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Science
Related: About this forumUS Immigration Westernizes the Human Gut Microbiome
From https://www.cell.com/cell/fulltext/S0092-8674(18)31382-5
US Immigration Westernizes the Human Gut Microbiome
Pajau Vangay, Abigail J. Johnson, Tonya L. Ward, Gabriel A. Al-Ghalith, Robin R. Shields-Cutler, Benjamin M. Hillmann, Sarah K. Lucas, Lalit K. Beura, Emily A. Thompson, Lisa M. Till, Rodolfo Batres, Bwei Paw, Shannon L. Pergament, Pimpanitta Saenyaku, Mary Xiong, Austin D. Kim, Grant Kim, David Masopust, Eric C. Martens, Chaisiri Angkurawaranon, Rose McGready, Purna C. Kashyap, Kathleen A. Culhane-Pera, Dan Knights
Published: November 1, 2018 DOI:https://doi.org/10.1016/j.cell.2018.10.029
Highlights
US immigration is associated with loss of gut microbiome diversity
US immigrants lose bacterial enzymes associated with plant fiber degradation
Bacteroides strains displace Prevotella strains according to time spent in the USA
Loss of diversity increases with obesity and is compounded across generations
Summary
Many US immigrant populations develop metabolic diseases post immigration, but the causes are not well understood. Although the microbiome plays a role in metabolic disease, there have been no studies measuring the effects of US immigration on the gut microbiome. We collected stool, dietary recalls, and anthropometrics from 514 Hmong and Karen individuals living in Thailand and the United States, including first- and second-generation immigrants and 19 Karen individuals sampled before and after immigration, as well as from 36 US-born European American individuals. Using 16S and deep shotgun metagenomic DNA sequencing, we found that migration from a non-Western country to the United States is associated with immediate loss of gut microbiome diversity and function in which US-associated strains and functions displace native strains and functions. These effects increase with duration of US residence and are compounded by obesity and across generations.
...
Pajau Vangay, Abigail J. Johnson, Tonya L. Ward, Gabriel A. Al-Ghalith, Robin R. Shields-Cutler, Benjamin M. Hillmann, Sarah K. Lucas, Lalit K. Beura, Emily A. Thompson, Lisa M. Till, Rodolfo Batres, Bwei Paw, Shannon L. Pergament, Pimpanitta Saenyaku, Mary Xiong, Austin D. Kim, Grant Kim, David Masopust, Eric C. Martens, Chaisiri Angkurawaranon, Rose McGready, Purna C. Kashyap, Kathleen A. Culhane-Pera, Dan Knights
Published: November 1, 2018 DOI:https://doi.org/10.1016/j.cell.2018.10.029
Highlights
US immigration is associated with loss of gut microbiome diversity
US immigrants lose bacterial enzymes associated with plant fiber degradation
Bacteroides strains displace Prevotella strains according to time spent in the USA
Loss of diversity increases with obesity and is compounded across generations
Summary
Many US immigrant populations develop metabolic diseases post immigration, but the causes are not well understood. Although the microbiome plays a role in metabolic disease, there have been no studies measuring the effects of US immigration on the gut microbiome. We collected stool, dietary recalls, and anthropometrics from 514 Hmong and Karen individuals living in Thailand and the United States, including first- and second-generation immigrants and 19 Karen individuals sampled before and after immigration, as well as from 36 US-born European American individuals. Using 16S and deep shotgun metagenomic DNA sequencing, we found that migration from a non-Western country to the United States is associated with immediate loss of gut microbiome diversity and function in which US-associated strains and functions displace native strains and functions. These effects increase with duration of US residence and are compounded by obesity and across generations.
...
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US Immigration Westernizes the Human Gut Microbiome (Original Post)
sl8
Nov 2018
OP
littlemissmartypants
(22,805 posts)1. Fascinating, sl8.
Thanks for sharing. I've been reading a lot of interesting things about the biosphere lately. I enjoyed this.
Thanks again.
♡ lmsp
Duppers
(28,127 posts)2. Might designer probiotics help with this?
Long-term, of course.