Ultimately the only solution is a single-payer / Medicare-for-all system where drug companies are regulated stricter than utility companies. If they find that too restrictive, R&D can be relegated solely to public Universities and manufacture to the lowest bidder.

Drug companies sole desire is to make a profit. Humanity plays no role. Why then should anyone believe they will perform any better than a University? Why not pay professors a high salary to develop products based solely on science without the worry of advertising cost, exploitative executives, and shareholders. Single-payer give Americans the power to demand.