Science

muriel_volestrangler

(101,384 posts) Wed Jan 3, 2024, 01:51 PM Jan 2024

Scientists hail new antibiotic that can kill drug-resistant bacteria

Scientists have discovered an entirely new class of antibiotic that appears to kill one of three bacteria considered to pose the greatest threat to human health because of their extensive drug-resistance.

Zosurabalpin defeated highly drug-resistant strains of Carbapenem-resistant Acinetobacter baumannii (Crab) in mouse models of pneumonia and sepsis, and was being tested in human trials.

Crab is classified as a priority 1 critical pathogen by the World Health Organization, alongside two other drug-resistant forms of bacteria – Pseudomonas aeruginosa and Enterobacteriaceae.
...
No new antibiotic for Gram-negative bacteria have been approved in more than 50 years.

https://www.theguardian.com/science/2024/jan/03/scientists-new-class-antibiotic-kill-drug-resistant-bacteria

While remembering that "the progression of new drugs from animal studies into humans could be extremely difficult" as the article says, still looks like excellent news.

13 replies

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Scientists hail new antibiotic that can kill drug-resistant bacteria (Original Post) muriel_volestrangler Jan 2024 OP

If this proves effective for humans... pandr32 Jan 2024 #1

...for a few years. ret5hd Jan 2024 #2

Yep - thanks for the reality check rurallib Jan 2024 #3

They can't do that if they're eradicated ck4829 Jan 2024 #6

They won't be eradicated paleotn Jan 2024 #9

'Discovered,' or 'developed?' elleng Jan 2024 #4

A little of each? muriel_volestrangler Jan 2024 #7

Science! Mr. Evil Jan 2024 #5

Well, there was methocillin for pennicillin resistance... NNadir Jan 2024 #8

Vancomycin I_UndergroundPanther Jan 2024 #13

I've read that scientists have used AI to help them develop these drugs. ancianita Jan 2024 #10

I wonder if anyone will able to afford any new drugs. Cost is so out of control. mucifer Jan 2024 #11

I had a bout with a bad infection I_UndergroundPanther Jan 2024 #12

pandr32

(11,619 posts)

1. If this proves effective for humans...

Reply to muriel_volestrangler (Original post)

Wed Jan 3, 2024, 01:58 PM

Jan 2024

game changer!

ret5hd

(20,525 posts)

2. ...for a few years.

Reply to pandr32 (Reply #1)

Wed Jan 3, 2024, 02:22 PM

Jan 2024

rurallib

(62,455 posts)

3. Yep - thanks for the reality check

Reply to ret5hd (Reply #2)

Wed Jan 3, 2024, 02:47 PM

Jan 2024

ck4829

(35,093 posts)

6. They can't do that if they're eradicated

Reply to ret5hd (Reply #2)

Wed Jan 3, 2024, 03:18 PM

Jan 2024

paleotn

(17,989 posts)

9. They won't be eradicated

Reply to ck4829 (Reply #6)

Wed Jan 3, 2024, 03:47 PM

Jan 2024

That’s not going to happen. We live in a microbe dominated world and some of those microbes aren’t very nice. We only think we’re on top of the food chain.

elleng

(131,163 posts)

4. 'Discovered,' or 'developed?'

Reply to muriel_volestrangler (Original post)

Wed Jan 3, 2024, 02:57 PM

Jan 2024

muriel_volestrangler

(101,384 posts)

7. A little of each?

Reply to elleng (Reply #4)

Wed Jan 3, 2024, 03:36 PM

Jan 2024

To see if they could develop a new drug that could overcome CRAB’s resistance, the researchers turned to a class of molecules called tethered macrocyclic peptides. Earlier studies on the compounds had revealed little antibiotic activity, but a screening of more than 45,000 of them showed that one was able to selectively kill A. baumannii. After a little tweaking, they tested the resulting drug, zosurabalpin, in mouse models of CRAB infection in pneumonia, a thigh wound and sepsis. The drug was effective in reducing the bacteria in all three groups and improved the rate of survival in the sepsis models. It was also effective in killing A. baumannii in more than 100 clinical samples.

https://www.fiercebiotech.com/research/roche-designs-new-antibiotic-fight-deadly-baumannii-infections

Mr. Evil

(2,856 posts)

5. Science!

Reply to muriel_volestrangler (Original post)

Wed Jan 3, 2024, 03:05 PM

Jan 2024

NNadir

(33,563 posts)

8. Well, there was methocillin for pennicillin resistance...

Reply to muriel_volestrangler (Original post)

Wed Jan 3, 2024, 03:40 PM

Jan 2024

...and then this led to MREs, methocillin resistant enterococcus, and then Vancomycin, and then VREs.

It's a battle with evolution and it will never end.

There was a golden age of antibiotics, but it may be coming to an end, with or without abuse.

I_UndergroundPanther

(12,480 posts)

13. Vancomycin

Reply to NNadir (Reply #8)

Thu Jan 4, 2024, 01:29 AM

Jan 2024

Was one of the antibiotics they used to try to kill the cellulitis on my face. They used antibiotics I didnt know existed.

ancianita

(36,137 posts)

10. I've read that scientists have used AI to help them develop these drugs.

Reply to muriel_volestrangler (Original post)

Wed Jan 3, 2024, 04:03 PM

Jan 2024

https://archive.ph/HdYal

mucifer

(23,572 posts)

11. I wonder if anyone will able to afford any new drugs. Cost is so out of control.

Reply to muriel_volestrangler (Original post)

Wed Jan 3, 2024, 10:08 PM

Jan 2024

I_UndergroundPanther

(12,480 posts)

12. I had a bout with a bad infection

Reply to muriel_volestrangler (Original post)

Thu Jan 4, 2024, 01:25 AM

Jan 2024

I had cellulitis on my face. I was told It was gram negative bacteria. I was in the hospital for days as they tried to find an antibiotic that would kill it. My gut flora is a desert now. Taking prescription florestor and diflucan.My face looked awful. But I am ok now.
A drug like the new one would have not had them searching for something to kill it for so long.

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