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Celebration

(15,812 posts)
Thu Jan 19, 2012, 06:37 PM Jan 2012

Deadly E. Coli Toxin Can Be Stopped With Manganese, Study Says

http://www.businessweek.com/news/2012-01-19/deadly-e-coli-toxin-can-be-stopped-with-manganese-study-says.html

Jan. 19 (Bloomberg) -- A deadly toxin produced by certain kinds of E. coli, including those that caused an outbreak in Europe last year, can be combated using the element manganese, according to research that may lead to an inexpensive treatment for infections.

Manganese, commonly found in nature, protected cells against as much as 4,000 times the amount of that toxin required to cause death in the lab, according to scientists in the journal Science. In a study, mice dosed with manganese were resistant to the poison.

That toxin, called Shiga, caused the severe diarrhea and kidney damage seen in the European outbreak. Antibiotics aren’t effective and may make the poison worse by causing the bacteria to burst open, releasing more Shiga and making patients sicker. There is no treatment for the infections, which sicken 150 million worldwide and kill more than 1 million each year, according to the study authors.
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Deadly E. Coli Toxin Can Be Stopped With Manganese, Study Says (Original Post) Celebration Jan 2012 OP
Top 10 Foods Highest in Manganese tabatha Jan 2012 #1
I love it when they explain HOW it works! Chemisse Jan 2012 #2

Chemisse

(30,813 posts)
2. I love it when they explain HOW it works!
Thu Jan 19, 2012, 08:44 PM
Jan 2012
Manganese protects cells by blocking the path the Shiga toxin takes to shut down the cell. Shiga avoids the cell’s lysosomes, which would render it harmless, by riding on a protein called GPP130. The presence of manganese causes GPP130 to go to the lysosomes, leading Shiga there as well.



Really interesting!
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