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Julian Englis

(2,309 posts)
Mon Mar 19, 2012, 05:53 PM Mar 2012

Shock Therapy’s Effect on Depression Discovered, Researchers Say

Source: Bloomberg

After using electroconvulsive therapy for more than 70 years to treat severe depression, doctors say they now have discovered how it works.

Shock therapy, in use since 1937, appears to tamp down an overactive connection between two parts of the brain involved in emotional processing, thinking and concentration, according to a study released today by the Proceedings of the National Academy of Sciences.

The procedure mimics a seizure, sending a brief electric current to the brain. ECT has the strongest supporting data among treatments for patients whose depression doesn’t respond to medication, according to the American Psychiatric Association. About 10 to 20 percent of depressed patients receive shock therapy, said Paul Holtzheimer, an associate professor of psychiatry and surgery at Dartmouth Medical School.

“This gives us a much more powerful view of the brain,” Holtzheimer, who wasn’t involved in the study, said today in a telephone interview. “If this study holds up, it tells us this is a network problem.”

In the study, nine patients scheduled to undergo shock therapy had their brains scanned using functional MRI before and after treatment. This type of imaging detects blood flow to specific areas of the brain. Then the researchers analyzed the brain’s connectivity using a new mathematical model.

Read more: http://www.bloomberg.com/news/2012-03-19/shock-therapy-s-effect-on-depression-discovered-researchers-say.html



ECT is actually very safe compared to medications. The problem is with the side effects. In, particular some people memory loss. This new information may help pave the way to better, safer treatment of depression, where the treatment is more carefully targeted to parts of the brain that most involved in causing the depression.

Here is a link to the abstract of the original article in the Proceeding of the National Academy of Science:
http://www.pnas.org/content/early/2012/03/12/1117206109.abstract?sid=293419e9-94ec-44d4-be58-b49a2740a56d
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Shock Therapy’s Effect on Depression Discovered, Researchers Say (Original Post) Julian Englis Mar 2012 OP
Below's a link to a better popular press explanation Julian Englis Mar 2012 #1
Okay, I'm just a layperson speaking, but Quantess Mar 2012 #2
Look at the side effects that antidepressants can cause--they are listed on the package inserts. Julian Englis Mar 2012 #7
It cures people very quickly Sgent Mar 2012 #8
I think I know the answer. . . BigDemVoter Mar 2012 #16
The memories lost Control-Z Mar 2012 #18
You better not get depressed again......are you depressed anymore..? MindMover Mar 2012 #3
Barbaric bullshit nebenaube Mar 2012 #4
Actually, ECT cause a growth in synapses. Depression is torture. ECT curing it is a miracle. Julian Englis Mar 2012 #5
A billion synapses here, a billion synapses there.... pretty soon you're talking about WheelWalker Mar 2012 #6
Let's all just emote at media buzzwords to describe a treatment! (nt) Posteritatis Mar 2012 #19
I had a beautiful cousin that had depression. She would cry all the time for no reason and she southernyankeebelle Mar 2012 #9
My condolences for your loss. Depression is a terrible disease that can be so hard to treat. Julian Englis Mar 2012 #10
Thank you so much. You know I think have this kind of depression is worse than even cancer. southernyankeebelle Mar 2012 #12
"Sounds like the g--damned Spanish Inquisition" Trillo Mar 2012 #11
when I was 14 I remember my dad with the shaved hair from electric shock treatments Skittles Mar 2012 #13
ECT is barbaric, there are lots of horror stories about it's use. Odin2005 Mar 2012 #14
Heads up. ECT is NOT Safe! ananda Mar 2012 #15
Heads up, you're wrong. No where even near right. Julian Englis Mar 2012 #17
Tell that to Jack Nicholson. Kablooie Mar 2012 #20

Quantess

(27,630 posts)
2. Okay, I'm just a layperson speaking, but
Mon Mar 19, 2012, 06:08 PM
Mar 2012

how can they say "ECT is actually very safe compared to medications", when it causes memory loss? Because to me, it sounds like it diminishes the brain's higher functioning.

Julian Englis

(2,309 posts)
7. Look at the side effects that antidepressants can cause--they are listed on the package inserts.
Mon Mar 19, 2012, 06:34 PM
Mar 2012

These drugs have numerous side effects and can be dangerous. That's why they are not sold over the counter.

Sgent

(5,857 posts)
8. It cures people very quickly
Mon Mar 19, 2012, 06:37 PM
Mar 2012

Drugs often don't work, require adjustments, adjuncts, etc. in treatment resistant depression and can take months. If someone is in severe depression, ECT works quickly and eliminates the chance of suicide.

BigDemVoter

(4,150 posts)
16. I think I know the answer. . .
Mon Mar 19, 2012, 09:11 PM
Mar 2012

It's usually used only in SEVERE cases of depression where the danger of suicide is very, very high. It is considered a FAST & EFFECTIVE treatment (generally one has + results in 3-4 treatments). Although, as you said, there is memory loss, the efficacy cannot be disputed, especially when even the best anti-depressants take usually 3-4 weeks to have ANY effect.

So, on a pure risk assessment level, the risk is considered to be acceptable when the alternative may very well be suicide.

On Edit: There are some interesting guidelines in California about obtaining informed consent from patients who undergo ECT. See below.

State of California - Health and Human Services Agency Department of Mental Health
ELECTROCONVULSIVE TREATMENT (ECT), INFORMED CONSENT FORM
MH 300 (11/90)
DO NOT SIGN THIS FORM UNTIL YOU HAVE ALL THE INFORMATION YOU DESIRE
CONCERNING ELECTROCONVULSIVE TREATMENT (ECT).
The nature and seriousness of my mental Condition, for which ECT is being recommended, is

RECOMMENDATION: I understand that ECT involves passage of an electrical stimulus across my brain
for a few seconds, sufficient to induce a seizure. In my case the treatments will probably be given
________ times per week for _______ weeks, not to exceed a total of ________ treatments and not to
exceed 30 days from the first treatment. Additional treatments cannot be given without my written consent.
Reasonable alternative treatments (such as psychotherapy and/or medication) have been considered and
are not presently recommended by my doctor because
IMPROVEMENT: I understand that ECT may end or reduce depression, agitation and disturbing thoughts.
In my case there may be permanent improvement, no improvement, or the improvement may last only a
few months. Without this treatment my condition may improve, worsen or continue with little or no change.
SIDE EFFECTS AND RISKS: I understand there is a division of opinion as to the effectiveness of this
treatment as well as uncertainty as to how this procedure works.
I also understand this treatment may have brief side effects: headaches, muscle soreness and
confusion.
There may be some memory loss which could last less than an hour or there may be a permanent
spotty memory loss. Memory loss and confusion may be lessened by the use of unilateral (one-sided)
electrical brain stimulation rather than bilateral (two-sided) stimulation.
Anesthesia and muscle relaxants will be used during these treatments to prevent accidental injury.
Oxygen will be administered to minimize the small risk of heart, lung, brain malfunction or death as a
result of the anesthesia or treatment procedures.
My physician states I have the following medical condition(s) which increase the risk in my case, as
follows:
I HAVE THE RIGHT TO ACCEPT OR REFUSE THIS TREATMENT. IF I CONSENT, I HAVE THE
RIGHT TO REVOKE MY CONSENT FOR ANY REASON AT ANY TIME PRIOR TO OR BETWEEN
TREATMENTS.
Dr. _____________________________ has explained the above information to my satisfaction. At least
24 hours have elapsed since the above information was explained to me. I have carefully read this form or
had it read to me and understand it and the information given to me.
I HEREBY CONSENT TO ECT
Signature D

Control-Z

(15,682 posts)
18. The memories lost
Mon Mar 19, 2012, 10:57 PM
Mar 2012

are supposed to be only inconsequential ones. I'm not sure how true that is. I mean if you can't remember what you've forgotten how do you know whether it was important or not?

To actually cure depression, though, the risk would be worth it to some people I would imagine.

MindMover

(5,016 posts)
3. You better not get depressed again......are you depressed anymore..?
Mon Mar 19, 2012, 06:09 PM
Mar 2012

<a href="http://www.flickr.com/photos/41483660@N04/6851947042/" title="Clive, Colin (Frankenstein)_02 by pbmus, on Flickr"><img src="" width="500" height="362" alt="Clive, Colin (Frankenstein)_02"></a>

 

nebenaube

(3,496 posts)
4. Barbaric bullshit
Mon Mar 19, 2012, 06:18 PM
Mar 2012

Depressed? We'll just fry a few million synapses and you won't be cognate enough to worry about anything. This is torture.

Julian Englis

(2,309 posts)
5. Actually, ECT cause a growth in synapses. Depression is torture. ECT curing it is a miracle.
Mon Mar 19, 2012, 06:24 PM
Mar 2012

Sounds like someone has bought into either the Church of Scientology or big pharma.

WheelWalker

(8,955 posts)
6. A billion synapses here, a billion synapses there.... pretty soon you're talking about
Mon Mar 19, 2012, 06:28 PM
Mar 2012

a real bum trip.

 

southernyankeebelle

(11,304 posts)
9. I had a beautiful cousin that had depression. She would cry all the time for no reason and she
Mon Mar 19, 2012, 06:50 PM
Mar 2012

couldn't tell you why she cried. She was my favorite cousin. She was in and out of hospitals. They gave her the shock treatment. Her parents took her to Lords in France, they took her to Switzerland, and back again. Nothing helped her depression. Finally several years later I guess she had enough. She was taking a nap. Her mother told the cook not to wake her let her sleep. So they were all eating and the next thing you hear her go to the kitchen wanting to know why she wasn't woken up and the cook told her she then went to the balcony and jumped off. She manged to live for a week in a coma. She finally died. She was such a lovely girl and never wanting to hurt anyone. She was kind and when she wasn't in that depression state she was so much fund. It's has been over 40 yrs and I still miss my beautifiul cousin. Depression is a terrible thing a person goes through.

Julian Englis

(2,309 posts)
10. My condolences for your loss. Depression is a terrible disease that can be so hard to treat.
Mon Mar 19, 2012, 06:56 PM
Mar 2012

Treatment now is still very imperfect. Still, this research offers some hope for better treatment in the future.

Trillo

(9,154 posts)
11. "Sounds like the g--damned Spanish Inquisition"
Mon Mar 19, 2012, 07:40 PM
Mar 2012

to borrow a phrase from Doc McCoy.

overactive connection between two parts of the brain involved in emotional processing, thinking and concentration,


Perhaps the real breakthrough will occur when our culture stops demanding we think, concentrate, and be empathic when those connections are first forming, then later deciding that gee, maybe that wasn't such a good idea after all, so now we want to charge you to fix the problem the rest of us caused for you in the first place.

Skittles

(153,160 posts)
13. when I was 14 I remember my dad with the shaved hair from electric shock treatments
Mon Mar 19, 2012, 08:20 PM
Mar 2012

I was visiting him in a mental ward and he did not know who I was; 40 years later I can still remember it like it was yesterday

Odin2005

(53,521 posts)
14. ECT is barbaric, there are lots of horror stories about it's use.
Mon Mar 19, 2012, 08:40 PM
Mar 2012

No thanks. it belongs in the same dustbin as lobotomies.

Julian Englis

(2,309 posts)
17. Heads up, you're wrong. No where even near right.
Mon Mar 19, 2012, 10:21 PM
Mar 2012

Go to PubMed, look up electroconvulsive therapy and safety. Studies show its actually safer than medication.

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