Autism shown to have no link to measles vaccine
Source: MSNBC
"Controversy seems to follow autism like the tail on a kite," Dr. Bryan King, a researcher at Seattle Children's Autism Center and the University of Washington, wrote in an editorial published Tuesday in the Journal of the American Medical Association.
One that should be put to bed is any connection between autism spectrum disorder and the measles vaccine, according to a separate study published Tuesday in JAMA. It's the latest of at least a dozen studies, according to King, to show no connection.
Researchers examined data on more than 95,000 kids with older siblings, including almost 2,000 with an older sibling with autism spectrum disorder (ASD), to assess risk among those already at higher likelihood of developing autism because of a family connection.
Read MoreWhere we stand on autism
They found "no harmful association between MMR vaccine receipt and ASD even among children already at higher risk for ASD," wrote the study authors, led by Anjali Jain of the Lewin Group, a health-care consulting firm
Continued at Link
Read more: http://www.cnbc.com/id/102605133
murielm99
(30,741 posts)didn't we know this already?
Dr Hobbitstein
(6,568 posts)But it keeps getting restudied due to anti-vaxxer panic. Not that that seems to do much good.
Moonwalk
(2,322 posts)...that people actually blamed "cold" mothers for autistic kids (!) That was back in the late '50's early '60's pop psycology. Poor people (usually of color) weren't taking their autistic kids in to be diagnoised. But newly middle-class white folk were, and so the psychologists began to think that autism was a white-kids-of-middle-class-parents phenonemon. And that the mothers must be the problem. They weren't nuturing enough or whatever.
Same issue here for the anti-vaxers. Find a quick cause for it, and, therefore, not only someone to blame, but a "cure" for it as well. I imagine in 5-10 years this vaccine connection will be looked at the same way we look at the "cold mom's" assertion today. Ridiculous and how could any one have believed that?
Thing is, from what we currently know, autism is not caused by anything so direct as a cold mother or vaccine. Beyond straight up genetic factors (like a baby born with this or that color of eye or left-handed rather than right), baby's time in the womb may also be behind autism. The womb is not a serene bubble where the baby can develop on DNA alone. Chemical changes come and go and affect and alter development.
And that's not to blame the moms either. This isn't about mom (or dad) drinking or taking drugs. Dad could have been healthy, and mom could have eaten right, abstained from anything that might have hurt her child while pregnant, etc. Sometimes, like the kid being left-handed, these things turn up. And it's not through a single, particular cause that could have been avoided. It's just how the chemistry and genetics lined up. But that is aweful hard for parents to accept. That this was the luck of their genetic/chemical draw, not that someone "did this" to their child.
Not exactly.
No offense, but what you wrote sounds like a lot of stuff I read about Autism written by well meaning people who don't really have a clue about Autism.
Most of the real issue here is with parents that are totally freaked out for their kids.
If they're anti vax, they mistakenly see a correlation between the shots and the onset of an Autism diagnosis that happens around 18 months of age.
Having your kid get diagnosed with Autism is like being told your kid is going to die.
Parents are looking for any kind of information on how to help their kids. Anything new that can help them communicate with their kid.
Unfortunately, there's a lot of snake oil salesmen offering bogus science, cures, and odd diets to profit off of scared parents that just got an Autism diagnosis.
That's where the anti vax crowd gets started by buying into it.
Parents of kids that have Autism are worried more about their kid's health and well being than any woe is me BS.
There's nothing quick about Autism and there's no cure for any of it.
It's a lot of work.
proverbialwisdom
(4,959 posts)Dr Hobbitstein
(6,568 posts)I understand autism. And my kid's health.
But that is beside the point.
This article is about the fact that there is NO link between vaccines and autism. It has nothing to do with "curing" autism.
Throckmorton
(3,579 posts)Really, like getting a fatal diagnosis for you child.
I have had it happen twice, and I never saw it that way.
A lot of work, you bet, but so are a lot of conditions you can be dealt when having a child.
Search for a cause of my child's autism, well that is just a great big waste of my time.
Search for the guilty, no point really, what will that change, they are here to stay?
Cure, not ever going to happen. Besides, how do you cure something that isn't a disease?
Response to doug1105 (Reply #24)
Post removed
alp227
(32,025 posts)http://conwebwatch.tripod.com/stories/2014/mrcattkisson2.html
Pushes questionable anti-Obama storylines, writes now for the Heritage Foundation.
SwankyXomb
(2,030 posts)anti-vaxxer band of expletives will be along shortly to drip their woo-froth all over this thread..
LynneSin
(95,337 posts)And she does have an esteemed degree from the Playboy Centerfold Instititute
Moonwalk
(2,322 posts)LynneSin
(95,337 posts)I mean she really is ground zero with this whole 'Don't vaccinate your kid it causes autism' misinformation because she does have an child with autism. I think she used google, found that discredited research paper and grasped straws assuming it was the vaccines that caused her child to becoming autistic. But what's scary is that people actually started listening to Jenna McCarthy, a woman with absolutely no medical background other than the ability to google, instead of their doctors and this whole Anti-vax stuff exploded.
Response to LynneSin (Reply #6)
Name removed Message auto-removed
Moonwalk
(2,322 posts)..saying that her kid was fine. She took him to be vaccinated. And right after he got the shot she saw "the light go out of his eyes..." i.e. he became autistic in that very moment.
I've no doubt this is a total fabrication--one, however, that's she's convinced herself is true, with terrible consequences for us all. However and whenever her kid's autism became apparent to her (there is a kind that comes on "suddenly"--toddler seems to be fine, then one day they're not), that's her story and as she told it on Oprah it had way too much visablity.
In short, I blame Oprah and all the other talk shows that gave her a form to spread this story as much as I blame her and they should all be sued. No talk or news show should be allowed to disseminate misinformation like that.
AlbertCat
(17,505 posts)This may very well have happened. But it doesn't mean the shot is responsible. It coulda been that peanut butter sandwich she made for him an hour before... Or maybe the faulty genes she contributed to his genome upon conception.
Or none of those things....
until there is some establishment of cause and effect beyond "this happened right before....."
Moonwalk
(2,322 posts)...the sandwich was either. Whatever causes autism (and it's unlikely one thing) it's there from sometime prior to baby's birth.
There are tests they're able to do now that can find out if an infant is likely to be autistic. This is huge, by the way, because the earlier one intervenes the better. The autism can't be "cured" but the autistic can gain ground and become less severely so.
The whole anti-vax movement has done more than cause issues with immunization, it's also undermined real research into autism, both it's causes and what can be done to alleviate it. This includes the diversion of funds from serious research into junk, anti-vax causes.
doug1105
(5 posts)Currently, there is no pre-natal test for Autism. There's research, but nothing solid yet.
Moonwalk
(2,322 posts)...but almost all tests are still about observing "signs" rather than chemical tests. But, at least, with such a lot of focus on autism, there have been leaps and bounds in recognizing it and working with it.
proverbialwisdom
(4,959 posts)Editorial | April 21, 2015
Promising Forecast for Autism Spectrum Disorders
Bryan H. King, MD, MBA1,2
[-] Author Affiliations
1Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle
2Seattle Childrens Hospital, Seattle, Washington
JAMA. 2015;313(15):1518-1519. doi:10.1001/jama.2015.2628.
Frankly, psychiatry is not the best field to provide answers to questions about autism. That's the old paradigm.
Haven't seen any analyses of this yet. Developing...
Original Investigation
Autism Occurrence by MMR Vaccine Status Among US Children With Older Siblings With and Without Autism
Anjali Jain, MD1; Jaclyn Marshall, MS1; Ami Buikema, MPH2; Tim Bancroft, PhD2; Jonathan P. Kelly, MPP1; Craig J. Newschaffer, PhD3
[-] Author Affiliations
1The Lewin Group, Falls Church, Virginia
2Optum, Eden Prairie, Minnesota
3A. J. Drexel Autism Institute, Drexel University, Philadelphia, Pennsylvania
JAMA. 2015;313(15):1534-1540. doi:10.1001/jama.2015.3077.
Other links in the OP here:
http://www.cnbc.com/id/102395826
4/4/15
Interview with Dr Scott Gottlieb, American Enterprise Institute resident fellow
VIDEO- Case closed on vaccine-autism debate
SPIN.
tammywammy
(26,582 posts)proverbialwisdom
(4,959 posts)Last edited Tue Apr 21, 2015, 10:53 PM - Edit history (1)
REPOST: http://www.democraticunderground.com/10141070770#post37
Open Journal of Pediatrics, 2012, 2, 228-235
OJPed http://dx.doi.org/10.4236/ojped.2012.23036
Published Online September 2012 http://www.SciRP.org/journal/ojped/
Vaccination practices among physicians and their children
Michael Martin1, Vahe Badalyan2
1Department of Pediatrics, Inova Fairfax Hospital for Children, Falls Church, USA
2Department of Gastroenterology, Childrens National Medical Center, Washington DC, USA
Received 1 May 2012; revised 3 July 2012; accepted 30 July 2012
ABSTRACT
The purpose of this study was to identify vaccination patterns of both general pediatricians and subspecialists with regards to their own children and projected progeny. A 14 question survey was sent randomly to 1000 members of the Academy of Pediatrics in 2009. Two categories of questions included 1) how physicians with children vaccinated them in the past, and 2) how all respondents would vaccinate a child in 2009. A comparison was made between the answers of general and specialty pediatricians. 582 valid questionnaires were received (58.2% response rate) of which 431 were general pediatricians and 151 sub-specialists. No statistical difference was found between general and specialty pediatricians on how they vaccinated their children up until 2009 (95% vs 93%). When asked about vaccinating a future child, a significant proportion of respondents would deviate from CDC guidelines, specialists more than general pediatricians (21% vs 9%). Generalists were more likely to give a future child Hepatitis A (OR: 3.6; 95% CI 1.3 - 10.4), Rotavirus (OR: 2.2; 95% CI 1.1 - 4.4), Meningococcal (OR: 9.9; 95% CI 3.3 - 29.9), and influenza (OR: 5.4; 95% CI 1.1 - 26.7) vaccines. Specialists were more likely to postpone MMR vaccination (OR: 4.4 95% CI 2.3 - 8.6). Safety was listed by both groups as the most common reason for altering the recommended immunization schedule. Until 2009, general pediatricians and pediatric specialists have largely adhered to ACIP recommendations, but due to vaccine safety and other concerns, both groups, albeit a higher percentage of specialists, reported greater numbers willing to diverge from these recommendations.
tammywammy
(26,582 posts)Cal Carpenter
(4,959 posts)"In this large sample of privately insured children with older siblings, receipt of the MMR vaccine was not associated with increased risk of ASD, regardless of whether older siblings had ASD. These findings indicate no harmful association between MMR vaccine receipt and ASD even among children already at higher risk for ASD."
Are you trying to imply otherwise? What exactly is 'developing...'? I'm honestly never sure what point you are trying to make on these threads. But if you think there is a causal relation between MMR vaccines and ASD, you may want to delete that link from your post because it contradicts your message.
geek tragedy
(68,868 posts)proverbialwisdom
(4,959 posts)Wild world we live in: http://e-patients.net/archives/2012/03/former-nejm-editors-on-the-corruption-of-american-medicine-ny-times.html
Study design is critical. Was timing a variable in the new JAMA study, as here: http://www.democraticunderground.com/101672031
Dr. Mumper (published, 2013); Dr. Thomas (unpublished, 2015)
This isn't about what I think, incidentally. At the moment, however, I decline further discussion. Guess why.
NickB79
(19,243 posts)You don't think JAMA's peer review is sufficient for that?
What do you propose in addition?
And you linked to another DU post you made, using the quack site AgeofAutism as a source?
proverbialwisdom
(4,959 posts)Funny, same general field.
Brief Report | October 1, 2003
Association Between Thimerosal-Containing Vaccine and Autism
Anders Hviid, MSc; Michael Stellfeld, MD; Jan Wohlfahrt, MSc; Mads Melbye, MD, PhD
[-] Author Affiliations
Author Affiliations: Danish Epidemiology Science Centre, Department of Epidemiology Research (Messrs Hviid, Wohlfahrt, and Dr Melbye) and Medical Department (Dr Stellfeld), Statens Serum Institut, Copenhagen, Denmark.
JAMA. 2003;290(13):1763-1766. doi:10.1001/jama.290.13.1763.
CRITIQUES:
http://jama.jamanetwork.com/article.aspx?articleid=197969
https://books.google.com/books?id=-UZgBgAAQBAJ
SEARCH INSIDE: JAMA hviid
READ 1) flawed methodologies and 2) significant COI issues as published in other cited peer-reviewed sourcesin Thimerosal: Let the Science Speak: Chapter 7 (p 76) - "Findings of Epidemiological Studies"
http://www.fourteenstudies.org/HG_8_details.html
http://www.fourteenstudies.org/ranked.html
http://www.putchildrenfirst.org/media/5.18.pdf
RELATED:https://localtvkstu.files.wordpress.com/2015/04/robert-kennedy-vaccine-response. jpg (drop the space before jpg to view)
Engage the primary sources you ridicule directly, not me. They OWN this debate.
proverbialwisdom
(4,959 posts)Immune Response to Rubella Vaccine Varies by Race, Ethnicity
February 26, 2014
By Megan Brooks
NEW YORK - A new study finds "consistent" evidence for racial/ethnic differences in humoral immune response to rubella vaccination, say researchers with the Mayo Vaccine Research Group, Mayo Clinic, Rochester, Minnesota.
Individuals of African descent have significantly higher rubella-specific neutralizing antibody levels relative to individuals of European descent and/or Hispanic ethnicity (p<0.001), Dr. Gregory A. Poland and colleagues reported online February 13 in the journal Vaccine.
In an interview with Reuters Health, Dr. Poland said, "We make (vaccine) policy, of course, at the population level. That's a paradigm that seems right and even self-obvious to us. But as we enter into the era of personalized medicine that paradigm is starting to fade away."
"For example, if you come here to the Mayo Clinic for treatment of resistant hypertension or depression or certain malignancies, your treatment is individualized to you based on your genomics. There are people that carry some genes that if we gave them the standard dose of chemotherapy it would kill them. There are others that carry certain genes that if we don't double the dose it does them no good," he explained.
"Nobody has applied that paradigm to vaccine responses. Our group has been pushing the concept of individualized vaccinology or what we call vaccinomics," Dr. Poland said.
<>
SOURCE: http://bit.ly/1mwLIkQ
http://www.sciencedirect.com/science/article/pii/S0264410X14001534 (final edited form, fee)
Vaccine
Volume 32, Issue 17, 7 April 2014, Pages 19461953
Associations between race, sex and immune response variations to rubella vaccination in two independent cohorts
Iana H. Haralambievaa, b, Hannah M. Salka, Nathaniel D. Lamberta, b, Inna G. Ovsyannikovaa, b, Richard B. Kennedya, b, Nathaniel D. Warnerc, V.Shane Pankratzc, Gregory A. Polanda, b, d, ,
a Mayo Vaccine Research Group, Mayo Vaccine Research Group, Mayo Clinic, Guggenheim 611C, 200 First Street SW, Rochester, MN 55905, United States
b Program in Translational Immunovirology and Biodefense, Mayo Clinic, Rochester, MN 55905, United States
c Division of Biostatistics, Mayo Clinic, Rochester, MN 55905, United States
d Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, United States
Received 18 November 2013, Revised 20 January 2014, Accepted 27 January 2014, Available online 13 February 2014
Page search for Thompson: http://www.democraticunderground.com/10025653679
eg. Post 138: http://www.autismspeaks.org/science/science-news/regressive-autism-reported-twice-often-among-african-american-children
NickB79
(19,243 posts)This incompetent study was the result, allegedly, of discussions between Hooker and a senior psychologist at the CDC named William Thompson. For reasons that are still not clear, Thompson, a co-author on an important study by DeStefano et al, confided in Hooker, who, betraying his confidences, recorded much of what he said, an action whose legality is unclear given that its unclear where all of these recordings were made (one party or two party consent states). Hooker then teamed up with Andrew Wakefield to cherry pick bits to make it sound as though Thompson were confessing to some horrible crime of data manipulation to hide this bombshell result reported by Wakefield. Thus was born the CDC whistleblower, who featured prominently in the video likening DeStefano et al and the coverup to the Tuskegee syphilis experiment. Later, Thompson released as statement through his lawyer characterizing the whole problem over DeStefano et al as being a scientific disagreement. Nonetheless, a new conspiracy theory was born: The CDC whistleblower, complete with its own hashtag on Twitter, #CDCwhistleblower. Thompson has said nothing publicly since then, and the mainstream media has basically ignored the story other than an interview with Ronan Farrow of MSNBC that basically trashed the claims of the antivaccine movement.
Would you look at that, Dr. Wakefield strikes again! Gee, who would have guessed?
And Dr. Poland's research does not support Dr. Thompson/Hook/Wakefield's study, despite your desire to think it does. In fact, it sounds from Dr. Poland's statements that we may need to tailor our vaccinations to INCREASE the dosage in people of some ethnicities, given their lower antibody response rate.
proverbialwisdom
(4,959 posts)OTOH, the relevance of Dr. Poland's work? Implicit.
http://www.democraticunderground.com/?com=view_post&forum=1002&pid=2899161
KARE 11 TV Minneapolis: 1 in 8 kids in the local Somali community are affected (with autism) (VIDEO)
http://www.democraticunderground.com/10592519
Boyle on Minneapolis autism research presented at IACC meeting on 1/14/14, including Somali children
proverbialwisdom
(4,959 posts)Expert Rev Vaccines. 2013 Jan;12(1):57-70. doi: 10.1586/erv.12.134.
The genetic basis for interindividual immune response variation to measles vaccine: new understanding and new vaccine approaches.
Haralambieva IH1, Ovsyannikova IG, Pankratz VS, Kennedy RB, Jacobson RM, Poland GA.
Author information
1Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA.
Abstract
The live-attenuated measles vaccine is effective, but measles outbreaks still occur in vaccinated populations. This warrants elucidation of the determinants of measles vaccine-induced protective immunity. Interindividual variability in markers of measles vaccine-induced immunity, including neutralizing antibody levels, is regulated in part by host genetic factor variations. This review summarizes recent advances in our understanding of measles vaccine immunogenetics relative to the perspective of developing better measles vaccines. Important genetic regulators of measles vaccine-induced immunity, such as HLA class I and HLA class II genotypes, single nucleotide polymorphisms in cytokine/cytokine receptor genes (IL12B, IL12RB1, IL2, IL10) and the cell surface measles virus receptor CD46 gene, have been identified and independently replicated. New technologies present many opportunities for identification of novel genetic signatures and genetic architectures. These findings help explain a variety of immune response-related phenotypes and promote a new paradigm of 'vaccinomics' for novel vaccine development.
PMID: 23256739 [PubMed - indexed for MEDLINE] PMCID: PMC3570049
Moonwalk
(2,322 posts)...as it's become much more aware of chemical imbalances and how the brain develops and works, etc. It is a far more science oriented field than it was in the old, Freudian days when it failed to use controls and big enough samples, etc.
A lot more is required in psychiatry for diagnosises. And kid psychologists and therpists are often the first to see an autistic child and so know the signs. There are far more specialists in the field now, and they've learned a great deal, all the way into the womb.
So, please don't disrespect psychiatry on this. It's not your granddad's mistaken notions of Oedipal complexes, etc. They're far more aware of genetic issues and chemical causes behind such disorders than they were even five years ago.
NuclearDem
(16,184 posts)proverbialwisdom
(4,959 posts)Little Tich
(6,171 posts)The problem is that those who promote the link base their beliefs on pseudoscience, and how can you compete with that?
Novara
(5,842 posts)Have you ever tried to have a conversation with someone who believes in pseudoscience? It's like talking to a wall somewhere down the rabbit hole. They believe in what they want to believe in and no amount of facts, studies, science, proof, or logic can sway them. I had such a discussion with someone yesterday (not about vaccines, but some other wacky conspiracy theory), and I walked away, shaking my head in disbelief.
proverbialwisdom
(4,959 posts)NickB79
(19,243 posts)Hell, a few dozen more studies (on top of the dozens already done) and maybe we can start to convince some of the idiot anti-vaxxers out there to get their kids their shots
Seriously though, when I think about the millions of dollars and thousands of hours countless researchers have devoted to rehashing this shit over and over and over again in the past 20 years, and what they could have accomplished instead with that time and money, it makes my blood boil.
Fucking Wakefield and his fraudulent papers. That man deserves to be in prison for the damage he's caused.
proverbialwisdom
(4,959 posts)Lewin Group, Insurer-Owned Consulting Firm, Often Cited in Health Reform Debate
By David S. Hilzenrath
Washington Post Staff Writer
Thursday, July 23, 2009
The political battle over health-care reform is waged largely with numbers, and few number-crunchers have shaped the debate as much as the Lewin Group, a consulting firm whose research has been widely cited by opponents of a public insurance option.
To Rep. Eric Cantor (Va.), the House Republican whip, it is "the nonpartisan Lewin Group." To Republicans on the House Ways and Means Committee, it is an "independent research firm." To Sen. Orrin G. Hatch (Utah), the second-ranking Republican on the pivotal Finance Committee, it is "well known as one of the most nonpartisan groups in the country."
Generally left unsaid amid all the citations is that the Lewin Group is wholly owned by UnitedHealth Group, one of the nation's largest insurers.
More specifically, the Lewin Group is part of Ingenix, a UnitedHealth subsidiary that was accused by the New York attorney general and the American Medical Association of helping insurers shift medical expenses to consumers by distributing skewed data. Ingenix supplied UnitedHealth and other insurers with data that allegedly understated the "reasonable and customary" doctor fees that insurers use to determine how much they will reimburse consumers for out-of-network care.
<>
Lewin's clients include the government and groups with a variety of perspectives, including the Commonwealth Fund and the Heritage Foundation. A February report by the firm contained information that could be used to argue for a national system known as single-payer, the approach most threatening to insurers, Sheils noted.
But not all of Lewin's reports see the light of day. "Let's just say, sometimes studies come out that don't show exactly what the client wants to see. And in those instances, they have (the) option to bury the study," Sheils said.
"The Lewin Group is committed to providing independent, objective and nonpartisan analyses of policy options," the firm said in a recent submission to the House Energy and Commerce Committee. Though it is owned by UnitedHealth, the Lewin Group "has editorial control over all its work products," the firm added.
<>