Democrats could actually end up with 54 US Senate seats after 2022 if WI,NC, and OH is included.

37)HI(Schatz-D)
38)NY(Schumer-D)
39)CA(Padilla-D)
40)VT(Welch-D)
41)CT(Blumenthal-D)
42)MD(Van Hollen-D)
43)OR(Wyden-D)
44)WA(Murray-D)
45)IL(Duckworth-D)
46)CO(Bennet-D)
47)AZ(Kelly-D)
48)PA(Fetterman-D)
49)NH(Hassan-D)
50)NV(Cortez Masto-D)
51)GA(Warnock-D)
52)WI(Barnes-D)
53)NC(Beasley-D)
54)OH(Ryan-D)

I did not include FL because Rubio is not that unpopular like Johnson is in WI. In NC and OH the Republican nominees are pretty weak.