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Native

(5,942 posts)
Sat Mar 14, 2020, 02:37 PM Mar 2020

France warns against use of anti-inflammatory drugs to tackle coronavirus

Source: Reuters

PARIS, March 14 (Reuters) - France's health minister on Saturday said people should not use anti-inflammatory drugs if they have coronavirus-like symptoms because it could worsen their condition.

"Taking anti-inflammatory drugs (ibuprofen, cortisone ...) could be an aggravating factor for the infection. If you have a fever, take paracetamol," Oliver Veran said on Twitter.

President Emmanuel Macron announced on Thursday school closures and urged people to avoid close contact for fear of propagating the virus that has killed 79 people in France and infected more than 3,600. (Reporting by John Irish; Editing by Catherine Evans)

Our Standards: The Thomson Reuters Trust Principles.

Read more: https://news.trust.org/item/20200314135010-a6ijh/



Paracetamol is another name for Acetaminophen
66 replies = new reply since forum marked as read
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France warns against use of anti-inflammatory drugs to tackle coronavirus (Original Post) Native Mar 2020 OP
I have seen other sources say alternate tylenol and advil - so alternate acetominophen Squinch Mar 2020 #1
Yes, I saw the alternating thing, too. deurbano Mar 2020 #4
this is a new virus - the info will continue to change as updates filter through to us Native Mar 2020 #6
This is true. I don't usually use Tylenol. Glad I bought a bottle before this all Squinch Mar 2020 #8
Wouldn't do the advil... Maxheader Mar 2020 #50
The doctor who took my left kidney out advised Advil - ibuprofen csziggy Mar 2020 #59
Acetaminophen AKA Tylenol BlueIdaho Mar 2020 #2
Is paracetamol not an anti-inflammatory drug? Cirque du So-What Mar 2020 #3
No, it is not. Native Mar 2020 #5
OK. Good to know. Cirque du So-What Mar 2020 #7
"laboring under a misconception" left-of-center2012 Mar 2020 #43
I labored mightily Cirque du So-What Mar 2020 #48
No, it is antipyretic (lowers temp) and analgesic (pain relief) uppityperson Mar 2020 #10
Is it over the counter? or prescription? I've never seen it. ancianita Mar 2020 #24
It's Tylenol SansACause Mar 2020 #27
Ah. Thank you. Got it. ancianita Mar 2020 #29
Paracetemol is the UK version of aspirin. luvtheGWN Mar 2020 #32
Nope. It's acetaminophen. Duppers Mar 2020 #38
Aspirin Rebl2 Mar 2020 #45
I've had RA for the last 2yrs. Duppers Mar 2020 #46
No Layzeebeaver Mar 2020 #39
No. Paracetemol, or acetaminophen (Tylenol) as classified as an anti-pyritic. (Anti-fever). Aristus Mar 2020 #61
Acetaminophen in overly repeated/high doses can be extremely liver toxic. hlthe2b Mar 2020 #9
Thank you for this precautionary info. I do not have Tylenol in my house, BUT I just ordered some. AnotherMother4Peace Mar 2020 #11
Not to mention that the fever will likely not be high and some docs are recommending we let our body Native Mar 2020 #12
Yup... Easier said than done in practice though. hlthe2b Mar 2020 #14
Yes, you're correct: less is better. But if body temp is getting too high I want to have AnotherMother4Peace Mar 2020 #18
Cool washcloth on forehead beats any meds..much safer at140 Mar 2020 #53
Fever is your friend unless it gets to 102 or higher at140 Mar 2020 #52
I believe overuse of Ibuprofen is associated with kidney disease Steelrolled Mar 2020 #15
Yes and can increase risk in both renal patients and those with heart disease. hlthe2b Mar 2020 #16
So is alcohol, nicotine, saturated fats etc at140 Mar 2020 #62
And severe ulcers AwakeAtLast Mar 2020 #64
++++++++1000 at140 Mar 2020 #51
Good to know shanti Mar 2020 #13
People on long term cortisone drugs can't just stop them. Warpy Mar 2020 #17
Thank you. I passed this along. Joinfortmill Mar 2020 #19
And what about people with asthma who use daily inhalers with steroid? pnwmom Mar 2020 #20
I think that is a different steroid. LiberalArkie Mar 2020 #25
Acetaminophen and alcohol Mendocino Mar 2020 #21
Very important info. Thanks for the reminder. Duppers Mar 2020 #42
Which is ironic Aquaria Mar 2020 #58
I've been planning on taking moderate doses of aspirin as an antiinflammatory. Chemisse Mar 2020 #22
IIRC aspirin is anti-inflammatory. It is often the 1st OTCpicked bobbieinok Mar 2020 #23
Aspirin is the worst of the bunch SansACause Mar 2020 #30
iIRC daily aspirin was recommended vs heart attack. Supposedly saved colleague's husband bobbieinok Mar 2020 #44
Ditto with me...nt at140 Mar 2020 #55
Yes, but at a lower dose SansACause Mar 2020 #66
My local Walgreen's had plenty of acetominophen. I told the clerk rzemanfl Mar 2020 #26
I saw this yesterday, and shelved the moonscape Mar 2020 #28
btw - I didn't read the Lancet article to mean all moonscape Mar 2020 #37
Meanwhile, Harvard is still saying ibuprofen is OK muriel_volestrangler Mar 2020 #31
If you've been tracking guidelines from the CDC, WHO, etc., things change almost daily. Native Mar 2020 #33
But this is apparently based on a long-held viewpoint muriel_volestrangler Mar 2020 #35
Saw some abstracts in U.S. journals - like AAI's Journal of Immunology that point to NSAIDs possibly Native Mar 2020 #41
I will probably stick with the off brand Excedrin as it has cstanleytech Mar 2020 #34
Aspirin is an anti-inflammatory muriel_volestrangler Mar 2020 #36
I know but its been the only thing that has worked for me in the past when I have had a cold or the cstanleytech Mar 2020 #47
Just watch stomach bleeding with aspirin at140 Mar 2020 #56
I am diabetic so I tend to be extra careful when it comes to things that cstanleytech Mar 2020 #57
Caution with acetaminophen, i.e., Tylenol. It can quickly be toxic to the liver. Texin Mar 2020 #40
In elementary school Chainfire Mar 2020 #49
It is a wonder drug and has important uses Pachamama Mar 2020 #54
BER aspirin stopped many chest pains for me at140 Mar 2020 #60
Thanks for sharing this. ooky Mar 2020 #63
NSAIDs have anti-coagulant properties. roamer65 Mar 2020 #65

Squinch

(50,950 posts)
1. I have seen other sources say alternate tylenol and advil - so alternate acetominophen
Sat Mar 14, 2020, 02:41 PM
Mar 2020

and NSAIDs to keep fever down.

Now I am confused! DU doctors: which is it?

Native

(5,942 posts)
6. this is a new virus - the info will continue to change as updates filter through to us
Sat Mar 14, 2020, 02:50 PM
Mar 2020

everything I've seen thus far from credible sources outside of the U.S. has come to be accepted in the U.S. several days after the fact. That doesn't mean that France has it right and we have it wrong, but we've consistently been wrong on just about everything so far, so a rational person might want to consider that when deciding what they should do.

Squinch

(50,950 posts)
8. This is true. I don't usually use Tylenol. Glad I bought a bottle before this all
Sat Mar 14, 2020, 02:53 PM
Mar 2020

started. Thanks for the info.

csziggy

(34,136 posts)
59. The doctor who took my left kidney out advised Advil - ibuprofen
Sat Mar 14, 2020, 09:07 PM
Mar 2020

And told me to not take acetaminophen or naproxen. He said ibuprofen was easier on the kidney I have left.

Rebl2

(13,514 posts)
45. Aspirin
Sat Mar 14, 2020, 05:31 PM
Mar 2020

reduces inflammation whereas acetaminophen does not. I know because I have had rheumatoid arthritis for 50 plus years and it was drilled into my head many years ago.

Duppers

(28,123 posts)
46. I've had RA for the last 2yrs.
Sat Mar 14, 2020, 05:40 PM
Mar 2020

It's important that folks know the big difference in pain relief and anti-inflammatory meds.

My dog also has arthritis. I take my nightly dose of daily aspirin with her sans the weiner.

Aristus

(66,380 posts)
61. No. Paracetemol, or acetaminophen (Tylenol) as classified as an anti-pyritic. (Anti-fever).
Sat Mar 14, 2020, 09:21 PM
Mar 2020

It doesn't have the anti-inflammatory property of ibuprofen, naproxen, etc.

hlthe2b

(102,282 posts)
9. Acetaminophen in overly repeated/high doses can be extremely liver toxic.
Sat Mar 14, 2020, 02:57 PM
Mar 2020

so just a little bit of caution here. Despite their decades-long advertising campaign designed to suggest otherwise, Tylenol (acetaminophen) is not without risk and should be used with similar caution to other OTC pain medications.

I'm not sure this advice is without controversy nor based as of yet, on firm evidence. Granted we are learning as we go. In some patients, there is evidence of cytokine storm, a sign of a "hyper-immune" systemic reaction (in the most seriously affected patients with pneumonia and rapid downward spiral--suggesting they may actually be indications for steroids to DIMINISH the body's immune and inflammatory response).

Still, I think it wise to be cautious with both NSAIDs (Ibuprofen, Naproxen, aspirin--even more caution due to Reye Syndrome for Children) and tylenol (acetaminophen). Moderation. More is not better.

AnotherMother4Peace

(4,246 posts)
11. Thank you for this precautionary info. I do not have Tylenol in my house, BUT I just ordered some.
Sat Mar 14, 2020, 03:10 PM
Mar 2020

I have a high risk household, & am making every effort to take precautions. We've always taken just plain aspirin, and it's always worked just fine: simple: take with food, every 4 hours. - Don't over do it because of the blood thinning qualities.

So just on this bit of info I've tacked Tylenol onto an order that will be arriving (hopefully) on Tuesday morning. My local Vons usually delivers next day, but now it's about a week.

Native

(5,942 posts)
12. Not to mention that the fever will likely not be high and some docs are recommending we let our body
Sat Mar 14, 2020, 03:14 PM
Mar 2020

temp do what it can and not take anything unless the fever gets high. But you know how people pop pills the minute they feel a twinge or their temp gets to 99 degrees. I'm glad they are at least warning people of complications that can arise based on their experience in treating this clever virus. Here in the U.S. we get charts that are scripted for 6-year-olds. The giant board chart from yesterday's Rose Garden debacle was completely inane. I'm still not over that.

AnotherMother4Peace

(4,246 posts)
18. Yes, you're correct: less is better. But if body temp is getting too high I want to have
Sat Mar 14, 2020, 03:30 PM
Mar 2020

the safest fever reducer for members of my household. That and other ways to reduce fever: cool towel, loosen clothing, etc.

at140

(6,110 posts)
52. Fever is your friend unless it gets to 102 or higher
Sat Mar 14, 2020, 07:20 PM
Mar 2020

Fever is a natural response by the body in attempt to kill the infection.
It is like bringing summer weather inside body.
But excessive fever is dangerous. In any case keep well hydrated.

 

Steelrolled

(2,022 posts)
15. I believe overuse of Ibuprofen is associated with kidney disease
Sat Mar 14, 2020, 03:20 PM
Mar 2020

So ideally you use drugs like this only when needed. Of course some people don't have a choice.

hlthe2b

(102,282 posts)
16. Yes and can increase risk in both renal patients and those with heart disease.
Sat Mar 14, 2020, 03:24 PM
Mar 2020

Aspirin, of course, holds risks for gastric bleeding and for those on blood thinners.

On the other hand, moderate and occasional use of any of these for MOST people can be safe. All in moderation.

shanti

(21,675 posts)
13. Good to know
Sat Mar 14, 2020, 03:20 PM
Mar 2020

I bought some Tylenol by mistake last month. It doesn't really work for me on pain, so I usually use Motrin, which works great. Now I'll have the right med if I get sick.

Warpy

(111,267 posts)
17. People on long term cortisone drugs can't just stop them.
Sat Mar 14, 2020, 03:24 PM
Mar 2020

NSAID drugs, including aspirin, are fever reducing drugs, Cortisone surpresses the immune system but NSAIDs don't, the mechanism is quite different.

The advice to alternate NSAIDs and Tylenol is prebably good, NSAIDs are extremely hard on the kidneys, Tylenol on the liver.

Be aware that every crank is going to be out there dispensing advice, much of it bad. Run everything by your doctor if you are ill.

Mendocino

(7,495 posts)
21. Acetaminophen and alcohol
Sat Mar 14, 2020, 04:12 PM
Mar 2020

Excessive drinking, 3+ drinks daily is very hard on the liver. Many doctors recommend no drinking at all if taking it.

 

Aquaria

(1,076 posts)
58. Which is ironic
Sat Mar 14, 2020, 08:33 PM
Mar 2020

Given that two of the primary ingredients in NyQuil are alcohol and acetaminophen. Not a good combination.

And ZzQuil, or whatever it's called is nothing more than liquid diphenydramine. Or Benadryl as it's more commonly known. You can buy a bottle of 500 diphenydramine pills for less than what Zzquil costs, and it does the same thing.

Chemisse

(30,813 posts)
22. I've been planning on taking moderate doses of aspirin as an antiinflammatory.
Sat Mar 14, 2020, 04:37 PM
Mar 2020

as a strategy against the inflammation caused by an over-reactive immune system, if I should be one of those who becomes seriously ill.

Yes, I know aspirin is a blood thinner, but all the NSAIDS have significant risks. I still prefer aspirin over the alternatives.

I am curious about what scientific information supports this recommendation.

High doses of aspirin are thought to have contributed to the deaths of people in the 1918 influenza, as blood-filled lungs were detected in autopsies. In those days there were not recommendations for dosage and people took quite high amounts of it in the hopes that it would cure the disease.



SansACause

(520 posts)
30. Aspirin is the worst of the bunch
Sat Mar 14, 2020, 04:53 PM
Mar 2020

I'm surprised it's even being sold. It can cause stomach ulcers and stomach bleeding.

rzemanfl

(29,565 posts)
26. My local Walgreen's had plenty of acetominophen. I told the clerk
Sat Mar 14, 2020, 04:47 PM
Mar 2020

it might become the next toilet paper when I bought some.

moonscape

(4,673 posts)
28. I saw this yesterday, and shelved the
Sat Mar 14, 2020, 04:49 PM
Mar 2020

alternating ibuprofen/acetaminophen idea forthwith.

Also, it explains why those with hypertension might be showing higher vulnerability. Lisinopril, etc.

https://www.thelancet.com/pdfs/journals/lanres/PIIS2213-2600(20)30116-8.pdf

edit: can't figure out how to fix the link, will have to copy/paste

moonscape

(4,673 posts)
37. btw - I didn't read the Lancet article to mean all
Sat Mar 14, 2020, 05:13 PM
Mar 2020

anti-inflammatory meds necessarily as it called out only ibuprofen specifically, but the science loses me.

Hypertension is also treated with ACE inhibitors and ARBs, which results in an upregulation of ACE2.5 ACE2 can also be increased by thiazolidinediones and ibuprofen.

It's a hypothesis, re risk of ACE2-increasing drugs as CV attaches to cells via the ACE2 enzyme.

muriel_volestrangler

(101,320 posts)
31. Meanwhile, Harvard is still saying ibuprofen is OK
Sat Mar 14, 2020, 04:54 PM
Mar 2020
What treatments are available to treat coronavirus?

Currently there is no specific antiviral treatment for COVID-19. However, similar to treatment of any viral infection, these measures can help:

While you don't need to stay in bed, you should get plenty of rest.
Stay well hydrated.
Take acetaminophen, ibuprofen, or naproxen to reduce fever and ease aches and pains. Be sure to follow directions. If you are taking any combination cold or flu medicine, keep track of all the ingredients and the doses. For acetaminophen, the total daily dose from all products should not exceed 3,000 milligrams.

https://www.health.harvard.edu/diseases-and-conditions/coronavirus-resource-center

Native

(5,942 posts)
33. If you've been tracking guidelines from the CDC, WHO, etc., things change almost daily.
Sat Mar 14, 2020, 05:04 PM
Mar 2020

A couple of days ago the EU's CDC (ECDC) specified that you could only get sick from someone showing symptoms. A day or so ago, Singapore and China said respectively that 2/3 and 3/4 of those infected became infected by people who were asymptomatic. Those numbers are being kicked around by a couple of other countries to help verify them, but even if those estimates are grossly inflated, that's a heck of a lot of people picking up the virus from people who aren't showing symptoms.

Bottom line - the info changes constantly as experts learn more. All we can do is sift through it all, ignore what Trump is saying, and rely on what appears to be sound information - information that hasn't been coming from the U.S.

muriel_volestrangler

(101,320 posts)
35. But this is apparently based on a long-held viewpoint
Sat Mar 14, 2020, 05:10 PM
Mar 2020
Health officials point out that anti-inflammatory drugs are known to be a risk for those with infectious illnesses because they tend to diminish the response of the body’s immune system.

The health ministry added that patients should choose paracetamol because “it will reduce the fever without counterattacking the inflammation”.

French patients have been forced to consult pharmacies since mid-January if they want to buy popular painkillers, including ibuprofen, paracetamol and aspirin, to be reminded of the risks.

Jean-Louis Montastruc, the head of pharmacology at Toulouse hospital, told RTL radio: “Anti-inflammatory drugs increase the risk of complications when there is a fever or infection.”

https://www.theguardian.com/world/2020/mar/14/anti-inflammatory-drugs-may-aggravate-coronavirus-infection

But, more information from outside the USA:

Do
...
drink plenty of water and take everyday painkillers, such as paracetamol and ibuprofen, to help with your symptoms

https://www.nhs.uk/conditions/coronavirus-covid-19/self-isolation-advice/

Native

(5,942 posts)
41. Saw some abstracts in U.S. journals - like AAI's Journal of Immunology that point to NSAIDs possibly
Sat Mar 14, 2020, 05:25 PM
Mar 2020

impairing antibody production to certain infections. Thanks for your post. Good info.

at140

(6,110 posts)
56. Just watch stomach bleeding with aspirin
Sat Mar 14, 2020, 07:24 PM
Mar 2020

because it is a blood thinner. I take coated low dose aspirin weekly
but usually with food.

cstanleytech

(26,291 posts)
57. I am diabetic so I tend to be extra careful when it comes to things that
Sat Mar 14, 2020, 07:58 PM
Mar 2020

can mess with the liver or stomach as I do not need anymore complications by adding more problems on top of it.

Texin

(2,596 posts)
40. Caution with acetaminophen, i.e., Tylenol. It can quickly be toxic to the liver.
Sat Mar 14, 2020, 05:25 PM
Mar 2020

It is contraindicated for persons with any kind of liver complications/disease, and if a person drinks alcohol routinely.

I've seen alternating between acetaminophen and ibuprofen. And just a person tidbit, Aleve, i.e. Naproxin can wreak havoc with eyesight after a couple of days.

Chainfire

(17,542 posts)
49. In elementary school
Sat Mar 14, 2020, 07:09 PM
Mar 2020

They taught us that Aspirin was the wonder drug. Maybe it's time has come again.....

(if you want to take medical advice from a plumber)

Pachamama

(16,887 posts)
54. It is a wonder drug and has important uses
Sat Mar 14, 2020, 07:21 PM
Mar 2020

It is on the WHO list of essential drugs.

It is an important blood thinner and saves lives.
This thread is irritating me because people are not Doctors and making comments that just aren’t factual.

at140

(6,110 posts)
60. BER aspirin stopped many chest pains for me
Sat Mar 14, 2020, 09:19 PM
Mar 2020

BER = not beer, it is Before Exercise Routine began in my life.

ooky

(8,923 posts)
63. Thanks for sharing this.
Sat Mar 14, 2020, 09:43 PM
Mar 2020

I take an anti-inflammation drug to manage inflammation from osteo-arthritis. I may need to stop using it if I develop this virus. If I hadn't read it here I might have missed that important information.

That's one of the big things I really love about this site and the people that share so much helpful information here.

roamer65

(36,745 posts)
65. NSAIDs have anti-coagulant properties.
Sat Mar 14, 2020, 10:26 PM
Mar 2020

Especially aspirin. Not the best choice when you have possible hemorrhagic viral pneumonia.

Aspirin was not a big help in the 1918-1920 epidemic.

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