Welcome to DU! The truly grassroots left-of-center political community where regular people, not algorithms, drive the discussions and set the standards. Join the community: Create a free account Support DU (and get rid of ads!): Become a Star Member Latest Breaking News General Discussion The DU Lounge All Forums Issue Forums Culture Forums Alliance Forums Region Forums Support Forums Help & Search

unhappycamper

(60,364 posts)
Thu Jun 5, 2014, 08:12 AM Jun 2014

Single Dose of Antibiotic Found Effective in Quelling MRSA

http://www.nytimes.com/2014/06/05/health/single-dose-of-antibiotic-found-effective-in-quelling-mrsa.html?hpw&rref=us&_r=0



A highly magnified image of methicillin-resistant Staphylococcus aureus, or MRSA.

Single Dose of Antibiotic Found Effective in Quelling MRSA
By RONI CARYN RABIN
JUNE 4, 2014

A single infusion of an antibiotic can clear serious bacterial skin infections — including methicillin-resistant Staphylococcus aureus, or MRSA — just as effectively as the 10-day regimen now used to treat patients, researchers reported Wednesday.

Many patients do not finish the complicated treatment for these infections, which requires two infusions of antibiotics daily, often in a hospital. Such incomplete treatments may breed resistance to antibiotics in surviving bacteria. A single-dose therapy may make it easier to treat these dangerous infections, said the authors of the new study, published in The New England Journal of Medicine.

The study was led by researchers at Duke University and designed and funded by the Medicines Company, the maker of the antibiotic, oritavancin. The drug, to be sold as Orbactiv, may be approved by the Food and Drug Administration as early as August under a special fast-track process, the company said.

“This is a bit of a light at the end of a dismal tunnel in the development of new antibiotics,” said Dr. William Schaffner, an infectious disease specialist at Vanderbilt University, who was not involved in the new study.
13 replies = new reply since forum marked as read
Highlight: NoneDon't highlight anything 5 newestHighlight 5 most recent replies
Single Dose of Antibiotic Found Effective in Quelling MRSA (Original Post) unhappycamper Jun 2014 OP
That brings the new antibiotics that will kill MRSA to four Warpy Jun 2014 #1
Yeah, but we still have the docs to wash. They are the worst. WCLinolVir Jun 2014 #3
K&R. Glad to hear it. Overseas Jun 2014 #2
Or you can eat Manuka Honey DeSwiss Jun 2014 #4
How does an antibiotic knock out a cold? Orrex Jun 2014 #5
Um....No. jeff47 Jun 2014 #6
+1! n/t ColesCountyDem Jun 2014 #7
Not arguing with you, but my doctor's hospitalist (and internist) claimed she avoided deurbano Jun 2014 #8
There's a reason we started doing double-blind studies jeff47 Jun 2014 #9
Yes, I agree. deurbano Jun 2014 #11
Surgihoney deurbano Jun 2014 #10
I use it. It works. DeSwiss Jun 2014 #13
well--for NOW MisterP Jun 2014 #12

Warpy

(111,257 posts)
1. That brings the new antibiotics that will kill MRSA to four
Thu Jun 5, 2014, 08:23 AM
Jun 2014

three of which are "reserve" drugs, meaning it's still hard to get them in a lot of non teaching hospitals.

It's a semi synthetic, second generation Vancomycin, one of the few drugs that still kills MRSA. VRSA has now appeared in hospitals, so it's good research is ongoing.

Now if they'll only have SHOE COVERS for nurses caring for infected patients, maybe we can keep VRSA confined to hospitals, not out in the community, the way MRSA was allowed to spread.

That it works in a single infusion is excellent, Vancomycin often takes months for infections that have invaded the bones.



 

DeSwiss

(27,137 posts)
4. Or you can eat Manuka Honey
Thu Jun 5, 2014, 09:34 AM
Jun 2014
[font size=3]How Honey Curbs the MRSA Superbug[/font]

Ker Than
for National Geographic News
September 8, 2009



Bee on a manuka flower

A dark, bitter kind of honey can cripple infection-causing bacteria, including the highly virulent strain known as MRSA, and now researchers think they know how the honey fights the superbug.

Manuka honey is made when honeybees primarily consume the nectar of the manuka bush, a flowering plant native to Australia and New Zealand.

Researchers already knew that manuka honey has antibacterial properties, but why and how it works has been a mystery.

"Manuka honey has an extra [unidentified] component that isn't found in other honey, which gives it an extra kick," said study team member Rowena Jenkins of the University of Wales Institute, Cardiff.

More


- It knocks out colds, sore throats, etc.....

jeff47

(26,549 posts)
6. Um....No.
Thu Jun 5, 2014, 10:17 AM
Jun 2014

The test they describe is growing the bacteria in the presence of honey. If you eat honey, it doesn't get into your bloodstream. You digest it instead.

To replicate their experiment, you'd have to inject yourself with honey. That would be an extremely bad idea.

Also, this doesn't do a damn thing against colds and most sore throats, because they are caused by viruses, not bacteria.

It's really not a good idea to get your medical advice from National Geographic.

deurbano

(2,895 posts)
8. Not arguing with you, but my doctor's hospitalist (and internist) claimed she avoided
Thu Jun 5, 2014, 11:36 AM
Jun 2014

getting colds by eating a tsp full of Manuka honey every day. (Mind you, I started referring to her as Dr. Mengele-- though, not to her face--after some very unprofessional and even reckless decisions she made regarding my daughter's treatment, so I don't put a lot of faith in her medical advice.)

I got some of the honey for my daughter because she had esophagitis after having NG tubes down her throat while engaged in a constant hacking cough from a tumor crushing her esophagus. (Plus, she had terrible reflux, and she was also throwing up a lot of green bile for a time, after they replaced the NG feeding tube with a J-tube.) Online, I read about a study investigating the effectiveness of Manuka honey (taken orally) in addressing esophagitis pain caused by chemo/radiation for lung cancer. While not my daughter's specific situation (she had had chemo for lymphoma, but no radiation...so the esophagitis had a different cause), she gave it a try. I'm not sure if it was helpful, since she started the honey right when she was released from the hospital, so there were many other changes made...(This does not contradict your point about colds, obviously.)

http://www.cancer.gov/clinicaltrials/search/view?cdrid=690182&version=healthprofessional

Manuka Honey in Preventing Esophagitis-Related Pain in Patients Receiving Chemotherapy and Radiation Therapy For Lung Cancer

http://www.piedmonthospital.org/main/news-new/new-clinical-trial-studies-benefits-of-manuka-hone-1586.aspx

<<New clinical trial studies benefits of manuka honey in cancer patients’ pain management
Posted on 9/25/2013

Atlanta, Ga. (September 25, 2013) – The healing properties of honey have been recognized for thousands of years, dating back to its use by Egyptians in 1500 B.C. Today, doctors at Piedmont Atlanta Hospital are conducting a Radiation Therapy Oncology Group (RTOG) sponsored clinical trial to see if daily manuka honey consumption can delay or prevent radiation esophagitis-related pain during chemotherapy and radiation therapy for lung cancer.

“There is evidence to suggest honey in any form can reduce mucositis, a debilitating complication that occurs as a result of combining chemo and radiation therapy,” said Adam Nowlan, M.D. “Patients who develop mucositis often experience a lot of pain, making it difficult for them to speak, eat and continue uninterrupted treatment to fight the cancer.”

Patients participating in this trial are selected randomly to receive one of three treatments: liquid manuka honey, given four times a day; honey lozenges taken four times a day; or medications already on the market to help with pain associated with mucositis. To date, no trials of honey in the treatment or prevention of radiation-induced esophagitis have been reported, but three randomized trials of honey for the prevention of radiation mucositis have been published and serve as the basis of this study.

“Until we prove this, it is only a hypothesis,” said Dr. Nowlan. “But, we have a fair amount of evidence that shows manuka honey will be effective. In one of the randomized trials, 15% of the patients who received honey developed complications of mucositis as opposed to 65% those who did not. And, we have no reason to believe the honey will affect a patient’s ongoing treatment.”

Manuka honey is produced by bees which mainly feed on the manuka tree flower, native to New Zealand. It is distinctively darker than most other kinds of honey and is hailed for its antibacterial and healing properties over the world. Considered the standard medical honey, manuka honey has been proven to reduce inflammation and serve as an effective wound dressing. This study is only being conducted in the U.S. due to limited supply of manuka honey. >>

jeff47

(26,549 posts)
9. There's a reason we started doing double-blind studies
Thu Jun 5, 2014, 11:51 AM
Jun 2014

Humans are great at detecting patterns. Even when there is no pattern. So before we claim that a particular drug works, we do double-blind studies so that we can't impose our pattern-seeking on the study.

This:

my doctor's hospitalist (and internist) claimed she avoided getting colds by eating a tsp full of Manuka honey every day.

is the antithesis of a double-blind study. She'd probably detect the same results with eating a tsp of damn near anything, because she's seeking the pattern. "I eat this, I don't get sick." Therefore, every instance where she doesn't get the office cold is a victory for her honey habit. Every instance where she does get the office cold is just bad luck, and not proof of anything regarding her honey habit. And since it's really unlikely she's keeping detailed records, those victories stick in her mind more than the failures.

As for this:
read about a study investigating the effectiveness of Manuka honey (taken orally) in addressing esophagitis pain caused by chemo/radiation for lung cancer.

It would actually be possible for the honey to do something, because the honey has a chance of getting in contact with the relevant area. But that says nothing about colds or MRSA infections. To treat those, the honey would have to survive the digestive tract and make it into the bloodstream in order to reach the infection.

deurbano

(2,895 posts)
10. Surgihoney
Thu Jun 5, 2014, 11:55 AM
Jun 2014

I became interested in the "healing powers of honey" when a honey dressing was very effective in helping to heal the Stage 4 pressure ulcer my daughter (who is disabled, but had never had a pressure ulcer of any kind before) developed during a recent hospital stay. (That ulcer, especially Stage 4, should never have happened, but that's another story...) In addition to healing her pressure ulcer, there was some evidence that Maunka honey (in particular) might be helpful in treating the esophagitis she had also developed during her stay. (See Post #8)

I don't know if the Surgihoney is just PR hype, but it does sound promising:

http://www.theguardian.com/global-development/poverty-matters/2014/jan/01/surgihoney-treatment-infected-wounds

<<The healing powers of honey have been known about for thousands of years. But Surgihoney, whose natural antibacterial properties have been boosted, is proving highly effective at treating infected wounds and superbugs.

The honey is believed to work by killing the bugs, removing dead tissue and pus, and then providing a moisture barrier as well as local nutrition. Honey contains vitamins, minerals, enzymes and sugars – all of which help in the healing of wounds.

Manuka is generally regarded as the most potent honey, but it relies upon nectar from a particular tree in New Zealand, limiting its supply. That's precisely the problem which has been solved by the developers of Surgihoney. They have created a product that can be made from organic honey from any floral source. They hope it will ultimately become a global wound-care product that will improve lives in poorer countries.

Lead researcher Dr Matthew Dryden, an NHS consultant microbiologist, is optimistic that the sterile, medical honey can revolutionise wound care around the world, reduce the use of antibiotics and provide an alternative to harsh chemical antiseptics. Surgihoney speeds the healing of hard-to-treat leg and foot ulcers, pressure sores, trauma injuries and infected surgical wounds, according to the research. Potential benefits include less pain and fewer amputations...


Surgihoney can even tackle wounds infected with strains of bacteria resistant to antibiotics, he says, including MRSA, E coli and pseudomonas. He describes honey as "turbo-boosted".... Dryden was lead author in a study that concludes: "As a wound treatment in the tropics, [Surgihoney] is an ideal, low-technology solution which is easily stored, applied and ought to be cost-effective." And unlike more sophisticated medicines, it does not need to be refrigerated....>>

 

DeSwiss

(27,137 posts)
13. I use it. It works.
Thu Jun 5, 2014, 06:40 PM
Jun 2014

Another recent discovery I've made that helps me stave off inflammation and infection is Astragalus Root:

Research

Biotechnology firms are working on deriving a telomerase activator from Astragalus. The chemical constituent cycloastragenol (also called TAT2) is being studied to help combat HIV, as well as infections associated with chronic diseases or aging. However, the National Institutes of Health states: "The evidence for using astragalus for any health condition is limited. High-quality clinical trials (studies in people) are generally lacking. There is some preliminary evidence to suggest that astragalus, either alone or in combination with other herbs, may have potential benefits for the immune system, heart, and liver, and as an adjunctive therapy for cancer".

Research at the UCLA AIDS Institute focused on the function of cycloastragenol in the aging process of immune cells, and its effects on the cells' response to viral infections. It appears to increase the production of telomerase, an enzyme that mediates the replacement of short bits of DNA known as telomeres, which play a key role in cell replication, including in cancer processes.
link
Latest Discussions»Issue Forums»Health»Single Dose of Antibiotic...