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Related: Editorials & Other Articles, Issue Forums, Alliance Forums, Region ForumsOne in three young adults may face severe COVID-19, study shows
Science Daily
Smoking habits trump asthma, obesity in risk factors for otherwise healthy population
Date:July 13, 2020
Source:University of California - San Francisco
As the number of young adults infected with the coronavirus surges throughout the nation, a new study indicates that youth may not shield people from serious disease...a new study by researchers at UCSF Benioff Children's Hospital...looked at data drawn from a nationally representative sample of approximately 8,400 men and women ages 18 to 25 and concluded that overall "medical vulnerability" was 33 percent for males and 30 percent for females. The impact of smoking surpassed other less common risks, the UCSF researchers reported in their study, which publishes in the Journal of Adolescent Health on July 13, 2020.
The researchers, led by first author Sally Adams, PhD, of the UCSF Division of Adolescent and Young Adult Medicine, determined vulnerability by referencing indicators identified by the CDC. These included heart conditions, diabetes, current asthma, immune conditions (such as lupus, gout, rheumatoid arthritis), liver conditions, obesity and smoking within the previous 30 days. Additionally, the researchers added e-cigarettes to tobacco and cigar use, which the CDC had included, stating that all three were associated with adverse effects on respiratory and immune function.
Smoking Linked to Progression of COVID-19
"Recent evidence indicates that smoking is associated with a higher likelihood of COVID-19 progression, including increased illness severity, ICU admission or death," said Adams. "Smoking may have significant effects in young adults, who typically have low rates for most chronic diseases."
... The risk of being medically vulnerable to severe disease is halved when smokers are removed from the sample," said senior author Charles Irwin Jr., MD, of the UCSF Division of Adolescent and Young Adult Medicine. "Efforts to reduce smoking and e-cigarette use among young adults would likely lower their vulnerability to severe disease."
https://www.sciencedaily.com/releases/2020/07/200713104344.htm
dalton99a
(81,570 posts)denem
(11,045 posts)According to Haynor and colleagues, recent studies have shown that smokers are significantly under-represented among hospitalized COVID-19 patients in China, France, Italy, Germany, the UK, the USA, Israel, Iran, South Korea, Kuwait, Mexico, Spain, and Switzerland.
The apparent substantial under-representation of smokers among COVID-19 inpatients consistently across thirteen countries is remarkable, says the team. This is surprising as smoking is generally associated with greatly exacerbating respiratory infections.
Suggested mechanisms that may confer a protective effect of smoking include altered host cell expression of angiotensin-converting enzyme 2 (ACE2, the receptor the virus uses to infects cells); the anti-inflammatory activity of nicotine; the antiviral effect of nitric oxide; the effects of smoking on the immune system and vapor heat-related stimulation of immunity in the respiratory tract.
https://www.news-medical.net/news/20200615/An-inverse-relationship-between-smoking-and-COVID-19.aspx
Baclava
(12,047 posts)denem
(11,045 posts)Baclava
(12,047 posts)Dem2
(8,168 posts)Still, I wouldn't imagine that, once infected, being a smoker is then a positive...
denem
(11,045 posts)COVID-19 is not a respiratory disease. It attacks right across the body.
Dem2
(8,168 posts)Was worried that my mom was at higher risk for a long time due to her asthma, was happy to see that disproved in the NY numbers.
bronxiteforever
(9,287 posts)recent studies show a complicated connection with asthma.
These are discussed here.
Does asthma increase Covid-19 risk? Emerging research suggests a complicated connection
By JULIET ISSELBACHER JULY 2, 2020
https://www.statnews.com/2020/07/02/asthma-covid19-connection-research/
Not all asthmatics are the same, said Sharon Chinthrajah, an allergist and researcher at Stanfords Sean N. Parker Center for Allergy and Asthma Research.
Theres evidence to suggest that breaking the data down by asthma subtype could reveal different risk levels. Another recent study, this one conducted by public health researchers at Harvard, analyzed two asthma subtypes allergic asthma and non-allergic asthma as separate risk factors. The two disorders induce similar symptoms, but are set off by different triggers: allergic asthma flares up with exposure to allergens like pollen and mold, while non-allergic asthma is exacerbated by exercise, stress, cold weather, and more.
The population-based study, published as a pre-proof paper last month, analyzed medical records from 492,768 people registered in the U.K. Biobank and found that non-allergic asthma significantly heightened the likelihood of severe Covid-19, while allergic asthma did not.
One study is here
https://www.jacionline.org/article/S0091-6749(20)30806-X/pdf
In conclusion, the large population-based cohort study demon- strated that adults with asthma had a higher risk of severe COVID- 19, which was driven by the increased risk in patients with nonallergic asthma. In contrast, the risk of severe COVID-19 was not significantly elevated in patients with allergic asthma. In addition, the study demonstrated the absence of association between the existing genetic polygenic score for asthma and COVID-19. These observations should help clinicians optimize risk- stratification of patients with asthma (and its phenotypes). Further- more, our inferences should advance the research into delineating the complex interrelations between SARS-CoV-2 infection, airway inflammation, and outcomes in patients with asthma.
Response to denem (Reply #2)
bronxiteforever This message was self-deleted by its author.