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HuckleB

(35,773 posts)
Mon Oct 28, 2013, 05:11 PM Oct 2013

Ben Goldacre's All Trials Registered | All Results Reported Campaign.

Here's the link to the main web page, with a chance to sign the petition.

http://www.alltrials.net/

Once you're there, click on the link with the title below to learn what it's all about.

The AllTrials campaign calls for all past and present clinical trials to be registered and their results reported.

"Clinical trials are investigations designed to assess the effects – wanted and unwanted – of healthcare interventions in people. The Declaration of Helsinki, which is the World Medical Association’s statement of principles for medical research involving people, states that every investigator running a clinical trial should register it and report its results. Millions of volunteers have participated in clinical trials to help find out more about the effects of treatments on disease, yet that important ethical principle about reporting has been widely ignored. Information on what was done and what was found in these trials could be lost forever to doctors and researchers, leading to bad treatment decisions, missed opportunities for good medicine, and trials being repeated. This is what led to the AllTrials campaign in January 2013, a campaign which is now supported by thousands of individual patients, clinicians and researchers across the world, and by hundreds of organisations representing millions of people.

This document sets out more information about achieving a situation globally where all trials are registered and results reported. It is an achievement that will involve regulators and registries, clinical trial funders, universities and institutes, professional and learned societies and medical journals, patients and researchers.

This document is part of a continuing discussion which many different organisations are working on elaborating further over coming weeks and months.


..."



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Ben Goldacre's All Trials Registered | All Results Reported Campaign. (Original Post) HuckleB Oct 2013 OP
This would be an important step, not only for medical trials, but in every scientific field. (nt) enough Oct 2013 #1
So, you respect Ben Goldacre? I'm unfamiliar with his work, but have seen the name in the following. proverbialwisdom Oct 2013 #2
Just stop. HuckleB Oct 2013 #3
Read Goldacre's own words from his own Guardian article then. proverbialwisdom Oct 2013 #4
He sounds like he knows what he is talking about to me. nt bemildred Oct 2013 #5
I did. They were written in 2005. HuckleB Oct 2013 #6
Stop, I will, after reposting this essential update which you appear to have missed. proverbialwisdom Oct 2013 #8
Thus, Wakefield takes the blame for all the ugliness of that crap, deadly study. HuckleB Oct 2013 #9
No. Miss this? UK CryShame press release - 9 March 2013 proverbialwisdom Oct 2013 #10
And another pre-preliminary study. HuckleB Oct 2013 #11
I expressed no personal opinion, merely reposted legitimate research findings I saw reported at AOA. proverbialwisdom Dec 2013 #14
You're not clarify anything. HuckleB Dec 2013 #16
Ben Goldacre on Andrew Wakefield. HuckleB Oct 2013 #7
GMC FINDING OVERTURNED ON APPEAL IN 2012 FOR CO-DEFENDENT. Please see post #8 for details. nt proverbialwisdom Dec 2013 #12
Thanks for the kick! HuckleB Dec 2013 #13
On the contrary, head shake. proverbialwisdom Dec 2013 #15
Uh, "Age of Autism." HuckleB Dec 2013 #17
Sorry, but you are wrong as time will tell. nt proverbialwisdom Dec 2013 #18
"Time will tell." HuckleB Dec 2013 #19
that this isn't already law is another example of how corrupt our government is yurbud Dec 2013 #20
This is a world wide issue, and the history of research is quite complex. HuckleB Dec 2013 #21
research is complex. Industry footing the bill and deciding which studies see the light of day isn't yurbud Dec 2013 #22

proverbialwisdom

(4,959 posts)
2. So, you respect Ben Goldacre? I'm unfamiliar with his work, but have seen the name in the following.
Mon Oct 28, 2013, 06:47 PM
Oct 2013
http://www.ageofautism.com/2012/09/best-of-aofa-whats-behind-ben-goldacre.html

...For several years Ben Goldacre kept his distance from the Deer allegations against Wakefield, preferring to use the epidemiological literature to combat and deride concern about MMR and autism. In another ABSW award winning article Don’t dumb me down sponsored by Syngenta he wrote:

“people periodically come up to me and say, isn't it funny how that Wakefield MMR paper turned out to be Bad Science after all? And I say: no. The paper always was and still remains a perfectly good small case series report, but it was systematically misrepresented as being more than that by media that are incapable of interpreting and reporting scientific data.”

(HERE)


See: http://www.theguardian.com/science/2005/sep/08/badscience.research

Fear not, I won't post anything else on this thread, fyi.

HuckleB

(35,773 posts)
6. I did. They were written in 2005.
Tue Oct 29, 2013, 12:10 PM
Oct 2013

We know much more about the shenanigans that Wakefield pulled now.

Further, the value of a "small case studies series" is minimal. And that's how Goldacre defined the study even then. Later in the article, he points out that Wakefield was not challenged by the press as he should have been.

Thus, once again, we see that Age of Autism uses a quote that doesn't actually support them, out of context, and out of time.

STOP. You said you would.

proverbialwisdom

(4,959 posts)
8. Stop, I will, after reposting this essential update which you appear to have missed.
Tue Oct 29, 2013, 01:35 PM
Oct 2013

FYI, Professor John Walker-Smith is widely regarded as the co-founder of pediatric gastroenterology as an independent field with Dr. Allan Walker of Harvard Medical School.

http://www.guardian.co.uk/uk/feedarticle/10131156

MMR doctor wins High Court appeal

Press Association, Tuesday March 6 2012


Professor John Walker-Smith appealed against the General Medical Council's (GMC) determination that he was guilty of serious professional misconduct. His fight for his reputation was supported by the parents of many children with autism and bowel disease seen by him at the Royal Free Hospital, north London, up to his retirement in 2001.

Mr Justice Mitting, sitting at London's High Court, ruled the GMC decision "cannot stand". He quashed the finding of professional misconduct and the striking-off.

Calling for changes in the way GMC fitness to practise panel hearings are conducted in the future, the judge said of the flawed handling of Prof Walker-Smith's case: "It would be a misfortune if this were to happen again."

<...>

In a written ruling, the judge made it clear the judgment was the end of the case, and the GMC did not intend to appeal.


http://www.canaryparty.org/index.php/the-news/82-senior-author-of-mmr-paper-john-walker-smith-wins-appeal

Senior Author of MMR Paper, John Walker-Smith, Wins Appeal

Written by The Canary Party
Wednesday, 07 March 2012 16:13

FOR IMMEDIATE RELEASE: Wednesday, March 7, 2012


Dr. Andrew Wakefield’s co-author on controversial Lancet “MMR paper” completely exonerated of all charges of professional misconduct

World renowned pediatric gastroenterologist Prof. John Walker-Smith won his appeal today against the United Kingdom’s General Medical Council regulatory board that had ruled against both him and Andrew Wakefield for their roles in the 1998 Lancet MMR paper, which raised questions about a link to autism. The complete victory means that Walker-Smith has been returned to the status of a fully licensed physician in the UK, although he had already retired in 2001 — six years before the GMC trial even began.

Justice John Mitting ruled on the appeal by Walker-Smith, saying that the GMC “panel’s determination cannot stand. I therefore quash it.” He said that its conclusions were based on “inadequate and superficial reasoning and, in a number of instances, a wrong conclusion.” The verdict restores Walker-Smith’s name to the medical register and his reputation to the medical community. This conclusion is not surprising, as the GMC trial had no actual complainants, no harm came to the children who were studied, and parents supported Walker-Smith and Wakefield through the trial, reporting that their children had medically benefited from the treatment they received at the Royal Free Hospital.

While John Walker-Smith received funding to appeal the GMC decision from his insurance carrier, his co-author Andrew Wakefield did not — and was therefore unable to mount an appeal in the high court.

<...>

Today, almost 14 years after the paper was published, the high court determined that John Walker-Smith was innocent of the wrongdoing alleged by the GMC. Judge Mitting reported that the GMC, “on the basis of sensible instructions, does not invite me to remit it to a fresh Fitness to Practice panel for redetermination. The end result is that the finding of serious professional misconduct and the sanction of erasure are both quashed.”

More at link.

HuckleB

(35,773 posts)
9. Thus, Wakefield takes the blame for all the ugliness of that crap, deadly study.
Tue Oct 29, 2013, 03:00 PM
Oct 2013

Last edited Tue Oct 29, 2013, 04:47 PM - Edit history (1)

You seem to fail to understand that this is meaningless. The study was crap. It was very pre-preliminary, so even if it wasn't crap, it was basically meaningless. For you to continue with this line of nonsense is absolutely beyond the pale.

proverbialwisdom

(4,959 posts)
10. No. Miss this? UK CryShame press release - 9 March 2013
Tue Oct 29, 2013, 06:38 PM
Oct 2013
http://www.jabs.org.uk/

(Scroll down)

CryShame press release - 9 March 2013

Important new research ( http://www.plosone.org/article/info:doi/10.1371/journal.pone.0058058 ) reports similar findings to the work of Dr Andrew Wakefield in the 1998 Lancet and in subsequent paper in the early 2000s

Groundbreaking new research examines the molecular structure of inflammatory material taken from the bowels of autistic children. It compares the structure of diseased biopsies in the autistic children with biopsies from three groups of non-autistic children with Crohn’s disease, ulcerative colitis, and histologically normal (the controls).

Previous research confirmed the pathological and immunological make-up of biopsies of autistic children, but had not to date identified its specific molecular structure. Children with the four different conditions have been found to have similar findings of inflammation. But it was not clear if this was the same condition shared by all four groups; or if a distinct condition was specific to autistic children alone; or if indeed there was no disease in the autistic group. A molecular analysis of the genetic structure found in the inflamed bowel tissue of children in each group would provide initial answers to these questions.

To date government and medical scientists continue to deny an association between autism and bowel disease. In the UK there is currently no research into the association between autism and chronic bowel disease. This has been the predicament since the government and medical profession waged a campaign to discredit research from the Royal Free Hospital led by Dr Andrew Wakefield in 1998 and the early 2000s that first identified the presence of bowel disease in autistic children.

Following years of denial from government and the medical profession, new research published in the leading online journal PLOS ONE confirms the presence of intestinal disease in autistic children and supports reports from many parents of ongoing painful gastric problems in their autistic children.

The research studied bowel samples from 25 autistic, 8 Crohn's, 5 ulcerative colitis and 15 normal control children and found that inflammatory material obtained from the biopsies of autistic children had a distinct molecular structure that was different from the other three groups.

This is an important finding of the distinct genetic expression that has now been identified in autistic children as distinct from non-autistic children with Crohns, ulcerative colitis and normal bowels. It paves the way for future research into the specific molecular structure of the inflammation affecting autistic children and hopefully will lead to new interventions and treatment.

Background Notes

1. The first paper to bring to public attention the presence of bowel disease in autistic children was Wakefield AJ, (1998) 'Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children'.The Lancet published this paper in 1998 but subsequently retracted it in 2010 after the GMC found Dr Wakefield and Professor Walker-Smith guilty of serious professional misconduct.

2. Several former colleagues went on in the early 2000s to study the nature of the bowel disease in autistic children, focusing on the pathology of gut tissue and the presence of autoimmune features in the bowel (eg Furlano et al (2001) 'Colonic CD8 and ?? T-cell infiltration with epithelial damage in children with autism', Journal of Pediatrics, Vol. 138, 3).

3. The senior research leader of the Lancet and subsequent papers was Professor John Walker-Smith who in March 2012 had all the charges of professional misconduct made by the GMC quashed on appeal by Justice Mitting in the High Court.

4. Government Minister admits more needs to be done to research autism and bowel disease. Read letter here.



New research, Oct 16 2013, not unrelated to the broader questions: http://www.ncbi.nlm.nih.gov/pubmed/24147076

HuckleB

(35,773 posts)
11. And another pre-preliminary study.
Tue Oct 29, 2013, 06:49 PM
Oct 2013

You can't stop. You actually think this bad pre-preliminary nonsense offers something of value, in comparison to the vast number of large-scale studies that show MMR, and other vaccines to be safe.

When are you going to stop fooling yourself?

The story behind the MMR scare
The rightwing press's support for Wakefield's flawed research was based on its hostility towards the Labour government
http://www.theguardian.com/society/2013/apr/25/mmr-scare-analysis

proverbialwisdom

(4,959 posts)
14. I expressed no personal opinion, merely reposted legitimate research findings I saw reported at AOA.
Sat Dec 7, 2013, 04:07 PM
Dec 2013

The field is rapidly evolving. In part, the delayed Congressional VICP hearing postponed from December 4 will clarify matters.



http://www.scribd.com/doc/115393658/Andrew-Zimmerman

Andrew Zimmerman / Poling v HHS Exhibit 3

Published by Heather Rhodes White

In a second case Zimmerman was called to give his expert report on was Poling v. HHS. He revised his testimony, which was in complete contradiction from Cedillo v. HHS. His report to the Special Masters;

“The cause for regressive encephalopathy in Hannah (Poling) at age 19 months was underlying mitochondrial dysfunction, exacerbated by vaccine-induced fever and immune stimulation that exceeded metabolic energy reserves. This acute expenditure of metabolic reserves led to permanent irreversible brain injury. Thus, if not for this event, Hannah may have led a normal full productive life. Presently, I predict Hannah will have a normal lifespan but with significant lifelong disability."


HuckleB

(35,773 posts)
16. You're not clarify anything.
Sat Dec 7, 2013, 04:17 PM
Dec 2013

You're just spewing the classic, pointless Gish Gallop nonsense. You are working to promote scumbags. Stop.

HuckleB

(35,773 posts)
7. Ben Goldacre on Andrew Wakefield.
Tue Oct 29, 2013, 12:17 PM
Oct 2013
http://www.badscience.net/2010/01/the-wakefield-mmr-verdict/#more-1491

...

It’s certainly clear that Andrew Wakefield and his co-defendants failed to meet the high standards required of doctors in research. The GMC have found he was “misleading” “dishonest” and “irresponsible” in the way he described where the children in the 1998 paper came from, by implying that they were routine clinic referrals. As the GMC have also found, these children were subjected to a programme of unpleasant and invasive tests which were not performed in their own clinical interest, but rather for research purposes, and these tests were conducted without ethics committee approval.
These tests were hardly trivial: they included colonoscopy, where the child is sedated, and a long tube with a camera and a light passed through the anus and deep into the bowell; lumbar puncture, where a needle is placed into the spine to get cerebrospinal fluid; barium meals and more. It’s plainly undesirable for doctors to go around conducting tests like these on children for their own research interests without very careful external scrutiny.

...

Even if it had been immaculately well conducted – and it certainly wasn’t – Wakefield’s “case series report” of 12 children’s clinical anecdotes would never have justified the conclusion that MMR causes autism, despite what journalists claimed: it simply didn’t have big enough numbers to do so. But the media repeatedly reported the concerns of this one man, generally without giving methodological details of the research, either because they found it too complicated, inexplicably, or because to do so would have undermined their story.
...



------------------------------------------------------------

Thus, Age of Autism, as always is shown to be wrong, and despicably wrong.

HuckleB

(35,773 posts)
13. Thanks for the kick!
Sat Dec 7, 2013, 03:52 PM
Dec 2013

Post #8 is pointless, as the response showed.

Why do you continue to defend scumbags?

proverbialwisdom

(4,959 posts)
15. On the contrary, head shake.
Sat Dec 7, 2013, 04:15 PM
Dec 2013

I just saw this INVESTIGATIVE REPORT (September 24, 2013), http://www.ageofautism.com/2013/09/agent-orange-corporatism-government-coleen-boyle-and-autism.html

in the comments to the AOA post about VICP (below). Observe Dr. Boyle's role then and now. How's this gonna play out 30 years from now?

http://www.ageofautism.com/2013/11/postponing-vicp-hearing-who-is-afraid-and-of-what.html
COMMENT:
"...After reading Dawn Loughborough article ( http://www.ageofautism.com/2013/09/agent-orange-corporatism-government-coleen-boyle-and-autism.html ) describing how Colleen Boyle endorsed and disseminated junk science to deny US Veterans compensation for Agent Orange injury, I can understand why Boyle would not want to have to come face to face with an experienced federal prosecutor."

http://www.mcclatchydc.com/2013/07/22/197316/makers-of-agent-orange-followed.html#.Ue4MRY0sm0c
http://www.mcclatchydc.com/2013/07/22/197343/the-affects-of-agent-orange-in.html#storylink=cpy

Very sad.

HuckleB

(35,773 posts)
17. Uh, "Age of Autism."
Sat Dec 7, 2013, 04:18 PM
Dec 2013

How do you post from that site without vomiting. The scientific consensus is against you, no matter how much you Gish Gallop with bad sources.

HuckleB

(35,773 posts)
21. This is a world wide issue, and the history of research is quite complex.
Sat Dec 14, 2013, 08:29 PM
Dec 2013

Should something have been done about it long ago? Yes.

yurbud

(39,405 posts)
22. research is complex. Industry footing the bill and deciding which studies see the light of day isn't
Sat Dec 14, 2013, 09:18 PM
Dec 2013

Actually, this is a lot like the current state of education reform: those looking to make a buck get to call the shots, and cherry pick the evidence.

In the case of pharmaceuticals, the results could be far worse.

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