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Judi Lynn

(160,601 posts)
Mon Jun 1, 2015, 05:14 AM Jun 2015

Doctors hail 'spectacular' cancer treatment breakthrough

Source: Independent Television News (UK)

Doctors hail 'spectacular' cancer treatment breakthrough
1 June 2015 at 4:04am

Doctors have hailed a "spectacular" breakthrough in cancer treatment after a pair of drugs were found to shrink tumours in nearly 60% of people.

A British-led trial on 945 patients with advanced melanoma found treatment with immune-boosting drugs - ipilimumab and nivolumab - stopped the cancer advancing for nearly a year in 58% of cases.

Melanoma is the most serious form of skin cancer and kills more than 2,000 people in Britain each year.

Immunotherapy harnesses the body's immune system to attack cancerous cells.

Experts say the treatment may bring about a "whole new era" for successful cancer care.




Read more: http://www.itv.com/news/2015-06-01/doctors-hail-spectacular-cancer-drug-breakthrough/

37 replies = new reply since forum marked as read
Highlight: NoneDon't highlight anything 5 newestHighlight 5 most recent replies
Doctors hail 'spectacular' cancer treatment breakthrough (Original Post) Judi Lynn Jun 2015 OP
+1000 Sherman A1 Jun 2015 #1
I've Heard For Years That billhicks76 Jun 2015 #2
Google "Rick Simpson oil" DiverDave Jun 2015 #3
This message was self-deleted by its author rjsquirrel Jun 2015 #6
Huh? Quack medicine? DiverDave Jun 2015 #9
Interesting response, calling out someone for calling your post out elias7 Jun 2015 #19
Sorry, Cannabis doesn't have the corporate seal of approval that you're looking for tridim Jun 2015 #26
And this IS why cancer has been around this long Politicalboi Jun 2015 #28
And laetrile! Buzz Clik Jun 2015 #16
Immunotherapy is the most promising area BrotherIvan Jun 2015 #4
This message was self-deleted by its author rjsquirrel Jun 2015 #7
As the child of a mother who died from the treatment of cancer before her cancer did anything BrotherIvan Jun 2015 #8
I understand your frustration, but the problem is certain technologies and understandings needed to still_one Jun 2015 #23
Thanks for the documentary BrotherIvan Jun 2015 #30
Ken burns did an excellent job. A lot of folks have suffered greatly still_one Jun 2015 #32
Yes, the suffering is more awful than anything I could have imagined BrotherIvan Jun 2015 #34
Sorry wrong place, deleting content. n/t sharp_stick Jun 2015 #21
The compounds in this study sharp_stick Jun 2015 #25
rec samsingh Jun 2015 #5
Cannabis! sasquuatch55 Jun 2015 #10
That's nice. Go eat some Cap'n Crunch and let the people talk. Buzz Clik Jun 2015 #15
I caught part of a story on the radio the other day about using viruses to kill cancer cells. A Simple Game Jun 2015 #11
Cuba already has a vaccine against Lung Cancer the U.S. is hoping to access. classykaren Jun 2015 #12
Yes that was it. Maybe we should boycott some more countries just for spite. n/t A Simple Game Jun 2015 #13
More info rocktivity Jun 2015 #35
That was VICE's show on HBO about killing cancer. valerief Jun 2015 #20
They did mention the measles vaccine. n/t A Simple Game Jun 2015 #29
This 27 year Melanoma survivor says... MarianJack Jun 2015 #14
Also movement on the ability to attack Macrophages too. Promising. Cancer sucks!! 7962 Jun 2015 #17
What we can agree on is..... JPK Jun 2015 #18
I wonder if an army of renegade doctors will illegally treat cancer like valerief Jun 2015 #22
There is no magic bullet sharp_stick Jun 2015 #24
"there is no way known, yet, to target the thousands of different cancers. Except now there is... masmdu Jun 2015 #27
Not yet there isn't sharp_stick Jun 2015 #33
I hate cancer. go where the research takes you. littlewolf Jun 2015 #31
It's Coming colsohlibgal Jun 2015 #36
Hmmm. GGJohn Jun 2015 #37

DiverDave

(4,886 posts)
3. Google "Rick Simpson oil"
Mon Jun 1, 2015, 05:22 AM
Jun 2015

Goddamned war on drugs...we could have had an all natural cure years ago.
Yes, CURE

Response to DiverDave (Reply #3)

DiverDave

(4,886 posts)
9. Huh? Quack medicine?
Mon Jun 1, 2015, 05:54 AM
Jun 2015

Every study coming out (years late for dead people) shows that weed stops and actually reverses
the growth of cancer cells.
I bet you didn't even read about it, did you?
Why do you want to defend a policy that has allowed
a lot of folks to suffer?
Sure you are in the right site?

elias7

(4,026 posts)
19. Interesting response, calling out someone for calling your post out
Mon Jun 1, 2015, 09:03 AM
Jun 2015

Untested pseudoscience such as hemp oil may or may not have some validity, but anecdotal evidence is not scientific method. A cure all for such a diverse group of entities is suspect, since any knowledge of the current state of heme/onc treatment modalities shows that chemotherapeutic regimens vary with each type of cancer, and is EVIDENCE BASED. People who like to bitch and moan about big pharma and greed in the medical profession fail to grasp that people like your hemp oil guy have gotten rich off of untested non-evidence based pseudo-panaceas that plays on people's ignorance and magical thinking wishes.

tridim

(45,358 posts)
26. Sorry, Cannabis doesn't have the corporate seal of approval that you're looking for
Mon Jun 1, 2015, 09:58 AM
Jun 2015

Big pharma is damn proud of your laziness and ignorance, it makes them richer every day.

 

Politicalboi

(15,189 posts)
28. And this IS why cancer has been around this long
Mon Jun 1, 2015, 12:05 PM
Jun 2015

For fuck sake Marijuana shrinks cancerous tumors too, and we've known this since 1974. It's people like you who have no faith in what really works because of what it is. Marijuana=quack medicine. Bullshit. St.Judes is quack medicine.

BrotherIvan

(9,126 posts)
4. Immunotherapy is the most promising area
Mon Jun 1, 2015, 05:31 AM
Jun 2015

They've known about it for ages, but the cancer industry has been unwilling to fund the research. Now with breakthroughs like this, maybe we can advance cancer treatment beyond a 100 year-old model. Great news.

Response to BrotherIvan (Reply #4)

BrotherIvan

(9,126 posts)
8. As the child of a mother who died from the treatment of cancer before her cancer did anything
Mon Jun 1, 2015, 05:38 AM
Jun 2015

I don't think my ass is talking.

still_one

(92,372 posts)
23. I understand your frustration, but the problem is certain technologies and understandings needed to
Mon Jun 1, 2015, 09:25 AM
Jun 2015

Last edited Mon Jun 1, 2015, 01:14 PM - Edit history (1)

be discovered first. It is a very complex problem, and the unlocking of the human genome along with other breakthroughs have helped.

What complicates things is that there appears not to be one treatment protocol.

For example, herceptin, which was one of the first breakthroughs at the molecular level for breast cancer, will only be effective for those that are HER2 positive. Same goes for Estrogen and Progesterone suppression therapy, it is helpful only for those that have the genetic makeup where the tumor is Estrogen and Progesterone sensitive.

This is not an easy process, even in this thread, it was the combination therapy that proved effective in the clinical trial.

There was a PBS special that gave an historical perspective of the issues affecting research and why it is so difficult. I highly recommend if you haven't seen it, "The Emperor of All Maladies", by Ken Burns is well worth the time to understand the challenges that make it so difficult.

Like any scientific endeavor the whole process has been a learning exercise, where certain progress could not occur until a good foundation had been set.



BrotherIvan

(9,126 posts)
34. Yes, the suffering is more awful than anything I could have imagined
Mon Jun 1, 2015, 01:38 PM
Jun 2015

I know that once the correct treatment is found people will look on the days of cut/burn/poison as barbaric a practice as bloodletting and leeches.

sharp_stick

(14,400 posts)
25. The compounds in this study
Mon Jun 1, 2015, 09:38 AM
Jun 2015

ipilimumab and nivolumab are both developed and tested by a pharmaceucial company with an entire division devoted to the field of immuno-oncology.

There is plenty of research going on here and it's been going on for a long time.

A Simple Game

(9,214 posts)
11. I caught part of a story on the radio the other day about using viruses to kill cancer cells.
Mon Jun 1, 2015, 07:09 AM
Jun 2015

Didn't catch enough of the story to relate any more than that.

 

7962

(11,841 posts)
17. Also movement on the ability to attack Macrophages too. Promising. Cancer sucks!!
Mon Jun 1, 2015, 08:29 AM
Jun 2015

using an already approved drug, Lymphoseek, to piggyback medicine directly to a tumor site.
http://www.macrophagetherapeutics.com/about-us/

JPK

(653 posts)
18. What we can agree on is.....
Mon Jun 1, 2015, 08:47 AM
Jun 2015

....That the huge amount of money in cancer research and treatment spread across the medical establishment in this country is so vast that it is a cash cow many in the medical establishment have a vested interest in keeping around. Can you imagine if a magic bullet was found? There would be a panic in the industry and possibly a market collapse.

My niece who had cancer when she was fifteen and had her leg amputated as a result of it, her cost of treatment almost reached her one million dollar insurance cap. She's alive today in her mid thirties thankfully but that's a lot of lettuce from just one patient. Now multiply that tens of thousands of times and at today's dollars.

valerief

(53,235 posts)
22. I wonder if an army of renegade doctors will illegally treat cancer like
Mon Jun 1, 2015, 09:22 AM
Jun 2015

history has given us doctors performing abortions when it was illegal. Of course, they'd be labeled quacks and their known cured patients would be reinfected and let to die and held up as propaganda against these doctors. Cuz that's what Big Biz does when their bottom line is affected. Women still went to abortion doctors and many people would still go to undercover cancer doctors.

This could be a bestseller, if nothing else.

sharp_stick

(14,400 posts)
24. There is no magic bullet
Mon Jun 1, 2015, 09:28 AM
Jun 2015

because cancer is not a single disease. It is hundreds of diseases with thousands of different modalities and they don't respond to the same treatment.

The reason ipi and nivo work together on this type of melanoma and not on say colon cancer is that they only work on a few of these modalities. Even knowing this, ipi and nivo work only on about 60% of the patients in the trial.

The idea that nobody in the industry is working on a magic bullet therapy isn't because there's no money in it. It's because there is no way known, yet, to target the thousands of different cancers.

Those of us working on cancer have all had family members and or friends struck with the disease. We aren't holding back because it makes money.

sharp_stick

(14,400 posts)
33. Not yet there isn't
Mon Jun 1, 2015, 01:32 PM
Jun 2015

Dr. Soon-Shiong has some fascinating ideas but they're still in the very early stages.

Activating NK cells and getting them to do what you want them to do and nothing else is very difficult. Their use in diffuse tumors has been met with a lot of unusual toxicities in pre-clinical testing and they have yet to show any significant tumor reduction in established solid tumors.

He hasn't been able to discuss how they plan to target the NK cells to a specific antigenic cell type even if they are able to detect that cell type. The reason behind that may be due more to proprietary technology than not being willing to share ideas but it's also a major stumbling block that researchers have been tripping over for quite some time.

I think the technology of Nantworks will eventually find it's niche in the personalized medicine field where they will provide a proteomic profile of a patient that will allow physicians to best pick the therapeutic strategy for that patient. That of course depends on whether or not they can deliver the proteomic results consistently and quickly.

If they or someone else is able to find a way to actually make and activate the specific NK cells through blood banking it could mean a real shift in how we treat cancer but that's still a lot further off than the video might lead you to believe.

littlewolf

(3,813 posts)
31. I hate cancer. go where the research takes you.
Mon Jun 1, 2015, 01:03 PM
Jun 2015

develop all the weapons you can to destroy this dread disease.

colsohlibgal

(5,275 posts)
36. It's Coming
Mon Jun 1, 2015, 10:24 PM
Jun 2015

And the sooner the better, they are now making real progress.

I saw on girl on "Vice" - she had a brain tumor and was on death's door at 9. The doctors introduced, if I remember right, some changed polio virus, programmed to only go after the cancer cells. Se got worse before she got better but they showed her at 13 or so looking like a normal young teen girl - no cancer present at all in her.

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