In 1986, 7-Eleven stopped selling Playboy and Penthouse magazines after a two-year boycott by the AFA.[37] In 1989 the AFA boycotted WaldenBooks in an attempt to persuade the company to stop selling those same magazines. As a result, WaldenBooks launched an advertisement campaign against censorship, asserting First Amendment rights. WaldenBooks, American Booksellers Association, the Council for Periodical Distributors Association, the International Periodical Distributors Association, and Duval Bibb Services launched a lawsuit against the AFA in October 1989, under the Federal Racketeer Influenced and Corrupt Organizations Act (RICO) and the Florida State RICO Acts, which protect an organization's right to conduct business without harassment or threats.[38] The case was settled by the parties without a court ruling.

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In 2003, the AFA, with the American Decency Association, Focus on the Family, and Citizens for Community Values, lobbied and boycotted Abercrombie & Fitch, calling on "A&F to stop using blatant pornography in its quarterly catalog."[47] In December 2003, the company "recalled the holiday catalog from all its stores, saying it needed the space on the counter for a new perfume" and stated it would stop printing catalogs and start a new campaign.[48]

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In Spring 2005 the AFA launched a boycott of Ford for advertising in gay magazines, donating to gay rights organizations, and sponsoring gay pride celebrations.[43][50][51] After meeting with representatives of the group, Ford announced it was curtailing ads in a number of major gay-themed publications, due not by cultural but by "cost-cutting" factors. That statement was contradicted by the AFA, which claimed it had a "good faith agreement" that Ford would cease such ads. Soon afterwards, as a result of a strong outcry from the gay community, Ford backtracked and announced it would continue ads in gay publications, in response to which the AFA denounced Ford for "violating" the agreement, and renewed threats of a boycott.[52] The boycott ended in March 2008.[53]

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The AFA expresses public concern over what it refers to as the "homosexual agenda". They state that the Bible "declares that homosexuality is unnatural and sinful" and that they have "sponsored several events reaching out to homosexuals and letting them know there is love and healing at the Cross of Christ."[81]