Welcome to DU!
The truly grassroots left-of-center political community where regular people, not algorithms, drive the discussions and set the standards.
Join the community:
Create a free account
Support DU (and get rid of ads!):
Become a Star Member
Latest Breaking News
General Discussion
The DU Lounge
All Forums
Issue Forums
Culture Forums
Alliance Forums
Region Forums
Support Forums
Help & Search
(Mouse study suggests) Repeated Courses of Antibiotics May Profoundly Alter Children’s Development
http://nyulangone.org/press-releases/repeated-courses-of-antibiotics-may-profoundly-alter-childrens-development[font face=Serif][font size=5]Repeated Courses of Antibiotics May Profoundly Alter Children’s Development[/font]
[font size=4]New Study in Mice from NYU Langone Medical Center Finds Multiple, Long-Lasting Effects after Several Courses of Antibiotics Commonly Used in Children[/font]
July 1, 2015 (9:00AM)
[font size=3]A new animal study from NYU Langone Medical Center researchers adds to growing evidence that multiple courses of commonly used antibiotics may have a significant impact on children’s development.
In the study, to be published online June 30 by the journal Nature Communications, female mice treated with two classes of widely used childhood antibiotics gained more weight and developed larger bones than untreated mice. Both of the antibiotics also disrupted the gut microbiome, the trillions of microbes that inhabit the intestinal tract.
Overall, the mice received three short courses of amoxicillin, a broad-spectrum antibiotic, tylosin, which isn’t used in children but represents another common antibiotic class called the macrolides, which is increasingly popular in pediatrics, or a mixture of both drugs. To mimic the effects of pediatric antibiotic use, the researchers gave the animals the same number of prescriptions and the same therapeutic dose that the average child receives in the first two years of life. A control group of mice received no drugs at all.
Martin Blaser, MD, the Muriel G. and George W. Singer Professor of Translational Medicine, director of the NYU Human Microbiome Program at NYU School of Medicine, and the study’s senior author, cautions that the study was limited to mice. Even so, he says the results agree with multiple other studies pointing toward significant effects on children exposed to antibiotics early in life, and he notes that the cumulative data could help shape guidelines governing the duration and type of pediatric prescriptions. “We have been using antibiotics as if there was no biological cost,” says Dr. Blaser. The average child in the United States, he says, receives 10 courses of the drugs by the age of 10.
…[/font][/font]
(Video at link.)[font size=4]New Study in Mice from NYU Langone Medical Center Finds Multiple, Long-Lasting Effects after Several Courses of Antibiotics Commonly Used in Children[/font]
July 1, 2015 (9:00AM)
[font size=3]A new animal study from NYU Langone Medical Center researchers adds to growing evidence that multiple courses of commonly used antibiotics may have a significant impact on children’s development.
In the study, to be published online June 30 by the journal Nature Communications, female mice treated with two classes of widely used childhood antibiotics gained more weight and developed larger bones than untreated mice. Both of the antibiotics also disrupted the gut microbiome, the trillions of microbes that inhabit the intestinal tract.
Overall, the mice received three short courses of amoxicillin, a broad-spectrum antibiotic, tylosin, which isn’t used in children but represents another common antibiotic class called the macrolides, which is increasingly popular in pediatrics, or a mixture of both drugs. To mimic the effects of pediatric antibiotic use, the researchers gave the animals the same number of prescriptions and the same therapeutic dose that the average child receives in the first two years of life. A control group of mice received no drugs at all.
Martin Blaser, MD, the Muriel G. and George W. Singer Professor of Translational Medicine, director of the NYU Human Microbiome Program at NYU School of Medicine, and the study’s senior author, cautions that the study was limited to mice. Even so, he says the results agree with multiple other studies pointing toward significant effects on children exposed to antibiotics early in life, and he notes that the cumulative data could help shape guidelines governing the duration and type of pediatric prescriptions. “We have been using antibiotics as if there was no biological cost,” says Dr. Blaser. The average child in the United States, he says, receives 10 courses of the drugs by the age of 10.
…[/font][/font]
2 replies
= new reply since forum marked as read
= new reply since forum marked as read
…
Overall, the mice received three short courses of amoxicillin, a broad-spectrum antibiotic, tylosin, which isn’t used in children but represents another common antibiotic class called the macrolides, which is increasingly popular in pediatrics, or a mixture of both drugs. To mimic the effects of pediatric antibiotic use, the researchers gave the animals the same number of prescriptions and the same therapeutic dose that the average child receives in the first two years of life. A control group of mice received no drugs at all.
…
Overall, the mice received three short courses of amoxicillin, a broad-spectrum antibiotic, tylosin, which isn’t used in children but represents another common antibiotic class called the macrolides, which is increasingly popular in pediatrics, or a mixture of both drugs. To mimic the effects of pediatric antibiotic use, the researchers gave the animals the same number of prescriptions and the same therapeutic dose that the average child receives in the first two years of life. A control group of mice received no drugs at all.
…
They used:
- Amoxicillin (which is used in children)
- Tylosin (which is added to animal feed.)
- A combination of both
- A “control group” which received neither.
This is from the study:
