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nitpicker

(7,153 posts)
Fri Mar 3, 2017, 07:42 AM Mar 2017

DNA clues to why woolly mammoth died out

http://www.bbc.com/news/science-environment-39142941

DNA clues to why woolly mammoth died out

By Helen Briggs
BBC News

2 hours ago

From the section Science & Environment

The last woolly mammoths to walk the Earth were so wracked with genetic disease that they lost their sense of smell, shunned company, and had a strange shiny coat. That's the verdict of scientists who have analysed ancient DNA of the extinct animals for mutations. The studies suggest the last mammoths died out after their DNA became riddled with errors.

The knowledge could inform conservation efforts for living animals. There are fewer than 100 Asiatic cheetahs left in the wild, while the remaining mountain gorilla population is estimated at about 300. The numbers are similar to those of the last woolly mammoths living on Wrangel Island in the Arctic Ocean around 4,000 years ago.

Dr Rebekah Rogers of the University of California, Berkeley, who led the research, said the mammoths' genomes "were falling apart right before they went extinct". This, she said, was the first case of "genomic meltdown" in a single species.
(snip)

The researchers analysed genetic mutations found in the ancient DNA of a mammoth from 4,000 years ago. They used the DNA of a mammoth that lived about 45,000 years ago, when populations were much larger, as a comparison.
(snip)

"There was this huge excess of what looked like bad mutations in the genome of the mammoth from this island," said Dr Rogers. "We found these bad mutations were accumulating in the mammoth genome right before they went extinct."
(snip)
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truebluegreen

(9,033 posts)
2. I'm guessing inbreeding was the final straw,
Fri Mar 3, 2017, 08:14 AM
Mar 2017

climate and predation by man the driving force. Just a guess.

 

truebluegreen

(9,033 posts)
4. Years ago we had some involvement
Fri Mar 3, 2017, 10:55 AM
Mar 2017

with the Peregrine Fund and their breeding program to recover (breed and release) a viable population of peregrines in the US.

They had very few to begin with as the birds had died out in the wild and their only breeding stock was provided by falconers (no one had tried to breed them before so the whole thing was a long-shot at best).

They succeeded partly because of their meticulous tracking of bloodlines, to avoid just the sort of issues that develop in a limited gene pool.

lastlib

(23,248 posts)
7. So the GOPee IS doomed for extinction..........
Fri Mar 3, 2017, 11:01 PM
Mar 2017
. . . . . . . . . . .

. . . . . . . . . . .

. . . . . . . . . . .

. . . . . . . . . . .

Happy Days are Here AGAIN!

Brother Buzz

(36,444 posts)
6. If that was the case, wouldn't the DNA of a mammoth that lived about 45,000 years ago
Fri Mar 3, 2017, 03:32 PM
Mar 2017

show more errors then the 4,000 year old DNA?

Nitram

(22,822 posts)
8. I don't know. Wouldn't it depend on how well it was preserved in the fist place?
Sat Mar 4, 2017, 06:23 PM
Mar 2017

I assume that if the animal quickly froze in the ice and was covered in snow it would be better preserved than if it took a while to freeze and it was not quickly buried in the snow and ice. This is not my field of expertise. I'm just asking if anyone out there knows the answer.

 

Thor_MN

(11,843 posts)
9. No. The DNA does break down, but they essentially splice the sequence back together from many copies
Sun Mar 5, 2017, 10:07 AM
Mar 2017

Imagine that you had millions of copies of, say, Casablanca on film. They were all randomly chopped up. By lining up sections of film with matching frames from other copies, you can eventually get a copy of every frame, in order. One segment has frames 79 through 130, another frames 110 through 156. By matching frames 110 through 130, you now know frames 79 through 156. Now, film is much easier as every frame is unique and DNA only has 4 "frames", but it is essentially the same concept match the sequence of the fragments with the sequence of other fragments and you get the entire work back. Every cell had a copy of the DNA.

A mutation would be Rick saying "Of all the gin joints, have Paris looking at you, kid." or the Capt saying "Round up all the usual gambling in this establishment."

There's a difference between a mutation and degradation.

Javaman

(62,530 posts)
10. "lost their sense of smell, shunned company, and had a strange shiny coat"
Mon Mar 6, 2017, 10:42 AM
Mar 2017

so the basically turned in howard hughes...

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