Even the very references to a "Christian Middle East" conceal an ugly animosity. Without Islam, the peoples of the Middle East would have remained as they were at the birth of Islam — mostly adherents of Eastern Orthodox Christianity. But it’s easy to forget that one of history’s most enduring, virulent, and bitter religious controversies was that between the Catholic Church in Rome and Eastern Orthodox Christianity in Constantinople — a rancor that persists still today. Eastern Orthodox Christians never forgot or forgave the sacking of Christian Constantinople by Western Crusaders in 1204. Nearly 800 years later, in 1999, Pope John Paul II sought to take a few small steps to heal the breach in the first visit of a Catholic pope to the Orthodox world in a thousand years. It was a start, but friction between East and West in a Christian Middle East would have remained much as it is today. Take Greece, for example: The Orthodox cause has been a powerful driver behind nationalism and anti-Western feeling there, and anti-Western passions in Greek politics as little as a decade ago echoed the same suspicions and virulent views of the West that we hear from many Islamist leaders today.

The culture of the Orthodox Church differs sharply from the Western post-Enlightenment ethos, which emphasizes secularism, capitalism, and the primacy of the individual. It still maintains residual fears about the West that parallel in many ways current Muslim insecurities: fears of Western missionary proselytism, a tendency to perceive religion as a key vehicle for the protection and preservation of their own communities and culture, and a suspicion of the "corrupted" and imperial character of the West. Indeed, in an Orthodox Christian Middle East, Moscow would enjoy special influence, even today, as the last major center of Eastern Orthodoxy. The Orthodox world would have remained a key geopolitical arena of East-West rivalry in the Cold War. Samuel Huntington, after all, included the Orthodox Christian world among several civilizations embroiled in a cultural clash with the West.