General Discussion
Related: Editorials & Other Articles, Issue Forums, Alliance Forums, Region ForumsNYT: What if We Already Have a Coronavirus Vaccine?
Surprising new research in a niche area of immunology suggests that certain live vaccines that have been around for decades could, possibly, protect against the coronavirus. The theory is that these vaccines could make people less likely to experience serious symptoms or even any symptoms if they catch it.
At more than 25 universities and clinical centers around the world, researchers have begun clinical trials, primarily in health care workers, to test whether a live tuberculosis vaccine that has been in use for 99 years called the bacillus Calmette-Guérin, or B.C.G., vaccine, could reduce the risks associated with the coronavirus.
Another small but esteemed group of scientists is raising money to test the potential protective effects of a 60-year-old live polio vaccine called O.P.V.
Its counterintuitive to think that old vaccines created to fight very different pathogens could defend against the coronavirus. The idea is controversial in part because it challenges the dogma about how vaccines work.
https://www.nytimes.com/2020/05/01/opinion/coronavirus-vaccine-innate-immunity.html
Very interesting theory, I had not heard this one before. There's got to be something out there that will get rid of this thing. There has to be.
LisaL
(44,973 posts)And I am supposed to believe it could protect from covid?
Tuberculosis is spread by bacteria. Covid is a virus.
It seems like a really bit stretch.
The Magistrate
(95,247 posts)This old tuberculosis vaccine seems to produce a sort of general tuning up of immune response, that has been observed to affect other pathogens than the one it was produced as a specific for, including some viruses. The how and why of this is beyond my grasp to assess, but the phenomenon was reported respectably. It was described, though, as a long-short for this current contagion. Perhaps something similar has been observed of these other old serums.
wnylib
(21,486 posts)disease that affects the lungs, maybe its possible use for the coronavirus is to prevent the severity of secondary bacterial infections that occur in the lungs as a result of coronavirus infection. That would increase a person's survival chances once they are positive for covid 19.
The Magistrate
(95,247 posts)This thing seems to excite a broad, but non-specific reaction from the immune system, which was early observed to work strongly against tuberculosis bacilli, but also against other bacilli, and some viruses, and even some single-cell parasites. Not an especially effective increase in power, mind, but an observable one. For what my opinion is worth, it does not seem an especially promising line, but there is an air of 'don't just stand there, do something!' abroad in the world, and it is an understandable urge, even if much of what is clutched at turns out to be mere straws.
fishwax
(29,149 posts)Most vaccines are deactivated, so they're injecting dead pathogens which do a good job of training your body to fight that specific infection. Live vaccines use a weakened but living pathogen, and the theory is that they trigger a more general response of your immune system--rather than fighting a specific invader with a specialized force. There are some studies that have suggested various live vaccines can help prevent infections other than what they're targeting, including things like the seasonal flu and (hopefully) covid-19. They don't protect against the non-targeted infections as effectively as a specific vaccine would, and perhaps the effects aren't as long lasting, but if it can slow the rate of transmission until a targeted vaccine can be developed that would be huge.
SharonAnn
(13,776 posts)Red Pest
(288 posts)The idea behind the hypothesis is that live vaccines do two things: 1) activate the adaptive immune response, which involves both B-cells (make antibodies) and T-cells (regulate the immune response and are responsible for cellular immunity) and 2) up-regulate the innate immune response (the more evolutionary ancient immune system). Only vertebrates have the adaptive immune response, while all animals have an innate immune response.
The innate immune response will (among other things) recognize viral RNA and mount a general immune response (no antibodies). It is known that a stimulated innate immune response will help organisms resist infections by a variety of pathogens (viruses, bacteria, and protozoans). Various invertebrates have much more complex innate immune systems than do vertebrates.
It is known that administration of live vaccines such as the Sabin oral polio vaccine (Sabin was the cousin of Salk) and BCG not only protect against polio and tuberculosis, respectively, but also those immunized have reductions in other infectious diseases (for ~1 yr).
Anyway, this could help, but is not a specific vaccine against SARS-CoV-2. It could help by slowing or stopping the initial infection by these non-specific mechanisms. Since both oral polio vaccine (OPV) and BCG are extraordinarily safe, there is little/no harm in running a trial. BCG is one of the most widely used vaccines and is effective. OPV is also very safe except if given to those with no immunity to polio and (at the same time) have a severe immune disorder. OPV was the favored polio vaccine for many years in the US.
Anyway, it is probably worth testing the idea. Then we will know whether it has validity or not.
GreenPartyVoter
(72,378 posts)Pantagruel
(2,580 posts)Sorry, illogical.
Initech
(100,080 posts)rgbecker
(4,831 posts)sort of, you know, cleans the whole system. ....
Liberty Belle
(9,535 posts)and switched to a non-live polio vaccine. I don't think that would be wise to give to large numbers of people, killing some who might never have caught the coronavirus. But the TB vaccine is safer; hambe it will work.
LisaL
(44,973 posts)in preventing TB. So a vaccine that is not highly effective against disease it's supposed to prevent is going to be effective against a completely different disease? I find that very hard to believe.
HarlanPepper
(2,042 posts)And they didnt stay at a Holiday Inn Express last night.
LisaL
(44,973 posts)I say, good luck to them.
jaxexpat
(6,833 posts)willow bark helps headaches (but tastes terrible), some grass does better if mowed, pacifist anteaters are hell on army ants, some mushrooms cause god. Oh, the wanders of nature.
erronis
(15,302 posts)What amazes me is that scientists still don't know how many of these drugs actually work. Getting closer to understanding, however.
Midnightwalk
(3,131 posts)They say that the old live vaccine should be safe for people who have already been vaccinated for polio. Im not a doctor but that makes sense I think. If the current vaccination protects you from polio it should protect you against the weaker old live vaccine.
moonscape
(4,673 posts)can't get any live vaccines, even though I had my polio vaccine.
Dadgummit.
Horse with no Name
(33,956 posts)Invalidates the skin test that is used on healthcare workers annually to evaluate for TB. However, there are newer quantiferon tests that are done that wouldnt interact. Ive read a few good articles on the BCG vaccine. It will be interesting to see how it all plays out.
abqtommy
(14,118 posts)doesn't put money in his pocket...
DENVERPOPS
(8,835 posts)with the Pharmaceutical companies.........proven by the fact that they haven't been researching or developing any new antibiotics in Decades.......
Look at the R-something that the drug company is pushing.......The drug company lost a ton of money they spent developing it for something else. It suffered a huge failure. Now they are trying to hype it for Covid, trying to say it is moderately effective, even though it isn't, to recoup their money and to prosper off their failure......And Trump's owning of the FDA won't allow them to come out and discount their Bullshit....
BTW: How do you know Trump is lying? His lips are moving.......
Midnightwalk
(3,131 posts)Its in the excerpt and also emphasized several times that this is intended to make symptoms less severe, not to protect against infection like we normally think of vaccines.
Well worth reading the details in my opinion.
Jamastiene
(38,187 posts)Look at what Trump and his worshipers are getting away with right now. I cannot help but wonder how they are getting way with it. I mean, a few have caught Covid-19, and a few have died, but it seems like they are getting away with an awful lot of tempting fate.
I wish I understood how finding antibodies for it in someone's system works. Does that mean they had it and beat it or that their body sensed it and started trying to protect against it? I have heard that a lot of people in NY have the antibodies in their body for it by now. Isn't that herd immunity or have they figured out whether you can catch it a second time or not?
I have more questions than answers and there is too much conflicting information out there right now to get answers. Maybe they don't have any definitive answers yet. I'm not sure.
erronis
(15,302 posts)Perhaps that something was to be vaccinated pre-covid_19.
wnylib
(21,486 posts)I mentioned this in a previous post on another thread some weeks ago. It would explain why he does not get it now in spite of his recklessness. Would also explain some of his more bizarre than usual behavior around that time. We know now that the virus was active in China at that time and might have been brought to the US that early.
Did Trump have anyone from his inner circle in China in November who could have brought the virus back? Or did he travel to any place in November where he could have come in contact with an infected person in another country? Is it possible that he spread it at his rallies with hand shaking before he became sick with symptoms? Is that why he is so angry with China and paranoid about it being manufactured in China and escaping into the general population?
Jamastiene
(38,187 posts)Whether or not to believe him, I don't know. I do know that a healthy dose of skepticism is the best bet on a lot of things that are not adding up.
Jamastiene
(38,187 posts)Based on what we know already, RE: Trump's actions and inaction in some cases as well, having a healthy skepticism is a smart idea. How are all of those people at rallies not getting sick in much larger numbers? Why are areas known to be "blue" areas in blue states getting sick more than in other places? Why did Pence not wear a mask the other day, this late into the pandemic.
I think we need answers and a healthy amount of skepticism is fair play.
wnylib
(21,486 posts)I think the answer is perhaps not too complicated. Most of the blue states have fairly large, dense populations that allow a few infected people to spread the virus exponentially. Cities that have a lot of tourists, business travelers, and large, busy airports are more vulnerable than other areas to importing the virus and spreading it quickly. Add to that the reliance on public transportation in large urban areas, numerous apartment buildings vs. individual homes, cultural events and restaurants for being in close proximity, and it's not too surprising that they have high rates of infection.
That said, remember the implued threat when North Korea said it had a christmas gift for the US last December?
On the other hand, there is also the fact that the PNAC document, New American Century, stated, among other things, the intent to create bio weapons that could target specific ethnicities. How would they test it? Release it into the world and follow the outbreaks?
These are just questions, not statements of fact. Just something to consider looking into. Might be nothing there and no connection.
LisaL
(44,973 posts)Your idea is that they have a vaccine but are hiding it-for what purpose?
Economy is tanking. And chances of reelection are tanking with the economy.
Jamastiene
(38,187 posts)would be two major reasons that have been used throughout time by various governments.
It's not a serious theory, that they already have a vaccine, but they certainly are handling this the opposite way you would think they would handle it if they wanted to save lives. Why did $400 million dollars get cut from WHO and given to Franklin Graham and other religious groups who said the whole thing was a hoax in the first place. Why were repeated warnings ignored? Why were so many things Obama set up to handle a pandemic stripped of funding and/or dismantled despite those warnings?
I'm not saying they definitely already have a vaccine, but there is information the government (any government, including ours) knows that they don't share with the rest of us. That is for all things that happen. And you can bet they know more than they are letting us know about just about everything, including this.
Some possible reasons would be population control and political control. My bet would be on political control. Look which areas are the hardest hit and look who is out doing as they damn well please while complaining their rights to do as they damn well please have been taken away. There is a such thing as taking advantage of a serious situation. If you don't think Republicans would do that, you haven't been paying attention.
It would not be the first time population and/or political control has been practiced by governments. It would not be the first time a political party has used something that is currently happening for their own advantage. Everyone is so sure Democrats are so safe when the election in November comes. I'm not so sure and I do not trust Republicans not to use insider information to their advantage. Some already have and it has been proven and reported on. (insider trading by Burr and others)
So, while they may not have a de facto vaccine yet, they know things the rest of us do not know because they keep certain things classified. All you need to do is pay attention to see that they are doing things the opposite of what you would think if they wanted to keep people safe. Democratic governors have to kiss Trump's ass just right to get what they need to fight this pandemic. The Republicans are already using it to their advantage over the rest of us. The Republicans are not following any social distancing guidelines and for the most part are getting away with it. Considering how many of them are out doing everything from blocking ambulances to packing themselves in tight areas to protest various governors, there should be way more of an outbreak with them. There just hasn't been. Explain that.
smirkymonkey
(63,221 posts)face masks? Because they have already been vaccinated? I'm just spitballing here.
Jamastiene
(38,187 posts)who may be most affected and most vulnerable to getting it.
I cannot help but notice that all of a sudden they are all over the place about who is most vulnerable to getting it, whether or not someone can get it twice, and a host of other information that they usually have by now on any given outbreak.
I also cannot help but notice how even Pence thumbed his nose at wearing a mask too. Something about all of that just does not add up.
It would not be the first time governments know more than they are telling and use that kind of classified info for their own political or financial or other motives.
Buns_of_Fire
(17,181 posts)With the proviso, as always: First, do no harm.
bucolic_frolic
(43,178 posts)DallasNE
(7,403 posts)One of the clinical trials on a possible vaccine used monkeys in a control group and then exposed them to the CV-19 virus. Could they do the same thing with these vaccines? That shouldn't take long to conduct.
Initech
(100,080 posts)I think it's based off that very premise. And even both Dr. Gilbert and Dr. Fauci are confident that we could have 300 million doses in January. Fingers crossed!
mainer
(12,022 posts)If partial immunity to TB (through BCG vaccine) works against Covid infections, you would think that those who've had TB and were treated for it would be naturally immune.
JCMach1
(27,559 posts)One reason it may not work with adults vs. Covid-19.
So adult TB may not be effective
LisaL
(44,973 posts)Having TB doesn't boost immune system.
GeoWilliam750
(2,522 posts)Have been hit much less hard than those without.
https://www.japantimes.co.jp/news/2020/04/09/world/science-health-world/fewer-coronavirus-deaths-seen-countries-mandate-tuberculosis-vaccine/#.XqymWsgzaUk
https://en.wikipedia.org/wiki/BCG_vaccine
Tokyo, with only slightly less population density than NYC, has been only modestly impacted three months into the pandemic.
JCMach1
(27,559 posts)Vs. say most of Europe, USA...
I feel somewhat lucky my wife and son have BCG.
There is one kink in this though. BCG is given soon after birth for the immune response. One of the reasons they need to test vs. Covid-19 if you give it to an adult.
LisaL
(44,973 posts)And their covid rate is skyrocketing.
JCMach1
(27,559 posts)Interesting, check USA, Europe and Ecuador in South America... Ecuador has been the hardest hit country in South America.
LeftInTX
(25,370 posts)Didn't know where to even look for stats!
Thekaspervote
(32,774 posts)roamer65
(36,745 posts)I believe the Recombivax vaccine for hepatitis B is such a vaccine.
kimbutgar
(21,160 posts)He is the one who invented it!!! And they need to re elect him in November because he is such a stable genius.
Wait for it!
LiberalLovinLug
(14,174 posts)People wonder why Trump is seemingly making an ass out of himself for throwing around experimental and frankly dangerous magic cures. Different ones all the time. Whatever he reads on his QAnon conspiracy sites.
But I think he, or his smarter campaign team, is counting on something like this. If Trump keeps spewing out every crazy remedy before it is properly tested, eventually, I'd say even hopefully, someone will get it right. And during the rigorous testing phase, he will, like all the others, be bleating how people should use this NOW, untested. So when, eventually, it is approved, he will go to the cameras and say "See? what did I say? But the Democrats, and the MSM, who want to tank the economy for political reasons, didn't allow it sooner. They said I was crazy. And now thousands more dead because of their foot dragging"
And yes, WE will know what he is up to. and understand that eventually anyone WILL guess a number between 1 and 10 with enough tries. But he's playing of course not to us, but to his "uneducated" cult who have developed an uncanny ability to completely forget about any past behaviour or statements by their Dear Leader. And if they are reminded of it, it is now "fake news" retroactively.
ARPad95
(1,671 posts)"Virus Killer: The Promising New Superprotein That Could Save Millions of Lives."
Breakthrough
Scientists combined elements of two proteins to create DRACO, a superprotein with broad-spectrum antiviral capabilities.
DRACO the ultimate virus killer?
Scientists have long dreamed of finding a universal antiviral drug - a dream that may soon be within reach, thanks to a newly created superprotein that uses a cell's own suicide mechanism against an invading virus. Have we finally found a way to stop viral infections before they even start?
A universal cure for viruses may be on the horizon
Experiments have shown that DRACO is remarkably effective against viruses that commonly infect humans, but it will likely take at least 10 years for the treatment to hit the market. But when it does, it may fight an array of viral diseases, from the flu to AIDS.
Today (2012): Scientists have engineered the DRACO superprotein, which has proved harmless to healthy, laboratory-grown human and animal cells, but deadly to cells infected by 15 different viruses.
2013: Scientists develop new versions of DRACO with improved tracking and suicide mechanisms that can eliminate more viruses more effectively.
2014: Scientists discover how DRACO spreads in the bodies of mice and how long the superprotein remains active.
2016: Large-scale experiments show that DRACO is effective against viral infection of animals living under natural conditions.
2017: Initial clinical tests demonstrate that DRACO is harmless to healthy humans.
2020: Large-scale clinical trials determine that DRACO can combat a series of viral infections in humans living under natural conditions.
2022: Health authorities approve DRACO, which subsequently goes on the market.
It appears the funding fell through as of December 2015.
[link:https://www.change.org/p/world-health-organization-bring-back-draco-antiviral-against-coronavirus-disease-covid-19|]
muriel_volestrangler
(101,321 posts)Twitter thread here:
Link to tweet
"BUT, I am surprised to see how uncritical the media has been about these ecological studies.
I am also worried that policy makers in some countries have been quick to pounce on this and might not do what they could be doing (e.g. ramp up testing, contact tracing, PPE, hygiene).
I am aware that randomized trials on BCG and COVID are starting and welcome them.
Until then, we need to very cautious about getting too excited about ecological studies for several reasons:"
There is experimental evidence from both animal and human studies that the BCG vaccine has non-specific effects on the immune system. These effects have not been well characterized and their clinical relevance is unknown.2,3
...
The review yielded three preprints (manuscripts posted online before peer-review), in which the authors compared the incidence of COVID-19 cases in countries where the BCG vaccine is used with countries where it is not used and observed that countries that routinely used the vaccine in neonates had less reported cases of COVID-19 to date. Such ecological studies are prone to significant bias from many confounders, including differences in national demographics and disease burden, testing rates for COVID-19 virus infections, and the stage of the pandemic in each country.
https://www.who.int/news-room/commentaries/detail/bacille-calmette-gu%C3%A9rin-%28bcg%29-vaccination-and-covid-19
canetoad
(17,168 posts)Early in pandemic, as a 'cure'. Sorry no links, but I remember a vaccine that was alread y human-tested.
I would hope the research has progressed and this vaccine is proving effective.