Genetically modified monkeys created with cut-and-paste DNA

Researchers have created genetically modified monkeys with a revolutionary new procedure that enables scientists to cut and paste DNA in living organisms.

The macaques are the first primates to have their genetic makeup altered with the powerful technology which many scientists believe will lead to a new era of genetic medicine.

The feat was applauded by some researchers who said it would help them to recreate devastating human diseases in monkeys, such as Alzheimer's and Parkinson's. The ability to alter DNA with such precision is already being investigated as a way to make people resistant to HIV.

But the breakthrough is controversial, with groups opposed to animal testing warning that it could drive a rise in the use of monkeys in research. One critic said that genetic engineering gave researchers "almost limitless power to create sick animals".

The work was carried out in a lab in China, where scientists said they had used a genome editing procedure, called Crispr/Cas9, to manipulate two genes in fertilised monkey eggs before transferring them to surrogate mothers.

http://www.theguardian.com/science/2014/jan/30/genetically-modified-monkeys-cut-and-paste-dna-alzheimers-parkinsons