Science
Related: About this forumMagic mushroom compound might treat depression by reviving emotional responsiveness in the brain
From http://www.psypost.org/2018/01/magic-mushroom
ERIC W. DOLAN January 5, 2018
New research suggests that psilocybin-assisted therapy helps alleviate treatment-resistant depression by reviving emotional responsiveness in the brain.
Psilocybin is the primary mind-altering substance in psychedelic magic mushrooms. The drug can profoundly alter the way a person experiences the world by producing changes in mood, sensory perception, time perception, and sense of self.
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From https://www.sciencedirect.com/science/article/pii/S0028390817306391
Psilocybin with psychological support was used successfully to treat depression.
Amygdala responses to fearful faces were increased one day after psilocybin session.
Increased amygdala responses predicted positive clinical outcomes.
Psilocybin assisted therapy treats depression by reviving emotional responsiveness.
Abstract
Recent evidence indicates that psilocybin with psychological support may be effective for treating depression. Some studies have found that patients with depression show heightened amygdala responses to fearful faces and there is reliable evidence that treatment with SSRIs attenuates amygdala responses (Ma, 2015). We hypothesised that amygdala responses to emotional faces would be altered post-treatment with psilocybin. In this open-label study, 20 individuals diagnosed with moderate to severe, treatment-resistant depression, underwent two separate dosing sessions with psilocybin. Psychological support was provided before, during and after these sessions and 19 completed fMRI scans one week prior to the first session and one day after the second and last. Neutral, fearful and happy faces were presented in the scanner and analyses focused on the amygdala. Group results revealed rapid and enduring improvements in depressive symptoms post psilocybin. Increased responses to fearful and happy faces were observed in the right amygdala post-treatment, and right amygdala increases to fearful versus neutral faces were predictive of clinical improvements at 1-week. Psilocybin with psychological support was associated with increased amygdala responses to emotional stimuli, an opposite effect to previous findings with SSRIs. This suggests fundamental differences in these treatments therapeutic actions, with SSRIs mitigating negative emotions and psilocybin allowing patients to confront and work through them. Based on the present results, we propose that psilocybin with psychological support is a treatment approach that potentially revives emotional responsiveness in depression, enabling patients to reconnect with their emotions.
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More at links.
lastlib
(23,237 posts)When the men on the chessboard
Get up and tell you where to go
And you've just had some kind of mushroom
And your mind is moving low.
Go ask Alice, I think she'll know.
. . . .
sl8
(13,779 posts)gvstn
(2,805 posts)I've read so many articles. Why don't they get this on the market already?
I also want to know if the treatment they are using (isolating the effective chemical) eliminates the "trip" part of taking mushrooms or if that would be an effect of the pharmaceutical version. This never seems to be mentioned.
sl8
(13,779 posts)It is important to emphasize that psilocybin-assisted therapy is a model in which the patient is undergoing a deep psychological process in one or few psychedelic sessions, in which he might have an intense cathartic experience, or peak experience, Roseman explained.
Patients receive a dose of psilocybin in a controlled setting while professionals are on hand to provide them with psychological support. The patients also typically receive counseling before and after each session, to help them prepare for and integrate their psychedelic experience.
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Also, the study references the "high" that the patients experience.
gvstn
(2,805 posts)I must say that I did mushrooms when I was much younger and I noticed a good effect on my depressed personality. Just felt more in tune with the world and people around me. I can't say how long the effect lasted but I would definitely say the 6 mos. range stated in the article is pushing it.
I really would like to try them again and could probably find someone to get them. I just would rather not experience the "trip" at my age. Oh well. I wait to see if they offer any trial sessions in my area.