HIV completely removed from mice in groundbreaking study

https://www.dw.com/en/hiv-completely-removed-from-mice-in-groundbreaking-study/a-49467736

HIV completely removed from mice in groundbreaking study

Date 04.07.2019
Author Rebecca Staudenmaier

Mice infected with HIV ended up virus-free after US researchers were able to remove it from their cells for the first time, according to a study published in the journal Nature Communicationsthis week.

Researchers at Temple University in Pennsylvania and the University of Nebraska developed a two-step approach to eliminate the AIDS-causing virus from the genomes of the mice.

In the first part of the treatment, a special slow-release form of antiretroviral medication (known as LASER ART) was administered. The drugs halt the progress of HIV by targeting the virus' lifecycle, but they do not eliminate it.

In the second part, scientists used CRISPR-Cas9 gene editing to remove HIV DNA from infected cells.

Over a third of the mice examined in the study had no signs of HIV DNA in their cells following the combination treatment.

Dr. Kamel Khalili, who led the research team at Temple University, said that the main takeaway from the study is that when the two methods are used together, they can be used "to produce a cure for HIV infection."

"We now have a clear path to move ahead to trials in non-human primates and possibly clinical trials in human patients within the year," Khalili said in a statement.
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