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Related: Editorials & Other Articles, Issue Forums, Alliance Forums, Region Forumsgreat news !! treatment found that tricks body into killing cancer tumor.
http://nypost.com/2013/03/27/one-drug-to-rule-them-all-researchers-find-treatment-that-kills-every-kind-of-cancer-tumor/Researchers might have found the Holy Grail in the war against cancer, a miracle drug that has killed every kind of cancer tumor it has come in contact with.
The drug works by blocking a protein called CD47 that is essentially a do not eat signal to the bodys immune system, according to Science Magazine.
This protein is produced in healthy blood cells but researchers at Stanford University found that cancer cells produced an inordinate amount of the protein thus tricking the immune system into not destroying the harmful cells.
With this observation in mind, the researchers built an antibody that blocked cancers CD47 so that the bodys immune system attacked the dangerous cells.
So far, researchers have used the antibody in mice with human breast, ovary, colon, bladder, brain, liver and prostate tumors transplanted into them. In each of the cases the antibody forced the mices immune system to kill the cancer cells.
We showed that even after the tumor has taken hold, the antibody can either cure the tumor or slow its growth and prevent metastasis, said biologist Irving Weissman of the Stanford University School of Medicine in Palo Alto, California.
more at the link.
Nay
(12,051 posts)started, and what the results are? As a breast cancer survivor, I'd love to have this antibody available if my cancer returns.
littlewolf
(3,813 posts)no word on human tests .... sorry ...
bowens43
(16,064 posts)"For the last year, many people have been working to make clinical trials possible. We are now hopeful that the first human clinical trials of anti-CD47 antibody will take place at Stanford in mid-2014, if all goes well. Clinical trials may also be done in the United Kingdom."
littlewolf
(3,813 posts)Nay
(12,051 posts)spinbaby
(15,090 posts)...that human cells transplanted into mice die.
GeorgeGist
(25,321 posts)read the science before you make foolish statements.
Demo_Chris
(6,234 posts)WinstonSmith4740
(3,056 posts)Bittersweet for me (my husband passed almost 4 years ago), but a wonderful breakthrough. I really hope the clinical trials go well. But I also think this shows there's nothing like our own immune system when it comes to fighting this stuff. Right now, cancer treatment (at least the type that insurance pays for) is restricted to poisoning (chemo), burning (radiation) or cutting (surgery). Mike had all three and it was brutal. Bringing our own natural defenses into play can only make treatment better.
BrotherIvan
(9,126 posts)I lost my mother last year. She died from the treatment, not the cancer as hers was a very slow developing kind. My condolences to you as I know how hard it is to go through all of the treatments, and then you lose your loved one. It's hell on both of you.
Those researchers who have been willing to think out of the box of slash/burn/poison have been doing some great work. Harnessing the immune system is THE answer because in healthy people, it is killing cancer cells every day. The fact that our current, over 100 year-old paradigm, kills off the immune system is just madness. It will be a day for celebration once this treatment is available. If these trials don't work, they will find something else because they are at least looking in the right spot.
WinstonSmith4740
(3,056 posts)We both know how tough going through that was. Unfortunately, Mike's was caused by a bad gene that kept creating cancer, BUT I totally agree with you on the body constantly knocking this stuff down. Most people who have the defective gene develop cancer in their 30's. Mike was 66. He also had the most amazing immune system I've ever seen, so there's no doubt in my mind he kept beating it back throughout his life. But as we age, things start to break down, and his body couldn't fight back as effectively as it could in the past. So, yeah, the treatment that destroyed what was left of his immune system never made a lot of sense.
So hopefully, more and more research will pursue the more natural, body-based approach. A real victory will also be when it'll be an option that insurance will finally accept and pay for, as opposed to considering it "alternative" treatment, and not covered.
Logical
(22,457 posts)ljm2002
(10,751 posts)...and am very glad to have seen it this morning. Given that clinical trials will be starting soon, it seems to be quite relevant to the present day.
Now if this story had been posted in Latest Breaking News, then you'd have a point.
IADEMO2004
(5,554 posts)and hope it is as good as it sounds.
CFLDem
(2,083 posts)This is wonderful news!
Laelth
(32,017 posts)-Laelth
krawhitham
(4,644 posts)Researchers and staff at Stanford are continuing to work hard preparing the groundwork for the clinical trials of our anti-CD47 antibody as a cancer therapy. We are anticipating the start of clinical trials sometime in the first half of this year, though unforeseen delays may yet slow that progress. As we get closer to the start of the clinical trials, we will be posting information about eligibility for the trials and how to apply.
There has been a huge amount of interest in these trials from patients and their families and friends. However, we feel compelled to emphasize that, as is typical of FDA phase I clinical trials, the first tests of this therapy will be very small safety trials involving only a very few patients. Unfortunately, this means only a tiny fraction of those interested will be admitted to the first phase I clinical trials. Accordingly, we are urging patients to continue exploring existing treatments and other clinical trials.
http://stemcell.stanford.edu/CD47/