was probably worth it.

This is no cure.

He suffered from the fevers until the day he died.

This was used to ease the symptoms a bit.

He quit using it as it was making him sicker than the malaria was.

He contracted it during WWII while serving in Guadalcanal.

Whodathunkit?

He wants success. Let’s hope it is. I don’t know if they are the same drugs as China, but I trust the governor to keep an out on people participating in the trial and I know he will.

dump stood in front of the people and claimed this was a cure practically!

You Abadanassad best check your memory.

Did you see him giving his two-bit speech pushing this crap?

Side effect is SUICIDE!

Enjoy your brief time here btw.

They don't have the luxury of waiting on the FDA to complete a blind randomized test against a control group. I hope beyond hopes that it helps people recover and reduces the deaths from this disease.

He's selling bullshit

Stop

No one an where has dosed 1 gram a day with this drug. This is propaganda and made up nonsense. It is a synthetic derivative of quinine that has been used for decades and dosage toxicity is known.

Hate Trump all you want, but this drug has actual promise to help alleviate symptoms and this article is trash.

I develop drugs for a living and have been following the use of hydroxychloroquine for several months.

I guaranty you this article is not accurate and can back it up with legitimate research if you really want me to do that again.

In my lifetime I've used medications that had to be closely monitored. With some, abstinence from alcohol was required. And yet I"m still here because I followed the guidelines. Anybody who shies
away from using potentially uselfel treatment for COVID-19 due to alarmist ops like the original here
deserves whatever happens to them...

is the drug related to quinolone type medicine ? Is it similiar to Lariam ?
Is it connected to CYP 450 clearance ?
tia

It is similar to Lariam. Both are antimalarials. They are in the same family of drugs.

No on CYP 450. That is an enzyme. The important MOA for the quines here is that they are zinc ionophores. They increase zinc absorption and that slows the action of the RdRP from the virus and reduces creation of new viruses. That is what the in vitro trials showed at least.

A study that looks at the association of CYP 450 and hydroxychloroquine in lupus patients. https://www.ncbi.nlm.nih.gov/pubmed/26316040

she stopped taking chloroquine rather early on. She had stomach pain, nausea, headaches, dizziness, hearing and vision problems. Continued use could have led to seizures and serious heart issues.

Mcgs = micrograms

60 micrograms = .06 miligrams


Check your units please

Please

The link is up and down. Try it again. I think the article must be getting tons of traffic.

Korea was dosing 400mg per day of hydroxychloroquine. I will find that reference for you also.

Hydroxychloroquine is less toxic than chloroquine.

I suspect a typo.

It seems low and could be 600mg daily. Early on for something like this the info is unreliable. I was saying 60mcgs because that was what the headline said yesterday.

500 mg up to 2x's day of chloroquine phosphate.

I would not feel safe taking it at that dose.

I malarial prophylactic dose is 500 mg 1 X's a week.

If that were protective, we would have a game changer

Apparently there is a randomized blind study with 80 participants for Favipiravir that was released yesterday and showed statistically significant improvement in Covid-19 patients treated with the drug. I have not found the study yet. But it looks like we are circling in on some therapies that will help in at least some cases.

https://www.cleveland.com/news/2020/03/japanese-drug-making-waves-treating-coronavirus-will-it-come-to-us.html

but still way under the dosage in the original article.

That is what is used for malaria.

This is a well-known and long prescribed drug.

Last edited Sat Mar 21, 2020, 01:34 AM - Edit history (1)

The side effects of it were not good.

For one thing, the stuff has a very ugly odor to it.

You know it is toxic.

That is why people quit using it as it used to be put in Schweppes Tonic Water, the "tonic" was the quinine. The taste was awful and so was its effects.
As I recall, Schweppes Tonic Water was changed and less of the "tonic" was put in it as well c. 1960 or so.

So, no great effects, less tonic in the water, no reason to drink it seems to be what I recall.



Schweppes Indian Tonic Water is part of the Schweppes Mixers range.

They can be enjoyed on their own or combined with alcohol or fruit juice.

Below you'll find some important information about Schweppes Indian Tonic Water - ingredients, nutritional values and reference intake (RI) information - to help you make informed choices.

Ingredients:

Carbonated Water, Sugar, Citric Acid, Acidity Regulator (Sodium Citrate), Flavourings (Including Quinine), Sweetener (Aspartame, Acesulfame K). Contains a source of Phenylalanine.

This was a way to make money off of a pandemic.

It is the HOAX!

to do. He lies about everything. Either he's covering his ass or he's heard some stupid thing on Pox or from party buddy.

If he told me the sky was up, I'd have to run out and check.

This is Bizarro World after all.

Symmetrel (amantidine) is used to treat Parkinson's symptoms, malaria and
is sometimes used as an antiviral. My experience with the drug is that it is not
"deadly" unless you overdose on the stuff. I give it to patients sometimes to treat
side effects of antipsychotic medication (pseudoparkinsonian symptoms)

Whenever a new strain of a virus comes on the scene, amantidine has been given
with the hope of curtailing the severity of symptoms. If I recall, they did this with
the H1N1 virus. It's worth a trial because the risk outweighs the benefit by a mile.

I'm confused about the quinine-based malaria drug because that is not used as an
antiviral. It changes th Ph of the blood. It is also used to treat heart arhythmias. I
assume that it is effecting the heart rhythyms of people. Quinine was banned by
the FDA in 2006, so it seems unlikely the U.S. will use it. For a long time, we used
it to treat leg cramps in opiate withdrawal -- until it was found to be dangerous!

And spike protiens which is how SARs viruses enter cells.

cited the changed pH level in the blood as what her rheumatology community thinks might be what interferes with the virus.

both SARS use the same method (attach to the same ACE receptors) to infect humans.

keeping the virus from connecting via the ACE receptors and stopping the action of the RdRP once the messenger RNA gets into the cell to limit virus production.

Link to tweet

Dr. Orange has saved us all.
Didn’t even have to go to med school.

(Insert 17 sarcasm alerts here)

in the Peace Corps. Many people complained of side effects, but the only time I did was when I double-dosed by accident. It caused some very weird vision problems for a few hours.

It might work in some cases and might not. Let the expert's figure it out. Its a relatively safe drug that's been around forever. I know many people that has used it.

My father had malaria.

As I mentioned, he quit using it as it was not helping him much if at all.

He died with those oh so familiar fevers and sweat pouring down his face.

A veteran called in to Thom Hartmann's radio show earlier in the week and said the military is forbidden to administer this drug to soldiers for anything other than malaria because some people have an adverse reaction to one of the chemicals in the drug that could literally kill them on the spot! I only get his show when I'm on the road because I live in a remote rural area, so I only caught the tail end of this segment.

I don't know if program transcripts are available for more complete details about the conversation, but maybe check out his website if you want more info on that. (I realize that there are many DUers who just dismiss anything Hartmann says because they think he's a commie due to his very short-term contract with the RT studio, but I, for one, have been a faithful listener since 2004 and forgive him for his short-sighted mistake, from which he learned and corrected.)

We have enough trouble just getting folks tested for COVID-19, much less having to also test them for deadly allergies to a malaria drug. Trump just doesn't care who he kills. If he can deliver fake hope with fake news, that's all he cares about.

Last edited Sat Mar 21, 2020, 02:55 PM - Edit history (1)

As I posted above, my Dad had malaria. He used this for quite awhile and gave up because it was doing him far more harm than good.

Daily rather than just one?



Add questionable drug pusher (profit on this too?) to his list?

If Trump says it’s worth trying, I believe my president. Fuck what the so-called experts and doctors say, Trump is a very, very, very smart guy.

I’m not putting up a sarcasm banner. I would hope it’s not necessary

Link to tweet