Environment & Energy
Related: About this forumMCHM "Fact Sheet" Distributed More Than 1 Month After Spill; Says Nearly Nothing On Toxicity
EDIT
Dated Feb. 10, the fact sheet was not distributed to health professionals until more than a month after the leak was discovered, although Dr. Letitia Tierney, commissioner of the state Bureau of Public Health, requested it be made a few weeks ago, according to a spokeswoman for the Department of Health and Human Resources.
A prior fact sheet, sent the night of the leak, told health professionals that there was no information on the chemical's toxicity, but that skin irritation and vomiting were possible. That sheet was updated three days later to include additional symptoms, to warn of dehydration and to say that odor in the water was not an indicator that the water was toxic.
The Feb. 10, fact sheet is set up as a series of questions and answers. The authors ask themselves several simple "yes or no" questions that they do not answer quite so simply. "Are there any long term health concerns for my patients?" the fact sheet asks. As there are no long-term studies of the chemical, the answer is not definite.
"The short term exposures to MCHM and PPH in drinking water in West Virginia are not expected to result in long term health effects," the sheet answers.
EDIT
http://www.wvgazette.com/News/201402130129
DreamGypsy
(2,252 posts)...produced by the West Virginia Poison Center and the Mid-Atlantic Center for Children's Health and the Environment:
Charleston WV_Health Professionals Factsheet
It does follow the question/answer format described in the linked article.
More information about actual MCHM toxicity studies can be found on Wikipedia: 4-Methylcyclohexanemethanol - Health and safety
However, some of the data is based on studies of similar compounds and not MCHM specifically:
A WHO study of the toxicity of alicyclic primary alcohols and related alicyclic carbohydrates (of which MCHM is one type) found that LD-50 values for substances in this class generally "ranged from 890 to 5700 mg/kg bw for rats and > 1000 to 4000 mg/kg bw for mice, demonstrating that the oral acute toxicity of alicyclic primary alcohols, aldehydes, acids and related esters is low". The same study indicated that these alcohols are metabolized primarily to corresponding carboxylic acids, which in the case of MCHM is 4-methylcyclohexanecarboxylic acid (CAS 13064-83-0), a naphthenic acid. The toxicity and environmental properties of these naphthenic acids have been well studied recently due to their occurrence as a major contaminant in water used for extraction of oil from tar sands. Naphthenic acids have both acute and chronic toxicity to fish and other organisms. The methyl ester of this acid is also listed as one of the major impurities in the "crude MCHM" as supplied by Eastman.
The closely related compound cyclohexanedimethanol (CAS 105-08-8) exhibits low toxicity (3.5 g/kg) when fed orally to rats.
Cyclohexanemethanol (or cyclohexylmethanol, CHM, CAS 100-49-2), another closely related compound, which differs only in lacking a methyl substituent, has been found as a naturally occurring fusel alcohol in mango wine at concentrations of 1.45 mg/l, in which it is considered an aroma constituent. LASSO analysis predicts low to no activity on 40 receptors, similarly to MCHM.
KT2000
(20,583 posts)No one can be held liable for what has not been studied.