Fears of global yellow fever epidemic grow as vaccine stocks dwindle
Source: The Guardian
A last-ditch effort to prevent yellow fever spreading through Kinshasa in the Democratic Republic of the Congo and potentially developing into a global epidemic is to be launched using vaccines containing a fifth of the normal dose because the global stockpile is so low.
Yellow fever is frequently lethal, killing half of those who develop severe symptoms. It is transmitted by the bite of the Aedes aegypti mosquito, which is also responsible for the spread of Zika virus. There is a vaccine which protects people for life, but few adults had been immunised in Angola when yellow fever broke out there in December last year, and in the DRC, to where it has spread.
If it takes hold in Kinshasa, a densely packed city of more than 10 million people, it is feared that infected mosquitoes could travel beyond the central African region, which has been experiencing so severe an outbreak that vaccine stocks are almost exhausted.
There have been nearly 4,000 suspected cases of yellow fever in Angola and more than 2,200 in DRC, with around 400 reported deaths in the two countries, mostly in Angola. Almost 19m doses of vaccine have been administered since January, but there are only 5m left in the emergency stockpile. The vaccine takes a year to make, so even with the handful of manufacturers working flat out, stocks cannot be replenished quickly.
Read more: https://www.theguardian.com/global-development/2016/aug/16/fears-of-global-yellow-fever-epidemic-grow-as-vaccine-stocks-dwindle
closeupready
(29,503 posts)I am glad I got it done (as part of planning for travel to South America) - as I recall, it was basically free, at a university travel clinic (which closed several years back, IIRC).
logosoco
(3,208 posts)At least not that we could find. My daughter traveled to Tanzania to visit her brother (in the Peace Corps). It was hard to find anyone who had the shot, finally we found it at Walgreens. It cost around $150. We also had to go see a doctor to get a prescription for it!
Hortensis
(58,785 posts)doses of vaccine.
closeupready
(29,503 posts)Where does time go, by the way, lol?
Callmecrazy
(3,065 posts)I got the vaccine when I joined the Army back in '86. I remember that shot hurting like hell for three days.
Hortensis
(58,785 posts)"mysteriously disappeared." Hope that 5 M in the emergency stockpile at least is not counting those. A YEAR to manufacture the vaccine? I read up a bit. Most don't develop symptoms, but it's a hemorrhagic illness and of those who do almost half die without intensive care. There is no treatment for yellow fever once contracted, but supportive care in hospital, possibly ICU, is critical to bring the seriously ill through.
Nihil
(13,508 posts)> using vaccines containing a fifth of the normal dose
Unless the vaccines were originally 5 times stronger than they needed to be
(which would be a completely separate problem) then surely this will be a
somewhat pointless exercise in pretending to address the problem
(i.e., giving lots more people a vaccine that isn't going to protect them).
How is that going to help?
(There again, maybe it is a large-scale exercise in evaluating homeopathy ...)
muriel_volestrangler
(101,322 posts)SAGE advised that children under 2 years of age should receive the full dose, however, and it pointed out some practical problems as well, such as the need for millions of smaller syringes. A WHO spokesperson says that problem has been solved by using syringes stored in China and Denmark for polio vaccination programs.
Abramson and other experts argue that the effects of the campaign need to be studied. One important question is safety. The yellow fever vaccine is itself a living virus that can replicate inside the body and, in very rare cases, cause a disease in which the vaccine virus proliferates in multiple organs, often leading to death. Although a lower dose would be expected to lead to fewer side effects, that may not be the case. Some researchers have argued that lower doses may be slower to kick the immune system into gear, which could cause the vaccine virus to linger in the body for longer and actually increase the risk of some side effects. A few studies have found no such effect, but because severe side effects are very rare (about one in 2 million), small trials cannot provide definitive answers.
The other question is efficacy. A recent study on 749 men in Brazil showed that a 46-fold diluted vaccine triggered the same antibody response as a full dose. A study in the Netherlands found that a fifth of a normal dose injected intradermally was just as effective as a normal dose injected subcutaneously (the usual route).
http://www.sciencemag.org/news/2016/08/vaccine-saving-strategy-kicks-battle-against-yellow-fever
Nihil
(13,508 posts)LeftyMom
(49,212 posts)is effective for at least a year. So the thought is that getting as many of those short term doses into people as possible is a better path to stopping the epidemic than giving longer-term immunity to far fewer people.
geek tragedy
(68,868 posts)production much faster.
an epidemic of yellow fever in a massive city with practically zero vaccination levels is really scary stuff.