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Mike 03

(16,616 posts)
Mon Mar 30, 2020, 09:30 AM Mar 2020

How a large viral load could make coronavirus infection worse

UK Daily Mail
UPDATED: 09:20 EDT, 30 March 2020

How the amount of the coronavirus you get infected with could decide whether you suffer mild or severe symptoms

A study on COVID-19 patients in China links high viral load to worse symptoms

Viral load is the amount of a virus inside someone's body during infection

People can try to minimise their initial viral load with strict social distancing

Fewer viruses at the beginning of illness could help the immune system react

As well as reducing the risk of coronavirus spreading social distancing could make people's symptoms milder if they do get the illness, scientists say.

It can do this by reducing a patient's viral load - the number of particles of the virus they are first infected with.

Having a high viral load gives an infection a 'jump start' and raises the risk of a patient's immune system becoming overloaded in its battle against COVID-19.

People can slash their chances of a massive initial infection by staying away from others who might be ill and by sticking strictly to the rules against close personal contact which millions of people around the world are now faced with.

Someone infected indirectly by touching a door handle could ultimately end up with milder symptoms than someone who inhales an infected person's cough, experts say.

And this is because it gives the immune system more time to get a handle on the infection before it gets overwhelmed and symptoms start to show.

'In general with respiratory viruses, the outcome of infection – whether you get severely ill or only get a mild cold – can sometimes be determined by how much virus actually got into your body and started the infection off,' says Professor Wendy Barclay, an infectious diseases expert at Imperial College London.

'It’s all about the size of the armies on each side of the battle, a very large virus army is difficult for our immune system's army to fight off.'

The way viruses make people ill is by multiplying rapidly once inside the body and building up in such large numbers that the body takes weeks to destroy them all.

This process is inevitable once someone has caught an infection, but it is possible for people to first become ill with only a small dose of a virus.

This can, in theory, make it easier for their body's immune system 'army' to cope and to fend off the early infection.

In fact, for coronavirus, it seems likely that a large majority of patients become ill under this circumstance and take an unusually long time to notice they're sick.

Because of this, people appear to be spreading COVID-19 more widely than they would if they had a more serious disease.

Dr Michael Skinner, also from Imperial College, said that if someone starts off with a massive amount of the virus it could overload their immune system.

The virus would get a 'jump start' in such circumstances, he suggested, because it would be able to build up faster before the body had time to respond.


More at link: https://www.dailymail.co.uk/news/article-8166867/How-large-viral-load-make-coronavirus-infection-worse.html





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How a large viral load could make coronavirus infection worse (Original Post) Mike 03 Mar 2020 OP
Interesting. Could explain why so many younger healthcare workers get very bad cases. tanyev Mar 2020 #1
I was wondering about that. Good information! Thanks. Jim__ Mar 2020 #2
So this is the reason for a lot of people's hard on set uponit7771 Mar 2020 #3
Stop snooping through my vibrator drawer. WhiskeyGrinder Mar 2020 #5
This is why doctors and nurses need N95 masks dalton99a Mar 2020 #4

dalton99a

(81,565 posts)
4. This is why doctors and nurses need N95 masks
Mon Mar 30, 2020, 11:04 AM
Mar 2020

More than any other profession, they are being repeatedly exposed at close range, day in and day out


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