeachment. Physically dragged from office is the correct remedy.
rockfordfile
(8,704 posts)dewsgirl
(14,961 posts)Grokenstein
(5,725 posts)"Isn't there some way I can stop this from happening?"
McCamy Taylor
(19,240 posts)when you are already on a ventilator. Meaning that only the rich who can get testing on demand will benefit even if it does work, because they rest of us have to be on death's door to get a test.
Maybe for those in quarantine after a known exposure....
Fla Dem
(23,693 posts)While we have a president that cant work with anyone.
Aussie105
(5,405 posts)I'm still waiting for the cheap, do it yourself home test to be developed.
Similar to the pregnancy test, it uses sheep red blood cells agglutinating in the presence of a specific chemical. In the pregnancy test, a hormone, in a COVID-19 test, the virus itself, or an antibody produced in response to the virus.
(I think that is how it works, anyway.)
I'd buy a whole stack of them, test myself morning and night. That way I'd know exactly where I stood with this virus.
Demonaut
(8,919 posts)and they will be valid, no! it's not been tested thoroughly enough, too expensive, rare components, and other delay tactics
DallasNE
(7,403 posts)Feb 29, 2020 · "Remdesivir is currently in Phase III trials in China and at the University of Nebraska Medical Center (UNMC) in Omaha. Gilead has said they could have 100,000 doses ready in 3 days if the go-ahead is given for treatment. Other anti-virals: Favipiravir (Toyota Chemical) being trialed in Japan Galidesivir (Biochryst) status unknown Others:
UNMC announced this drug was previously used by them to treat Ebola patients UNMC treated. I have not heard an update since this was first announced but at the time they sounded optimistic about the possibilities with this drug. And look at how fast production could be ginned up.
TexasTowelie
(112,252 posts)Certainly not recommended for someone who is pregnant or thinking about becoming pregnant.