PA is the only US Senate seat up for re-election in 2022 that will flip.

Anticipating on the Anti Democratic President Midterm wave and Democratic held US Senate seats up for re-election in 2022 lacking strong Republican challengers.
PA is a blue state that has a strong Democratic nominee and a weak Republican Nominee. The Republican candidates in the 2022 are not in the mainstream like Toomey-R just like in OH, Vance-R is not in the mainstream like Portman-R).

37)HI(Schatz-D)
38)NY(Schumer-D)
39)CA(Padilla-D)
40)MD(Van Hollen-D)
41)CT(Blumenthal-D)
42)VT(Welch-D)
43)OR(Wyden-D)
44)WA(Murray-D)
45)IL(Duckworth-D)
46)CO(Bennet-D)
47)NV(Cortez Masto-D)
48)NH(Hassan-D)
49)AZ(Kelly-D)
50)GA(Warnock-D)
51)PA(Fetterman-D)