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Bill USA

(6,436 posts)
Fri Mar 7, 2014, 04:18 PM Mar 2014

Randomized, double-blind study: CoQ10 cuts all heart related causes of mortality by half.

http://www.sciencedaily.com/releases/2013/05/130525143852.htm

The Q-SYMBIO study (2) randomised 420 patients with severe heart failure (New York Heart Association (NYHA) Class III or IV) to CoQ10 or placebo and followed them for 2 years. The primary endpoint was time to first major adverse cardiovascular event (MACE) which included unplanned hospitalisation due to worsening of heart failure, cardiovascular death, urgent cardiac transplantation and mechanical circulatory support. Participating centres were in Denmark, Sweden, Austria, Slovakia, Poland, Hungary, India, Malaysia and Australia.

CoQ10 halved the risk of MACE, with 29 (14%) patients in the CoQ10 group reaching the primary endpoint compared to 55 (25%) patients in the placebo group (hazard ratio=2; p=0.003). CoQ10 also halved the risk of dying from all causes, which occurred in 18 (9%) patients in the CoQ10 group compared to 36 (17%) patients in the placebo group (hazard ratio=2.1; p=0.01).

CoQ10 treated patients had significantly lower cardiovascular mortality (p=0,02) and lower occurrence of hospitalisations for heart failure (p=0.05). There were fewer adverse events in the CoQ10 group compared to the placebo group (p=0.073).

Professor Mortensen said: "CoQ10 is the first medication to improve survival in chronic heart failure since ACE inhibitors and beta blockers more than a decade ago and should be added to standard heart failure therapy."
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Sarah Ibarruri

(21,043 posts)
3. Thanks for posting. I wonder if this is because some in the group were on statins?
Fri Mar 7, 2014, 05:24 PM
Mar 2014

I had a friend on statins and even his doctor told him he needed to take Co-Q-10 because statins diminishes the levels of Co-Q-10 in the body.

dickthegrouch

(3,174 posts)
5. I was unaware of the statin effect
Fri Mar 7, 2014, 06:20 PM
Mar 2014

But I've been taking Co-Q10 for years because of chronic dental problems and my Dentist's insistence that Co-Q10 was a necessity. The only question seems to be "How much Co-Q10 should one take?".

FWIW I'm using the Trader Joe's 90mg capsules twice a day as the least expensive solution I can find.

tanyev

(42,559 posts)
10. That's interesting.
Fri Mar 7, 2014, 07:30 PM
Mar 2014

My husband was put on statins after he was diagnosed with Type I diabetes and soon after noticed that he was accidentally biting his tongue much more often. It was our dentist that told him it was probably caused by the statin and that Co-Q10 would help. It did.

I just want to know why his diabetes doctor never mentioned Co-Q10.

Bill USA

(6,436 posts)
14. the main stream medical community has a very suspicous attitude about natural supplements. IN Europe
Thu Mar 20, 2014, 05:51 PM
Mar 2014

you won't find this bias. Consequently, it takes about 20 yrs for an effective natural supplement to be recognized by the medical community, which is steeped in a tradition that laboratory produced pharmaceuticals are the ONLY way to go.

I think the 20 yr period is in order to give the pharmaceutical companies time to come up with a synthetic analogue to the natural substance which they can sell you for 10 to 100 times more. LOL!

dickthegrouch

(3,174 posts)
12. Gingivitis or periodontal disease
Mon Mar 10, 2014, 12:43 PM
Mar 2014

Actually almost any inflammation of the gums will deplete Co-Q10 available to the heart, according to him.

Bill USA

(6,436 posts)
16. the reason CoQ10 reduces heart disease mortality is that bacteria in the blood stream cause
Thu Mar 20, 2014, 06:00 PM
Mar 2014

inflammation which impacts the whole cardiovascular system. The entree point for the bacteria is the gum line in the mouth. Taking CoQ10 knocks out these bacteria, reducing cardiovascular inflammation, improving heart health. This is also why they tell you flossing is important for heart health - helps hold down the proliferation of the bacteria along the gum line.

Please note, this statement has not been approved by the Pharmaceutical industry.




flamingdem

(39,313 posts)
17. I just started taking CoQ10 a couple of weeks ago
Thu Mar 20, 2014, 06:41 PM
Mar 2014

thanks, didn't realize it had to do with the gums.

SoapBox

(18,791 posts)
7. Wasn't CoQ10 one of the few vitamins/minerals, that is patented?
Fri Mar 7, 2014, 07:11 PM
Mar 2014

Hence why it's so expensive?

Or is that an old-wives tale?

Response to SoapBox (Reply #7)

Bill USA

(6,436 posts)
19. you can't patent a natural compound. You can patent a process for extracting it from it's source
Fri Apr 4, 2014, 05:42 PM
Apr 2014


plant. I believe CoQ10 is quite a bit cheaper than it used to be (like 30 yrs ago) because it's being sold in such enormous quantities now.


Response to Bill USA (Original post)

grasswire

(50,130 posts)
13. I've been a believer in CoQ10 for years now.
Tue Mar 18, 2014, 07:53 PM
Mar 2014

I take 400 mg/day.

And CoQ10 extended the life of my dear orange tabby cat by two years. He was diagnosed with CHF and hypertrophic cardiomyopathy. Poor prognosis. I started him on CoQ10 along with his Lasix, and he lived a good two more years.

The cardiologist I follow says he can not treat CAD without CoQ10 along with other supplements.

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