Health
Related: About this forumJohns Hopkins researchers say they've unlocked key to cancer metastasis.
Hasini Jayatilaka was a sophomore at the Johns Hopkins University working in a lab studying cancer cells when she noticed that when the cells become too densely packed, some would break off and start spreading.
She wasn't sure what to make of it, until she attended an academic conference and heard a speaker talking about bacterial cells behaving the same way. Yet when she went through the academic literature to see if anyone had written about similar behavior in cancer cells, she found nothing.
Seven years later, the theory Jayatilaka developed early in college is now a bona fide discovery that offers significant promise for cancer treatment.
Jayatilaka and a team at Johns Hopkins discovered the biochemical mechanism that tells cancer cells to break off from the primary tumor and spread throughout the body, a process called metastasis. Some 90 percent of cancer deaths are caused when cancer metastasizes. The team also found that two existing, FDA-approved drugs can slow metastasis significantly.
More at:
http://www.baltimoresun.com/health/bs-hs-cancer-trigger-20170625-story.html
dixiegrrrrl
(60,010 posts)duhneece
(4,112 posts)At least that is my current experience at my ripe age of 66!
So I, too, wish to express gratitude.
dixiegrrrrl
(60,010 posts)Meanwhile the CDC was saying there is not much need for women over 70 to get annual mammograms.
I am here to tell you...ignore the CDC.
duhneece
(4,112 posts)I'll get me off to that place where they sqush my boobs...it's not even painful to me, just weird. I'm 66 and missed the past couple of years my primary doc ordered one for me. I promise.
dixiegrrrrl
(60,010 posts)And I mean to ask them, will they bill me half rate considering I have only boob now?
duhneece
(4,112 posts)told me she spent the night before figuring out the money she'd save on toilet paper after her colonoscopy.
SonofDonald
(2,050 posts)I lost my little sister and her husband four years apart to the day, my two best friends.
Their children had to deal with the loss of both Parents, both had almost beat the cancer when it took their lives, it was heartbreaking to say the least.
If it's true and a cure is found along these lines this woman should get the Nobel Prize.
Hands down.
ghostsinthemachine
(3,569 posts)I'll be interested to see the application and how long until approved and becomes a standard treatment. And how it would be used.
Thanks for posting. I am a recent cancer survivor that is now cancer free, but I wonder of recurrence.
The Wielding Truth
(11,415 posts)retrowire
(10,345 posts)Changes nothing for us. Don't care.
The Wielding Truth
(11,415 posts)medicine.
retrowire
(10,345 posts)Akamai
(1,779 posts)I'm going to lose my insurance because I can't afford the Trumpcare premiums. I'm trying to come to grips with the fact that all of this will be out of reach for me. The millions of us -- if we find a lump or a spot, too bad. We won't be able to do a thing about it. So it's exciting science, but too emotionally painful to really contemplate.
mbusby
(823 posts)...sounds menacing and foreign. Quick... deport her.
C Moon
(12,213 posts)Rollo
(2,559 posts)I hope this becomes a routine treatment
mountain grammy
(26,621 posts)classykaren
(769 posts)I can't believe it.
SammyWinstonJack
(44,130 posts)PatSeg
(47,430 posts)Big bucks for the pharmaceutical industry in treatment. Hopefully, no one will try to make a huge profit off this discovery. Medicine should be about saving lives, not making money for shareholders.
This is an exciting breakthrough though!
Ghost Dog
(16,881 posts)for their shareholders.
Medical corporations are no exception. The same applies to corporations that by omission or commission damage the environment as well as society.
Can laws be changed to also impose social and environmental responsibilities on corporations, obligations to ensure that maximum social and environmental benefits also accrue?
Is there something inadequate, not fit for purpose, about the way "profit" is calculated within contemporary financial systems, when so many negative consequences are classed as 'externalities' and not taken into account at all?
PatSeg
(47,430 posts)when there were laws and strict ethics regarding anything related to medicine. Pharmaceutical companies, hospitals, and doctors were not allowed to advertise. Medicine was considered a service, not a commodity. At times, it seemed it bit restrictive, but now I can see why.
pangaia
(24,324 posts)dixiegrrrrl
(60,010 posts)I take an anti-cancer drug which lists for 800.00 to 1600.00 a month, for the generic version, no less,
depending on which stores you look at, and a week later those prices will, and have, changed.
Luckily, there are ways for the non-insured to get an extremely cheap price, but few people know about it.
Insurance companies do not seem to be challenging the insanely high prices of drugs and doctor bills.
Orrex
(63,212 posts)Funny that both of my parents became cancer-free after treatment, so I guess Big Pharma suspended its evil profit-seeking campaign just long enough to cure them, for some reason.
My father, in fact, was successfully treated for two different cancers years apart. What could possibly account for this two-person shift in the malevolent agenda of the ravenous pharmaceutical machine?
Quixote1818
(28,936 posts)and you will still have to treat people even if they can find a better way to treat cancer. People making money off of cancer treatment also want to find a cure because they themselves don't want to get cancer and die. There is plenty of motivation to find a cure.
Cancer is EXTREMELY hard to cure for many reasons but mostly because they are our own cells not an outside pathogen. Every person's body responds to treatment differently. This is just one step to combat cancer and it has a long ways to go. Thousands of people are working their ass off to find a cure. Many of those people doing the work have lot loved ones along they way from cancer.
WinstonSmith4740
(3,056 posts)I lost my husband seven years ago, and my brother-in-law last year. Nothing would have helped my husband...his was genetic. But my brother-in-law was a different story...he would have benefited from the clinical trials. But it is a breakthrough, and a welcome one. I'm a little dismayed by some of the comments here. Just this once, can we put politics aside? ALL new treatments, regardless of the condition they're treating, are expensive and not available to all at first. But this will save lives, maybe not as many as we would want in the short term, but down the road. This is too late for both my husband and brother-in-law, but it can benefit my nephews and nieces...as well as your children. Can we just celebrate the breakthrough?
Peace.
athena
(4,187 posts)There is nothing to be gained by attacking a researcher for having discovered something. (I suspect what bothers some people is that it's a female researcher with a foreign name. An all-American male researcher would have been celebrated for something like this, but no one likes it when a woman shows she's smarter than all the men out there.)
I'm sick of the conspiracy theories. It's not easy to find a cure for diseases like cancer and Alzheimer's. It's not because there is some sort of conspiracy that a cure doesn't yet exist. These are very complicated diseases, and research often doesn't progress in a linear way.
If people don't like the medical industrial complex, they should fight for single-payer healthcare. Attacking a university researcher for being curious and observant and brilliant is the wrong response.
iluvtennis
(19,858 posts)Duppers
(28,120 posts)The treatment will become afford.
Partial to JHU folks. They saved my hubs from cancer and my son has two degrees from JHU.
Marie Marie
(9,999 posts)I had a doctor once tell me: "The only reason everybody doesn't die of cancer is that they die of something else first." No one is immune from cancer.
Me.
(35,454 posts)and as a bonus...a girl discovered it
broadcaster90210
(333 posts)We won't have the insurance to pay for it.
jimlup
(7,968 posts)With science I've learned to wait for confirmation... so here's to hoping!
DFW
(54,380 posts)The article said the encouraging results were in mice, not humans, and it didn't say whether the two drugs that showed effectiveness were cheap to produce, or cost a lot, and therefore would not be easy to mass-produce. My father was treated for pancreatic cancer at Johns Hopkins. They did their level best, but they couldn't save him.
downeastdaniel
(497 posts)rtracey
(2,062 posts)Working with many of these phenomenal people is such a pleasure. I just celebrated 30 years at Johns Hopkins, and every one of them has been fantastic.
locks
(2,012 posts)and our eternal gratitude to those who have worked so hard to try to lessen the ravages of cancer which affect us all. I have recently suffered a terrible loss; it is so difficult when we think a loved one might have been saved by more research or a different treatment. But one of my real regrets is that big-profit Pharma is allowed to advertise to cancer patients and doctors in ways that are cruel and dishonest. With cancer we want to try anything that might work and all patients should have options, but every patient has the right to know exactlywhat their treatment may entail, including pain and cost and time. We can be thankful that advances like immunotherapy have saved some lives but how many really know what "lengthening your life" means if you have lung cancer or how severe the side effects of a treatment for metastasized breast cancer may be.
I recommend the new book, The Bright Hour, by Nina Riggs who died of cancer this year at age 39.
question everything
(47,479 posts)The team then tested two drugs known to work on the Interleukin receptors to see if they would block or slow metastasis in mice. They found that using the two drugs together would block the signals from the Interleukin proteins that told the cancer cells to break off and spread, slowing though not completely stopping metastasis.
The drugs the team used were Tocilizumab, a rheumatoid arthritis treatment, and Reparixin, which is being evaluated for cancer treatment.
The drugs bind to the Interleukin receptors and block their signals, slowing metastasis.
Though metastasis was not completely stopped, Jayatilaka said, the mice given the drug cocktail fared well and survived through the experiment. She said adding another, yet-to-be-determined drug or tweaking the dose might stop metastasis entirely.